Abstract: Provided herein are methods of administering gapmer oligomeric compounds with GalNAc conjugate groups to a human.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: Methods for making thin-films on semiconductor substrates, which may be patterned using EUV, include: depositing the organometallic polymer-like material onto the surface of the semiconductor substrate, exposing the surface to EUV to form a pattern, and developing the pattern for later transfer to underlying layers. The depositing operations may be performed by chemical vapor deposition (CVD), atomic layer deposition (ALD), and ALD with a CVD component, such as a discontinuous, ALD-like process in which metal precursors and counter-reactants are separated in either time or space.

Abstract: A method for identifying malicious software includes receiving and executing a software application, identifying a plurality of uniform resource identifiers the software application interacts with during execution of the software application, and generating a vector representation for the software application using a feed-forward neural network configured to receive the plurality of uniform resource identifiers as feature inputs. The method also includes determining similarity scores for a pool of training applications, each similarity score associated with a corresponding training application and indicating a level of similarity between the vector representation for the software application and a respective vector representation for the corresponding training application.

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

Abstract: Media hub systems and methods for providing content for display on a device provided. The media system may include a hub and a mount configured to secure the hub to a plurality of structures. The hub may include a camera and be configured to provide content for display on a device. The mount may be configured to couple to the hub via a magnetic connection. The magnetic connection may be configured to allow the hub to tilt relative to the mount to adjust a field-of-view of the camera.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: In an embodiment a switching device includes at least one fixed contact, a contact bridge and a upper yoke element in a switching chamber, wherein the upper yoke element is attached to the switching chamber, wherein the upper yoke element has a recess on a lower side facing the contact bridge, and wherein the contact bridge projects at least partially into the recess in an switched-on state of the switching device.

Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.

Abstract: The invention relates to nanohybrids that are gold nanorod J-aggregates having a broadened surface plasmonic resonance band, processes of making such gold nanorod J-aggregates and products comprising such gold nanorod J-aggregates. Such gold nanorod J-aggregates exhibit broad localized surface plasmonic reasonable range from 800 nm to 2000 nm.

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc?Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, sending, to a client device associated with the user, a first data string associated with a first validity period; receiving, from the client device after expiry of the first authenticated user session, a data access request to access protected data, the data access request including the first data string; validating the first data string based on checking the first validity period; and in response to determining that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the requested protected data.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.

Abstract: Compositions and methods for displaying antibodies in the periplasmic space of yeast cells are disclosed. In particular, antibodies are linked to a cell membrane-spanning transmembrane domain, a cell-membrane associated protein domain that is on the external face of the yeast cell membrane, a protein that binds to the inner face of the yeast cell wall, or a periplasmic protein in order to display the antibodies in the yeast periplasmic space. In addition, a target protein of interest can be coexpressed in yeast such that it is localized to the plasma membrane or periplasmic space and accessible to binding by displayed antibodies. The disclosure further relates to high-throughput screening of antibody libraries using yeast cell periplasmic display.

Abstract: Devices and methods for providing alert notifications. The device includes an input module, a display, and memory having instructions. The device receives, via the input module, a first signal representing a command to set an alert condition associated with an identifier and, in response, generates the alert condition. The device transmits a second signal representing the alert condition to a monitoring system for setting up a targeted notification. The device receives a third signal representing an asserted alert indicating that the alert condition is satisfied and displays on the display, based on the third signal representing the asserted alert, an alert notification including the identifier and a first selectable option associated with a first application interface. In response to receiving, via the input module, a fourth signal representing selection of the first selectable option, the device displays the first application interface and auto-populates a first field based on the identifier.

Abstract: A computer-implemented method is disclosed. The method includes: authenticating a user for login to a service for a first authenticated user session; in response to authenticating the user, generating a first data string associated with a first validity period; sending, to a client device associated with the user, the first data string; receiving, from the client device, a data access request to access a first data set at a remote data source, the data access request including the first data string; determining that the first authenticated user session has been terminated at a time of receiving the data access request; validating the first data string based on checking the first validity period; and in response to determining that the first authenticated user session has been terminated and that the first data string is valid, transmitting, to the client device, a data access response including at least a subset of the first data set.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: A method for real-time processing of data retrieval requests is disclosed. The method includes: receiving, from a client device, a first login request to log in to a service; authenticating the user for login to the service; in response to authenticating the user, generating a first data string representing at least a unique device identifier for the client device and a validity period; storing the device identifier; sending, to the client device, the first data string; receiving, from the client device, a data retrieval request to retrieve a data set from a remote server, the data retrieval request including the first data string; determining whether the first data string is valid based on checking the validity period; in response to determining that the first data string is valid: obtaining the data set from the remote server; and sending, to the client device, first data based on the obtained data set.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.