Patents by Inventor Rino Rappuoli

Rino Rappuoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIV TAT-CD4 HYBRID MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20120183557
    Abstract: Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
    Type: Application
    Filed: March 22, 2012
    Publication date: July 19, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS. INC.
    Inventors: Susan BARNETT, Rino RAPPUOLI, Victoria A. SHARMA, Indresh K. SRIVASTAVA, Jan ZUR MEGEDE
  • Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing CG motifs
    Patent number: 8221761
    Abstract: Immunogenic compositions (e.g. vaccines) comprising: (a) an immunostimulating amount of a Neisseria antigen (preferably N. meningitidis serogroup B); and (b) an immunostimulating amount of an adjuvant composition comprising an oligonucleotide comprising at least one CG motif. Component (b) may further comprise a second adjuvant. Component (a) may be selected from a variety of antigens. Adjuvant compositions comprising an oligonucleotide having at least one CG motif, and complete Freund's adjuvant (CFA) are also provided.
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: July 17, 2012
    Assignee: Novartis AG
    Inventors: Guido Grandi, Rino Rappuoli, Marzia M. Giuliani, Mariagrazia Pizza
  • FUSION PROTEINS COMPRISING CD4 MINIMAL MODULES AND METHODS OF USE THEREOF
    Publication number: 20120177657
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 12, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
    Inventors: Vega MASIGNANI, Maria SCARSELLI, Barbara CAPECCHI, Victoria SHARMA, Susan W. BARNETT, Indresh K. SRIVASTAVA, Rino RAPPUOLI
  • NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS
    Publication number: 20120164166
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 28, 2012
    Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.
    Inventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
  • Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes
    Patent number: 8206720
    Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: June 26, 2012
    Assignee: Novartis Vaccines & Diagnostics, Inc
    Inventors: Vega Masignani, Maria Scarselli, Barbara Capecchi, Victoria Sharma, Susan W. Barnett, Indresh K. Srivastava, Rino Rappuoli
  • NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS
    Publication number: 20120156236
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 21, 2012
    Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.
    Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
  • NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS
    Publication number: 20120148616
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Application
    Filed: January 26, 2012
    Publication date: June 14, 2012
    Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.
    Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
  • NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS
    Publication number: 20120135024
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Application
    Filed: March 23, 2011
    Publication date: May 31, 2012
    Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.
    Inventors: Claire FRASER, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
  • COMBINATION NEISSERIAL COMPOSITIONS
    Publication number: 20120135026
    Abstract: Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 31, 2012
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Marzia Monica Giuliani, Mariagrazia Pizza, Rino Rappuoli
  • Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
    Patent number: 8168194
    Abstract: Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: May 1, 2012
    Assignee: Novartis Vaccines & Diagnostics, Inc.
    Inventors: Susan Barnett, Rino Rappuoli, Victoria A. Sharma, Indresh K. Srivastava, Jan Zur Megede
  • HAEMOPHILUS INFLUENZAE TYPE B
    Publication number: 20120093868
    Abstract: Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
    Type: Application
    Filed: December 21, 2011
    Publication date: April 19, 2012
    Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Vega MASIGNANI, Rino Rappuoli, Herve Tettelin
  • POLYPEPTIDE CARRIER PROTEIN
    Publication number: 20120070456
    Abstract: The invention relates to polypeptide carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
    Type: Application
    Filed: December 1, 2010
    Publication date: March 22, 2012
    Inventors: Rino Rappuoli, Guido Grandi
  • POLYPEPTIDES FROM NEISSERIA MENINGITIDIS
    Publication number: 20120027801
    Abstract: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 2, 2012
    Applicants: J. CRAIG VENTER INSTITUTE, INC., NOVARTIS AG
    Inventors: Rino Rappuoli, Claire Fraser, Mariagrazia Pizza, Maria Scarselli, Davide Serruto, Hervé Tettelin
  • FACTOR H BINDING PROTEIN IMMUNOGENS
    Publication number: 20110300171
    Abstract: The invention relates to immunization against pathogenic bacterial strains which express or can express multiple factor H binding proteins. Certain aspects of the invention include vaccine compositions comprising at least two factor H binding proteins derived from a pathogenic bacterial strain which expresses multiple facto H binding proteins.
    Type: Application
    Filed: September 14, 2009
    Publication date: December 8, 2011
    Applicants: HUMANITAS MIRASOLE S.P.A., NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.
    Inventors: Silvana Savino, John Donnelly, Rino Rappuoli, Mariagrazia Pizza, Barbara Bottazzi
  • Polypeptides from
    Patent number: 8039007
    Abstract: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: October 18, 2011
    Assignees: J. Craig Venter Institute, Inc., Novartis AG
    Inventors: Rino Rappuoli, Claire Fraser, Mariagrazia Pizza, Maria Scarselli, Davide Serruto, Hervé Tettelin
  • VACCINE ADJUVANT COMBINATIONS
    Publication number: 20110236489
    Abstract: An immunological adjuvant comprises an oil-in-water emulsion, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be combined with immunogens for preparing vaccines.
    Type: Application
    Filed: September 18, 2009
    Publication date: September 29, 2011
    Applicant: NOVARTIS AG
    Inventors: Michele Pallaoro, Derek O'Hagan, Rino Rappuoli
  • VACCINATION WITH MULTIPLE CLADES OF H5 INFLUENZA A VIRUS
    Publication number: 20110189230
    Abstract: H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used in influenza immunization. Thus there is a prime-boost immunization schedule where a subject receives a priming dose of a first clade of H5 influenza A virus and a boosting dose of a second clade of H5 influenza A virus. There is also an immunogenic composition comprising hemagglutinin antigens from more than one clade of H5 influenza A virus.
    Type: Application
    Filed: November 25, 2008
    Publication date: August 4, 2011
    Applicant: Novartis Vaccines and Diagnostics SRL
    Inventors: Audino Podda, Rino Rappuoli
  • antigens and compositions
    Patent number: 7988979
    Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: August 2, 2011
    Assignees: J. Craig Venter Institute, Inc., Novartis AG
    Inventors: Claire M. Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Maria Rosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulo Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, Craig Venter
  • ADJUVANTED INFLUENZA VACCINES INCLUDING CYTOKINE-INDUCING AGENTS
    Publication number: 20110180430
    Abstract: While oil-in-water emulsions are excellent adjuvants for influenza vaccines, their efficacy can be improved by additionally including other immunostimulating agent(s) to improve cytokine responses, such as ?-interferon response. Thus, a vaccine comprises (i) an influenza virus antigen; (ii) an oil-in-water emulsion adjuvant; and (iii) a cytokine-inducing agent.
    Type: Application
    Filed: November 6, 2006
    Publication date: July 28, 2011
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Rino Rappuoli, Derek O'Hagan, Giuseppe Del Giudice
  • CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870
    Publication number: 20110166323
    Abstract: NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
    Type: Application
    Filed: November 27, 2006
    Publication date: July 7, 2011
    Applicant: NOVARTIS VACCINES AND DIAGNOSTICS SRL
    Inventors: Vega Masignani, Maria Scarselli, Rino Rappuoli, Mariagrazia Pizza, Marzia Monica Giuliani