Patents by Inventor Riqiang Yan

Riqiang Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combining BACE1 Inhibitors With mGluR Agonists For Alzheimer's Disease Therapy
    Publication number: 20210161910
    Abstract: Disclosed pharmaceutical compositions including a Beta site APP Cleaving Enzyme (BACE1) inhibitor and an metabotropic glutamate receptor (mGluR) agonist, and methods for use of such compositions to treat Alzheimer's disease (AD), Down's syndrome, Parkinson's disease, vascular dementia, Dementia with Lewy Bodies, dementia, and/or frontal temporal dementia.
    Type: Application
    Filed: December 1, 2020
    Publication date: June 3, 2021
    Inventors: Riqiang Yan, Brati Das
  • Alzheimer's Disease Secretase, APP Substrates Therefor, and Uses Therefor
    Publication number: 20110294149
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: May 20, 2011
    Publication date: December 1, 2011
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Substrates and assays for ?-secretase
    Patent number: 7888291
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: February 15, 2011
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Alzheimer's disease secretase
    Patent number: 7812123
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: October 12, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Mark E. Gurney, Michael Jerome Bienkowski, Robert Leroy Heinrikson, Luis A. Parodi, Riqiang Yan
  • Substrates and assays for ?-secretase
    Patent number: 7803739
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: September 28, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Alzheimer's Disease Secretase, APP Substrates Therefor and Uses Therefor
    Publication number: 20090075316
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: July 18, 2008
    Publication date: March 19, 2009
    Applicant: PHARMACIA & UPJOHN CO.
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Substrates and assays for beta-secretase activity
    Publication number: 20080299596
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 1, 2007
    Publication date: December 4, 2008
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Alzheimer's Disease Secretase, APP Substrates Therefor and Uses Therefor
    Publication number: 20080171349
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: July 11, 2007
    Publication date: July 17, 2008
    Applicant: PHARMACIA & UPJOHN CO.
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 7378511
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: May 27, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 7375187
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: May 20, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowaki, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 7368536
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: May 6, 2008
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Substrates and Assays for Beta Secretase Activity
    Publication number: 20080090260
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: April 17, 2008
    Inventors: Riqiang Yan, Alfredo Tomasselli, Mark Gurney, Thomas Emmons, Michael Bienkowski, Robert Heinrikson
  • Substrates and assays for ?-secretase activity
    Patent number: 7205120
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: April 17, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Alzheimer's disease secretase, APP substrates therefor, and uses thereof
    Patent number: 7041473
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: May 9, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Alzheimer's disease secretase, APP substrates therefor, and uses therefor
    Patent number: 6913918
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: July 5, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Substrates and assays for beta-secretase
    Publication number: 20050096457
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Application
    Filed: March 16, 2004
    Publication date: May 5, 2005
    Applicant: Pharmacia & Upjohn Company, a Delaware corporation
    Inventors: Riqiang Yan, Alfredo Tomasselli, Mark Gurney, Thomas Emmons, Michael Bienkowski, Robert Heinrikson
  • Alzheimer's disease secretase, app substrates therefor, and uses therefor
    Publication number: 20050080232
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: May 9, 2001
    Publication date: April 14, 2005
    Inventors: Mark Gurney, Michael Bienkowski, Robert Heinrikson, Luis Parodi, Riqiang Yan
  • Alzheimer's disease secretase, APP substrates therefor, and uses thereof
    Patent number: 6867018
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: March 15, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Alzheimer's disease secretase
    Publication number: 20050026256
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the ? secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
    Type: Application
    Filed: September 14, 2004
    Publication date: February 3, 2005
    Inventors: Mark Gurney, Michael Bienkowski, Robert Heinrikson, Luis Parodi, Riqiang Yan
  • Alzheimer's disease secretase
    Patent number: 6835565
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: December 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael Jerome Bienkowski, Robert Leroy Heinrikson, Luis A. Parodi, Riqiang Yan