Abstract: An apparatus for combining a first liquid component 90 stored in a container 125 and a second component stored in a vial 7 by means of negative pressure is disclosed. A tray 1 has a vial cavity 11 and a container cavity 12. A dual-ended transfer needle 131 is fixedly held at the tray 1 at an intermediate needle holding portion 13 between the vial cavity 11 and the container cavity 12 for establishing a fluid communication between the vial 7 and the container 125 by piercing a rubber stopper of the vial and a bottom of the container, respectively. The vial cavity 11 guides the vial 7 along an axial direction AD from an intermediate position towards the transfer position for fluid communication. And the container cavity 12 guides the container 125 along the axial direction AD from an intermediate position towards the transfer position for fluid communication.

Abstract: A tubular locking body of a tamper evident plastic closure for necked vials for holding a plug in a mouth of a vial includes a retaining member for retaining the plug, a central opening being formed in the retaining member for providing access to the inside of the vial via the plug. The cap includes a disc-shaped cover and a coupling portion, for coupling the cap with the tubular locking body by positive-fit engagement. The coupling portion includes at least one frangible portion each configured such that at least one indicator member remains as a tamper evidence at a rim of the central opening of the tubular locking body after removal of the cap from the distal end of the tubular locking body by irreversibly breaking the annular frangible portion for providing access to the inside of the vial via the plug.

Abstract: In a locking device for locking a plunger rod a plunger rod locking portion is provided for locking a plunger rod of a syringe after use and preventing re-use of the syringe. A chamber is formed inside the plunger rod locking portion for receiving the disc-shaped proximal end of the plunger rod after use of the syringe. The plunger rod locking portion comprises at least one positive locking device configured to positively lock the axial position of the plunger rod by positive-fit engagement with the disc-shaped proximal end of the plunger rod and retain the disc-shaped proximal end of the plunger rod inside the chamber. The locking device provides the functionality of a tamper-evident plunger rod locking device once a dose of medication has been injected by pushing the plunger rod forward, for preventing inadvertent re-use of the syringe.

Abstract: A tray for positioning, in a fixed positional relationship, a medical vial 7 together with a vial adapter 4 is disclosed. A tray member 10 includes a vial accommodation cavity 11 and a vial adapter accommodation cavity 12, each comprises retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b configured to position the vial adapter 4 and the vial 7 spaced apart from each other and in axial alignment in an intermediate position. The retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b are further configured to guide a relative axial movement of the vial 7 and vial adapter 4 from the intermediate position to a transfer position while maintaining the axial alignment of the vial 7 with the vial adapter 4. In the transfer position the vial adapter 4 is locked to the vial 7 and a piercing mandrel 57 pierces a vial stopper 76 for liquid transfer.

Abstract: The invention relates to a tamper evident plastic closure for necked vials, for holding a plug in a mouth of a vial, comprising: a tubular locking body configured to be locked at the neck of the vial, and a cap coupled with the tubular locking body. The tubular locking body comprises a retaining member for retaining the plug, a central opening being formed in the retaining member for providing access to the inside of the vial via the plug. The cap comprises a disc-shaped cover and a coupling portion, for coupling the cap with the tubular locking body by positive-fit engagement. The coupling portion comprises at least one frangible portion each configured such that at least one indicator member remains as a tamper evidence at a rim of the central opening of the tubular locking body after removal of the cap from the distal end of the tubular locking body by irreversibly breaking the annular frangible portion for providing access to the inside of the vial via the plug.

Abstract: In a locking device for locking a plunger rod a plunger rod locking portion is provided for locking a plunger rod of a syringe after use and preventing re-use of the syringe. A chamber is formed inside the plunger rod locking portion for receiving the disc-shaped proximal end of the plunger rod after use of the syringe. The plunger rod locking portion comprises at least one positive locking device configured to positively lock the axial position of the plunger rod by positive-fit engagement with the disc-shaped proximal end of the plunger rod and retain the disc-shaped proximal end of the plunger rod inside the chamber. The locking device provides the functionality of a tamper-evident plunger rod locking device once a dose of medication has been injected by pushing the plunger rod forward, for preventing inadvertent re-use of the syringe.

Abstract: A supporting structure for supporting a plurality of sealed medical cartridges is disclosed, comprising a planar supporting plate having a plurality of receptacles for accommodating the sealed cartridges. Retaining protrusions are formed at the bottom ends of the receptacles protruding inward, which are mated with the shoulder portions of the sealed cartridges in such a manner that the shoulder portions of the sealed cartridges are supported on the retaining protrusions of the receptacles and that the upper ends of the sealed cartridges protrude from the upper ends of the receptacles at an upper side of the planar supporting plate, when the sealed cartridges are accommodated upside-down in the receptacles. The inventive nest will be suitable for any nested liquid filling machine without much changes in filling table and general settings.

Abstract: A supporting structure for supporting a plurality of sealed medical cartridges is disclosed, comprising a planar supporting plate having a plurality of receptacles for accommodating the sealed cartridges. Retaining protrusions are formed at the bottom ends of the receptacles protruding inward, which are mated with the shoulder portions of the sealed cartridges in such a manner that the shoulder portions of the sealed cartridges are supported on the retaining protrusions of the receptacles and that the upper ends of the sealed cartridges protrude from the upper ends of the receptacles at an upper side of the planar supporting plate, when the sealed cartridges are accommodated upside-down in the receptacles. The inventive nest will be suitable for any nested liquid filling machine without much changes in filling table and general settings.