Patents by Inventor Rita Perlingeiro

Rita Perlingeiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced differentiation and maturation of pluripotent stem cell-derived myogenic cells
    Patent number: 11697798
    Abstract: A method to increase the efficiency of myotube generation and maturation from pluripotent stem cells comprising: (a) differentiating pluripotent stem cells to myogenic progenitors; and (b) terminally differentiating said myogenic progenitors from (a) into myotubes in the presence of at least one gamma secretase inhibitor, wherein myotube generation is increased in the presence of at least one gamma secretase inhibitor, as compared to differentiation in the absence of gamma secretase inhibitors.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: July 11, 2023
    Assignee: Regents of the University of Minnesota
    Inventors: Rita Perlingeiro, Sridhar Selvaraj, Ricardo Mondragon Gonzalez
  • ENHANCED DIFFERENTIATION AND MATURATION OF PLURIPOTENT STEM CELL-DERIVED MYOGENIC CELLS
    Publication number: 20210171911
    Abstract: A method to increase the efficiency of myotube generation and maturation from pluripotent stem cells comprising: (a) differentiating pluripotent stem cells to myogenic progenitors; and (b) terminally differentiating said myogenic progenitors from (a) p into myotubes in the presence of at least one gamma secretase inhibitor, wherein myotube generation is increased in the presence of at least one gamma secretase inhibitor, as compared to differentiation in the absence of gamma secretase inhibitors.
    Type: Application
    Filed: December 13, 2018
    Publication date: June 10, 2021
    Inventors: Rita Perlingeiro, Sridhar Selvaraj, Ricardo Mondragon Gonzalez
  • SURFACE MARKERS FOR THE ISOLATION OF MYOGENIC STEM/PROGENITOR CELLS
    Publication number: 20190352611
    Abstract: Provided herein are isolated myogenic progenitor cells, methods to isolate myogenic progenitor cells and method of their use.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 21, 2019
    Inventors: Rita Perlingeiro, Alessandro Magli
  • Gene targeting methods and tools
    Patent number: 9850497
    Abstract: Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to subject (e.g., patient), as well as a set of tools (TALENs and gene targeting vectors) to accomplish such method.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: December 26, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Rita Perlingeiro, Michael Kyba, Fabrizio Rinaldi, Daniel F. Voytas
  • GENE TARGETING METHODS AND TOOLS
    Publication number: 20150125429
    Abstract: Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to subject (e.g., patient), as well as a set of tools (TALENs and gene targeting vectors) to accomplish such method.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 7, 2015
    Inventors: Rita Perlingeiro, Michael Kyba, Fabrizio Rinaldi, Daniel F. Voytas
  • Correction of genetic defects
    Publication number: 20030228293
    Abstract: A method of correcting of treating a genetic disorder by combining therapeutic cloning and gene therapy.
    Type: Application
    Filed: March 7, 2003
    Publication date: December 11, 2003
    Applicants: Whitehead Institute for Biomedical Research, The General Hospital Corporation
    Inventors: William Rideout, Konrad Hochedlinger, Michael Kyba, Rita Perlingeiro, George Q. Daley, Rudolf Jaenisch