Abstract: The present disclosure relates to a subtle cornea deformation identification method and device based on a pixel-level corneal biomechanical parameter, including the following steps: step 1, sampling and analyzing a dynamic video of corneal stress deformation in a historical database, and calculating pixel-level data; and step 2, configuring an ensemble classifier based on a sampling result and detecting a local change in corneal biomechanics, thus identifying a subtle cornea deformation. The present disclosure has high measurement accuracy and is capable of detecting a local subtle biomechanical change.