Abstract: The present invention provides compounds and pharmaceutical compositions including the compounds for the treatment of a skin disease associated with proteolytic activity of one or more KLK proteases, wherein the compounds are according to formula (I): wherein R is as described herein.

Abstract: An implant composed of a plurality of parts placed within a vertebral body such that the vertebral body can be displaced, altering the angle between the superior endplate and the inferior endplate resulting in correction of the vertebral alignment in the coronal plane.

Abstract: An implant composed of a plurality of parts placed within a vertebral body such that the vertebral body can be displaced, altering the angle between the superior endplate and the inferior endplate resulting in correction of the vertebral alignment in the coronal plane.

Abstract: This invention relates to an implant (20) and application thereof to correct coronal alignment in the vertebral column.

Abstract: A flexible circuit includes a plurality of electrical traces and a plurality of probe tips directly formed thereto. The electrical traces are made of a first electrically conductive material and the probe tips are made of a second electrically conductive material that is harder than the first electrically conductive material. The first material is copper or a copper alloy and the second matieral is nickel or a nickel alloy, where the second material may be plated with gold. Portions of the probe tips are exposed to facilitate electrical contact with contact pads of another electrical circuit. The flexible circuit may also include a ground layer to facilitate electrical correction with another electrical circuit at relatively high frequencies.

Abstract: An improved hybrid luminescent device and method for converting penetrating radiation energy into visible light for imaging applications. The hybrid luminescent device includes a phosphor screen disposed on an entrance face fiber optics scintillator which, in turn, may be removably coupled to a camera or like recording media. The hybrid luminescent device of the present invention is capable of providing enhanced radiation absorption efficiency, higher spatial resolution and enhanced brightness or luminescence output over that which is achievable by the phosphor screen and/or fiber optics scintillator when used separately as an intensifying screen for imaging of ionizing and/or penetrating radiation.

Abstract: A hybrid luminescent device for converting ionizing and penetrating radiation energy such as x-rays, gamma rays, neutrons, ions, electrons, and the like into visible light for imaging applications. The hybrid luminescent device includes a phosphor screen disposed on an entrance face fiber optics scintillator which, in turn, may be removably coupled to a camera or like recording media. The hybrid luminescent device of the present invention is capable of providing enhanced radiation absorption efficiency, higher spatial resolution and enhanced brightness or luminescence output over that which is achievable by the phosphor screen and/or fiber optics scintillator when used separately as an intensifying screen for imaging of ionizing and/or penetrating radiation.