Abstract: 2-Aminopyridine compounds of Formula I are provided, and various substituents including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for modulating USP7, and for treating cancer and immune disorders such as inflammation mediated by USP7. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A system for determining cardiac targets is provided. The system may include at least one processing device configured to carry out instructions to receive cardiac imaging data, segment the cardiac imaging data to identify at least two types of cardiac tissue, generate a cardiac model based on the identified tissue, simulate cardiac activity based on the generated cardiac model, and identify at least one cardiac target based on the simulation. A cardiac therapy system may be utilized to provide feedback to a user in order to guide a cardiac treatment device to a cardiac target.

Abstract: An optical reader for decoding an encoded symbol character of a symbology includes a scan data signal processor having as an input a scan data signal encoding information representative of the encoded symbol character. The scan data signal processor includes a first time delay stage adapted to provide a primary phase waveform from the scan data signal, a second time delay stage adapted to provide an early phase waveform from the scan data signal, and a third time delay stage adapted to provide a delayed phase waveform from the scan data signal. The early phase waveform has a propagation delay less than the primary phase waveform, and the delayed phase waveform has a propagation delay greater than the primary phase waveform. The scan data signal processor further includes a peak window detection stage for generating a peak window timeframe when an amplitude of the primary phase waveform is greater than, less than, or equal to both an amplitude of the early phase waveform and the delayed phase waveform.

Abstract: A home appliance having a treating chamber for receiving an article for treatment according to an automatic cycle of operation, a treating chamber having an open face, a door for selectively closing the open face of the treating chamber, a sensor configured to sense a user at a predetermined location with respect to the home appliance and provide a signal based thereon, an actuator operably coupled with the door and a method for operating a home appliance.

Abstract: A laundry treating appliance and a method operating a laundry treating appliance having at least one automatic cycle of operation, a plurality of components selectively operable by a controller to implement the at least one cycle of operation on a load of laundry received within a treating chamber of the appliance with the controller having a user interface for receiving input from a user and a door for closing an open face of the treating chamber, the method comprising determining a movement of the door in a closing direction and actuating the user interface when it is determined the door is moved in the closing direction.

Abstract: Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.

Abstract: A speaker is provided with multiple sound ports and a port plug. The sound port plug is used to close one of the sound ports while leaving the other sound port open to transmit sound. The speaker may have a first sound port located on the front of the speaker and a second sound port located on the rear of the speaker. In using the speaker, a person selects between the front port and the rear port and closes the undesired sound port.

Abstract: Method of and system for reading code symbols a dual-laser scanning bar code symbol reading system having the capacity to automatically select in a user-transparent manner, and activate either a near-field source of laser illumination, or a far-field source of laser illumination, using an automatic object presence detection subsystem in the near-field portion of the laser scanning field.

Abstract: Method of and system for reading code symbols a dual-laser scanning bar code symbol reading system having the capacity to automatically select in a user-transparent manner, and activate either a near-field source of laser illumination, or a far-field source of laser illumination, using an automatic object presence detection subsystem in the near-field portion of the laser scanning field.

Abstract: An optical reader for decoding an encoded symbol character of a symbology includes a scan data signal processor having as an input a scan data signal encoding information representative of the encoded symbol character. The scan data signal processor includes a first time delay stage adapted to provide a primary phase waveform from the scan data signal, a second time delay stage adapted to provide an early phase waveform from the scan data signal, and a third time delay stage adapted to provide a delayed phase waveform from the scan data signal. The early phase waveform has a propagation delay less than the primary phase waveform, and the delayed phase waveform has a propagation delay greater than the primary phase waveform. The scan data signal processor further includes a peak window detection stage for generating a peak window timeframe when an amplitude of the primary phase waveform is greater than, less than, or equal to both an amplitude of the early phase waveform and the delayed phase waveform.

Abstract: Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.

Abstract: A hand-supportable planar laser illumination and imaging (PLIIM) based code symbol reader includes: a hand-supportable housing having light transmission aperture; a linear image formation and detection module having a linear image detection array; and a planar laser illumination beam (PLIB) producing device having at least one visible laser diode (VLD) for producing a planar light illumination beam (PLIB). The code symbol reader further includes image grabber for grabbing digital linear images formed and detected by the image formation and detection module, an image data buffer for buffering the digital linear images grabbed by the image grabber and constructing a two-dimensional image from a series of buffered linear digital images, and an image processing computer for processing the buffered two-dimensional digital image so as to read code symbols graphically represented in the two-dimensional digital linear image.

Abstract: Human GALK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALK1 are provided.

Abstract: Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.

Abstract: A wireless code symbol reading system including a wireless hand-supportable code symbol reader in two-way RF communication with a base station operably connected to a host system, by way of an RF-based wireless data communication link having a predetermined RF communication range over which two-way communication of data packets can occur. The wireless hand-supportable code symbol reader is programmed to automatically detect when it is located inside and outside of the predetermined RF communication range. When the wireless reader is inside the RF communication range, then symbol character data is automatically transmitted to the base station, and when the wireless reader is located outside of the RF communication range, then symbol character data is automatically collected and stored in a data packet buffer, until the wireless reader has re-entered its RF communication range.

Abstract: A planar laser illumination and imaging (PLIIM) based engine including; an engine housing having light transmission aperture; an image formation and detection module and having an image detection array and image formation optics with a field of view (FOV) extending from the image detection array, through the light transmission aperture and onto an object moving relative to the engine housing during object illumination and imaging operations; a planar laser illumination beam (PLIB) producing device, and having at least one visible laser illumination source arranged in relation to the image formation and detection module, for producing a planar light illumination beam (PLIB), and projecting the planar light illumination beam through light transmission aperture and oriented such that the plane of the PLIB is coplanar with the field of view of the image formation and detection module so that the object can be simultaneously illuminated by the planar light illumination beam and imaged within the field of view and

Abstract: A device reduces false positive memory error detections by using a masking unit and sensitivity mask data to exclude unused portions of the memory from the error detection computations. A device includes an error detection unit to read data from the memory and verify data integrity. The sensitivity mask data indicates unused portions of the memory. Unused portions of the memory may correspond with configuration data for unused portions of a programmable device. Each bit of the sensitivity mask data may indicate the usage of one or more bits of the data from the memory. In response to the mask data, the masking unit sets data from the unused portions of the memory to values that do not change the result of the error detection computations. This prevents any errors in data from the unused portions of the memory from raising an error signal.

Abstract: A tunnel-type digital imaging system for use within retail shopping environments such as supermarkets. The system includes a tunnel configuration arranged about a conveyor structure for transporting objects therethrough, and an image capturing and processing subsystem embodied within the tunnel configuration, for generating a 3D digital imaging volume above the conveyor structure and within the tunnel configuration, for capturing digital 1D images of objects transported through the 3D digital imaging volume. The image capturing and processing subsystem includes a plurality of illumination and imaging stations. Each station includes a 2D imaging array having optics providing a 3D field of view (FOV) on the 2D imaging array that is projected and extends into the 3D digital imaging volume, and one or more light emitting devices configured together to produce an illumination beam that extends into the 3D FOV of the 2D imaging array.

Abstract: A tunnel-type digital imaging system for use within retail shopping environments such as supermarkets. The system includes a tunnel configuration arranged about a conveyor structure for transporting objects therethrough, and an image capturing and processing subsystem embodied within the tunnel configuration, for generating a 3D digital imaging volume above the conveyor structure and within the tunnel configuration, for capturing digital 1D images of objects transported through the 3D imaging volume. The image capturing and processing subsystem includes a plurality of coplanar illumination and imaging stations.

Abstract: A hand-supportable planar laser illumination and imaging (PLIIM) based device having hand-supportable housing with a light transmission aperture. A linear image formation and detection (IFD) module is mounted within the housing, and has a linear array of image detection elements and also image formation optics with a field of view (FOV). When an object is presented within the FOV, the FOV focuses a linear image of the object onto the linear array. At least one planar laser illumination module (PLIM) is mounted on the support platform, with the linear IFD module, and produces a planar laser illumination beam (PLIB) spatially aligned with respect to the FOV and arranged in a coplanar relationship with at least a portion of the FOV. A laser beam despeckling mechanism is integrated in the device, for reducing speckle-pattern noise observed the linear digital images formed and detected at the linear array of image detection elements.