Abstract: The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.

Abstract: A system includes a controller, a heating, ventilation, and air conditioning (HVAC) unit, first and second dampers, and first and second pressure sensors. The first damper is positioned at a first air duct that supplies air from an exterior of a premises. The second damper is positioned at a second air duct that supplies air from an interior of the premises. The first pressure sensor is configured to detect an air pressure exterior to the premises. The second pressure sensor is configured to detect an air pressure within the premises. The controller is configured to receive the detected exterior air pressure and the detected interior air pressure, and the controller is configured to change the air pressure within the premises by adjusting at least one of the first damper and the second damper based on the detected exterior and interior air pressures.

Abstract: A prepaid spending card for the storage of funds, the prepaid spending card comprising a single primary account number. The prepaid spending card further comprises a first purse identified by a first pseudo DDA, the first purse authorized to received funds from any available funding source, and a second purse identified by a second pseudo DDA, the second purse authorized to send and receive funds only from restricted sources. The first pseudo DDA is used to route incoming funds to the first purse and the second pseudo DDA is used to route incoming funds to the second purse. Moreover, the first purse receives funds from any available funding source and the second purse receives from restricted funding sources.

Abstract: A method for managing account savings via authorization holds includes: storing an account profile related to a transaction account including an account identifier and primary account number; receiving a savings request including the account identifier and savings data; identifying a starting amount, goal amount, and period of time based on the savings data; generating a first transaction message including the primary account number starting amount; transmitting the first transaction message to a financial institution associated with the related transaction account; generating a second transaction message including the primary account number and goal amount; and transmitting the second transaction message to the financial institution associated with the related transaction account after at least the period of time following transmission of the first transaction message.

Abstract: An angle of repose valve for controlling the flow of granules and a method of repairing a leak in an angle of repose valve are disclosed herein. The angle of repose valve has a housing with an interior cavity, an inlet, and an outlet. A gas is used to convey granules through the valve and the housing has a thickness such that the gas can have a pressure of at least 70 psi. A saddle is disposed in the interior cavity of the housing and is coupled to a rotatable shaft that passes through an opening in the housing. A chevron seal is disposed between the shaft and a sealing member. A compression member is threadably engaged with the sealing member and is operable to exert force on the chevron seal to expand the chevron seal against the shaft and/or the housing to prevent and/or repair leaks of gas therethrough.

Abstract: A method is provided for forming an apex filler including extruding a substantially linear elastomeric strip having a base and a pair of sidewalls converging from the base to an apex. The sidewalls of the elastomeric strip are then engaged with a nip presented by a pair of opposed frusto-conical rollers and a base support. The rollers are rotated to work the elastomeric strip whereby the base of the strip is rotated at a first linear speed, the apex is rotated at a second, greater speed and the sidewalls are rotated at linear speeds substantially proportional to the distance from the base to the apex, thereby forming an apex filler.

Abstract: The present invention provides a method and apparatus for forming an apex filler (13). The invention also provides a method and apparatus that is uniquely adapted for applying an apex filler (13) onto a bead ring sub-assembly (14) without the introduction of stresses at the outer edge (50) of the apex filler (13). The apex filler forming apparatus (10) works in conjunction with an extruder (43) which presents a linear strip (42) of elastomeric material having a pre-determined cross-section. A pair of opposed, forming rollers (33) present a nip (35) therebetween. Means (36) are provided to rotate the rollers (33). Rotation of the forming rollers (33) causes the nip (35) frictionally to engage the elastomeric strip (42). The interaction between the elastomeric strip (42) and the nip (35) effects rotary motion of the elastomeric strip (42) and increases the circumferential length of the elastomeric strip (42) proportionally to the radial distance outwardly from the base (49) thereof.

Abstract: The present invention provides a method and apparatus for forming an apex filler (13). The invention also provides a method and apparatus that is uniquely adapted for applying an apex filler (13) onto a bead ring sub-assembly (14) without the introduction of stresses at the outer edge (50) of the apex filler (13). The apex filler forming apparatus (10) works in conjunction with an extruder (43) which presents a linear strip (42) of elastomeric material having a pre-determined cross-section. A pair of opposed, forming rollers (33) present a nip (35) therebetween. Means (36) are provided to rotate the rollers (33). Rotation of the forming rollers (33) causes the nip (35) frictionally to engage the elastomeric strip (42). The interaction between the elastomeric strip (42) and the nip (35) effects rotary motion of the elastomeric strip (42) and increases the circumferential length of the elastomeric strip (42) proportionally to the radial distance outwardly from the base (49) thereof.

Abstract: A method and apparatus for centering an annular tread on a pneumatic tire-casing is described. The method, preferably put into use with the apparatus, comprises mounting a casing on a wheel, locating the equatorial plane of the casing or wheel, mounting the annular tread on an axially-moveable tread expander assembly, and positioning the tread on the tread expander assembly such that its circumferential center line is located a fixed distance from and parallel to the equatorial plane of the casing or wheel. The distance between the annular tread and the casing or wheel is reduced by an amount equal to the fixed distance so that the annular tread encircles the casing and the circumferential centerline of the tread becomes coincident with the equatorial plane of the casing or wheel.

Abstract: A method of clamping an annular tread to a pneumatic tire casing comprises mounting the casing on a wheel, mounting the annular tread on a tread expander assembly. The assembly expands radially and stretches the tread to a size allowing the tread to circumferentially surround the casing. The stretched annular tread then is moved axially toward the casing to a position where it circumferentially surrounds and is centered on the casing. The casing and stretched tread is encircled with a clamping assembly and, with use of such assembly and without rotating the casing or tread relative to such clamping assembly, the stretched, annular tread is clamped to the casing at a number of points. Pads in the clamping assembly then are retracted, and the annular tread is transferred from the supporting device onto the casing by moving the supporting device axially away from the casing.