Patents by Inventor Robert A. Kramer

Robert A. Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180134770
    Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicant: Merus N.V.
    Inventors: Ton LOGTENBERG, Mark THROSBY, Robert A. KRAMER, Rui D. PINTO, Cornelis A. DE KRUIF, Erwin HOUTZAGER
  • Patent number: 9944695
    Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: April 17, 2018
    Assignee: Merus N.V.
    Inventors: Ton Logtenberg, Mark Throsby, Robert A. Kramer, Rui Daniel Pinto, Cornelis A. De Kruif, Erwin Houtzager
  • Publication number: 20180031555
    Abstract: Described are combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. Further provided are methods for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.
    Type: Application
    Filed: July 18, 2017
    Publication date: February 1, 2018
    Applicant: Merus N.V.
    Inventors: Hendricus Renerus Hoogenboom, Ton Logtenberg, Mark Throsby, Robert A. Kramer, Rui Daniel Pinto, Cornelis A. de Kruif, Erwin Houtzager
  • Patent number: 9765133
    Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 19, 2017
    Assignee: Merus N.V.
    Inventors: Ton Logtenberg, Mark Throsby, Robert A. Kramer, Rui Daniel Pinto, Cornelis A. De Kruif, Erwin Houtzager
  • Publication number: 20170211033
    Abstract: Various embodiments of the present invention pertain to methods for biological production of hydrogen. More specifically, embodiments of the present invention pertain to a modular energy system and related methods for producing hydrogen using organic waste as a feed stock.
    Type: Application
    Filed: November 21, 2016
    Publication date: July 27, 2017
    Applicant: Purdue Research Foundation
    Inventors: Robert Kramer, Libbie S. Pelter, John A. Patterson
  • Patent number: 9506084
    Abstract: Various embodiments of the present invention pertain to methods for biological production of hydrogen. More specifically, embodiments of the present invention pertain to a modular energy system and related methods for producing hydrogen using organic waste as a feed stock.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: November 29, 2016
    Assignee: Purdue Research Foundation
    Inventors: Robert Kramer, Libbie S. Pelter, John A. Patterson
  • Patent number: 9428572
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the molecules. The molecules can be used, for example, in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 30, 2016
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Mark Throsby, Robert A. Kramer, Cornelis A. de Kruif
  • Publication number: 20160238600
    Abstract: Described are combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. Further provided are methods for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.
    Type: Application
    Filed: April 27, 2016
    Publication date: August 18, 2016
    Applicant: Merus B.V.
    Inventors: Hendricus Renerus Hoogenboom, Ton Logtenberg, Mark Throsby, Robert A. Kramer, Rui Daniel Pinto, Cornelis A. de Kruif, Erwin Houtzager
  • Publication number: 20160226951
    Abstract: The embodiments described herein generally relate to a protocol for implementing data operations, e.g., a version of SMB, atop RDMA transports. In embodiments, systems and methods use the protocol definition, which specifies new messages for negotiating an RDMA connection and for transferring SMB2 data using the negotiated communication. A new protocol message may include new header information to determine message size, number of messages, and other information for sending the SMB2 data over RDMA. The header information is used to accommodate differences in message size requirements between RDMA and SMB2. The SMB Direct protocol allows SMB2 data to be fragmented into multiple individual RDMA messages that a receiver may then logically concatenate into a single SMB2 request or SMB2 response. The SMB Direct protocol also may allow SMB2 to transfer application data via efficient RDMA direct placement and to signal the application data's availability when the transfer is complete.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 4, 2016
    Applicant: Microsoft Technology Licensing, LLC
    Inventors: Thomas M. Talpey, Gregory Robert Kramer, David Matthew Kruse
  • Patent number: 9331955
    Abstract: The embodiments described herein generally relate to a protocol for implementing data operations, e.g., a version of SMB, atop RDMA transports. In embodiments, systems and methods use the protocol definition, which specifies new messages for negotiating an RDMA connection and for transferring SMB2 data using the negotiated communication. A new protocol message may include new header information to determine message size, number of messages, and other information for sending the SMB2 data over RDMA. The header information is used to accommodate differences in message size requirements between RDMA and SMB2. The SMB Direct protocol allows SMB2 data to be fragmented into multiple individual RDMA messages that a receiver may then logically concatenate into a single SMB2 request or SMB2 response. The SMB Direct protocol also may allow SMB2 to transfer application data via efficient RDMA direct placement and to signal the application data's availability when the transfer is complete.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: May 3, 2016
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Thomas M. Talpey, Gregory Robert Kramer, David Matthew Kruse
  • Patent number: 9068123
    Abstract: A new approach to the production of coke. In this process multiple optimized value streams are produced from a coke facility located at mine mouth or locally at an existing plant. As part of the process, lower cost Indiana/Illinois Basin-type coals are blended with conventional metallurgical coals. The blending process is optimized to meet coke quality requirements and simultaneously to obtain a pyrolysis gas composition suitable for production of ancillary products including liquid transportation fuels, fertilizer, hydrogen, and electricity. By using lower cost Indiana/Illinois Basin coal it is possible to reduce net coal costs. This process provides a new direction and approach for the production of coke in the future that optimizes value over multiple product streams while reducing both business and technological risk.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 30, 2015
    Assignee: Purdue Research Foundation
    Inventors: Robert A. Kramer, Libbie S. W. Pelter, Harvey Abramowitz, Hardarshan S. Valia, Allen Ellis
  • Patent number: 8888055
    Abstract: A stake for keeping a bag mouth holder and opener and refuse bag in combination secured to the ground in a fixed position whereby the bag mouth holder and opener has the general shape of a rectangular perimeter of a hyperbolic paraboloid to which the stake can be removably attached or integrally connected such that the stake can be driven in to the ground when the bag mouth holder and opener is positioned in the mouth of a bag.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: November 18, 2014
    Inventor: Ross Robert Kramer
  • Publication number: 20140317766
    Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 23, 2014
    Inventors: Ton LOGTENBERG, Mark THROSBY, Robert A. KRAMER, Rui Daniel PINTO, Cornelis A. DE KRUIF, Erwin HOUTZAGER
  • Publication number: 20140314755
    Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
    Type: Application
    Filed: April 30, 2014
    Publication date: October 23, 2014
    Inventors: Ton LOGTENBERG, Mark THROSBY, Robert A. KRAMER, Rui Daniel PINTO, Cornelis A. DE KRUIF, Erwin HOUTZAGER
  • Patent number: 8826209
    Abstract: Defect characterization is a useful tool for analyzing and improving fabrication for semiconductor chips. By using layout and netlist in combination with images of semiconductors, defects can be identified and analyzed. Electrical simulation can be performed on the netlist, based on the presence of the defect that was detected. Layout geometries where the defect was detected can be binned and a search can be performed of the remainder of the layout for similar groupings of layout geometries. Various representations of the semiconductor can be cross mapped, including layout, schematic, and netlist. The presence of certain defects can be correlated to yield, performance, and other characteristics.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: September 2, 2014
    Assignee: Synopsys, Inc.
    Inventors: James Robert Kramer, Ankush Oberai
  • Publication number: 20140157777
    Abstract: Various embodiments of the present invention pertain to methods for biological production of hydrogen. More specifically, embodiments of the present invention pertain to a modular energy system and related methods for producing hydrogen using organic waste as a feed stock.
    Type: Application
    Filed: May 10, 2013
    Publication date: June 12, 2014
    Applicant: Purdue Research Foundation
    Inventors: Robert Kramer, Libbie S. Pelter, John A. Patterson
  • Publication number: 20140099320
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the molecules. The molecules can be used, for example, in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 10, 2014
    Applicant: Crucell Holland B.V.
    Inventors: Mark Throsby, Robert A. Kramer, Cornelis A. de Kruif
  • Patent number: 8690964
    Abstract: A method for treating a fabric for protection from ultraviolet radiation is disclosed which comprises the steps of dispensing a suspension of zinc oxide particles treated with an acid polymer into a washing machine during a time in which a fabric is being washed in the washing machine and mixing the treated zinc oxide particles and the fabric for the treated zinc oxide particles to bind to the fabric. Other methods for treating a fabric for protection from ultraviolet radiation are also disclosed.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: April 8, 2014
    Assignee: The Sweet Living Group, LLC
    Inventors: Robert Kramer, Ronald Kramer, Nicholas Marshall
  • Patent number: 8608807
    Abstract: An ecological fabric having protection from ultraviolet radiation incorporated therein is disclosed in which the fabric is treated by a method comprising the steps of dissolving zinc acetate or other zinc salt in a liquid to form a solution containing Zn(II) ions, adding a fabric to the solution, mixing the solution and the fabric, and adding a base to the solution when the solution and the fabric are being mixed to form a suspension of zinc oxide nanoparticles in contact with the fabric. Other methods are disclosed such as modifying a fabric by carboxylation or phosphorylation of the fabric followed by binding of the UV-blocking nanoparticles to the modified fabric and modifying UV-blocking nanoparticles with a self-assembled monolayer (SAM) or polymer layer containing an active chemical group capable of binding to the fabric and depositing the UV-blocking nanoparticles on the fabric.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: December 17, 2013
    Assignee: The Sweet Living Group, LLC
    Inventors: Robert Kramer, Ronald Kramer, Nicholas Marshall
  • Publication number: 20130248678
    Abstract: A stake for keeping a bag mouth holder and opener and refuse bag in combination secured to the ground in a fixed position whereby the bag mouth holder and opener has the general shape of a rectangular perimeter of a hyperbolic paraboloid to which the stake can be removably attached or integrally connected such that the stake can be driven in to the ground when the bag mouth holder and opener is positioned in the mouth of a bag.
    Type: Application
    Filed: March 18, 2013
    Publication date: September 26, 2013
    Inventor: Ross Robert Kramer