Abstract: Disclosed are limb prostheses for use when normal use of the lower leg is temporarily or permanently lost due to lower leg injury or disease, including below-knee amputation. Disclosed prostheses provide full body weight support and allow a wearer to maintain the use of the hands and arms during ambulation. In addition, a wearer can maintain use of their own knee to flex and extend during ambulation, thereby better controlling the prosthesis during motion and providing a more normal gait as compared to previously known devices. In the event of permanent loss of the lower leg due to below-knee amputation, the disclosed prosthesis provides an alternative to socket-type prosthetic devices.

Abstract: The present invention is generally directed to compositions useful in preventing and/or treating disease due to infection by any of a variety of biologically active pathogenic microorganisms. The compositions include nanoparticles formed of a hydrophobic polymeric core, hydrophilic linking agents bound to the core, and biofunctional materials bound to the linking agents. The biofunctional materials are functionally identical to receptors on host cell surfaces that can be recognized and bound by adhesins on the surface of the targeted pathogenic adhesin-bearing microorganisms. In one embodiment, the binding action between the nanoparticles and the microorganisms can lead to the formation of large agglomerated complexes, which can then be easily removed from an area, including the digestive tract of an infected individual.

Abstract: An intraurethral device for use in a female urinary tract is provided. The intraurethral device comprises a urethral element that contains a chemical compound capable of treating or detecting the presence or absence of a disorder or disease. In one embodiment, the intraurethral device also contains outer and inner insertion elements that are in operative communication with the urethral element to facilitate the insertion of the urethral element into the urethra without substantially contaminating the chemical compound prior to insertion.

Abstract: An intraurethral device that can be used to inhibit leakage of urine due to incontinence is provided. The intraurethral device can include a urethral plug made from a biocompatible, flexible material. The intraurethral device can also include a first insertion element in operative communication with a second insertion element to facilitate self-insertion of the urethral plug into the urethra. Furthermore, in some instances, various mechanisms can be provided to keep the intraurethral device substantially sterile and/or clean prior to and/or during the insertion process.

Abstract: An intra-urethral device that can be used to inhibit leakage of urine due to incontinence is provided. The intra-urethral device can include a urethral plug made from a biocompatible, flexible material, and can be formed into an oblong shape so as to better correspond to the contours of the female urinary tract. In some instances, the intra-urethral device can also include an insertion element that can facilitate self-insertion and the ability of a fluid seal to form between the urethral plug and the walls of the urethra. Furthermore, in some instances, various mechanisms can be provided to keep the intra-urethral device substantially sterile throughout the insertion process.

Abstract: A surgical awl is provided for orthopaedic applications that include creating or enlarging holes in bone. The awl has a shaft and a cutting tip that has a working end and an opposite attachment end, which mechanically locks in place into a recess formed in the end of the shaft opposite the handle. A release mechanism is provided to allow the user to selectively disengage the cutting tip from the shaft. The awl has a hole-retention sleeve which surrounds at least part of the awl shaft and the awl tip and could be configured to surround the entire shaft and tip. The retention sleeve has a forward cutting edge. A protective sleeve may be used in place of the retention sleeve to protect the manual awl tip release mechanism from being accidentally activated to release the awl tip.

Abstract: A femoral intramedullary rod has a thin or reduced proximal segment so as to provide room for the use of femoral hip screws. Use of the rod for femoral shaft fixation permits subsequent independent treatment of an ipsilateral femoral hip fracture as an isolated injury, regardless of whether initially detected. Different rod embodiments are formed by the omission of different proximal portions of the rod. It is in such portions that the femoral screws may be placed to set hip fractures. The rod is cannulated for installation over a guide wire. Internal rod threads, below the thin proximal segment in some embodiments, are used for initial installation of the rod with a driving member screwed into such threads. Without driving forces on the thin proximal segment, such segment can be made even thinner. Once the rod is seated, hip screws may be installed if there is a detected hip fracture. Subsequent to healing, the femoral screws and interlocking screws (if any) may be removed.

Abstract: A femoral intramedullary rod has a thin or reduced proximal segment so as to provide room for the use of femoral hip screws. Use of the rod for femoral shaft fixation permits subsequent independent treatment of an ipsilateral femoral hip fracture as an isolated injury, regardless of whether initially detected. Different rod embodiments are formed by the omission of different proximal portions of the rod. It is in such portions that the femoral screws may be placed to set hip fractures. The rod is cannulated for installation over a guide wire. Internal rod threads, below the thin proximal segment in some embodiments, are used for initial installation of the rod with a driving member screwed into such threads. Without driving forces on the thin proximal segment, such segment can be made even thinner. Once the rod is seated, hip screws may be installed if there is a detected hip fracture. Subsequent to healing, the femoral screws and interlocking screws (if any) may be removed.

Abstract: Mechanical testing apparatus and methods are disclosed for providing closed-loop dynamic mechanical testing under small loads. The testing machine includes an electrically-driven actuator and light weight load transducer. The load transducer converts the applied load into a voltage feedback signal, which is then fed into a closed-loop control means for regulating the applied load in response, in part, to the voltage feedback signal. The testing machine is extremely sensitive and is capable of testing samples with an applied load force of less than about 20 grams.