Patents by Inventor Robert A. Nicolotti

Robert A. Nicolotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coupling agents for joining radionuclide metal ions with biologically useful proteins
    Patent number: 5082930
    Abstract: This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: January 21, 1992
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Robert A. Nicolotti, Richard T. Dean
  • Coupling agents for joining radionuclide metal ions with biologically useful proteins
    Patent number: 4861869
    Abstract: This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide metal ions to provide materials useful for in vivo diagnostic and therapeutic applications.
    Type: Grant
    Filed: May 29, 1986
    Date of Patent: August 29, 1989
    Assignee: Mallinckrodt, Inc.
    Inventors: Robert A. Nicolotti, Richard T. Dean
  • Radiolabeled antibody fragments
    Patent number: 4837003
    Abstract: Methods and reagents for attaching radionuclide metal ions to antibody fragments are disclosed. A coupling agent is employed which contains a maleimidyl group linked, through a divalent organic moiety, to a group capable of forming a chelate complex with the radionuclide metal ion. Antibody fragments labeled with radionuclide metal ions by the disclosed procedure are useful for in vivo diagnostic or therapeutic applications.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: June 6, 1989
    Assignee: Mallinckrodt, Inc.
    Inventor: Robert A. Nicolotti
  • Metal ion labeling of carrier molecules
    Patent number: 4732974
    Abstract: A conjugate of a protein or polypeptide and a metal ion is prepared by reacting a metal ion transfer complex comprising a chelate of 4,5-dihydroxyl-m-benzenedisulfonic acid or a salt thereof with a protein or polypeptide that is covalently bound to an exogenous chelating group having a greater affinity than 4,5-dihydroxyl-m-benzenedisulfonic acid for the metal ion.
    Type: Grant
    Filed: March 5, 1986
    Date of Patent: March 22, 1988
    Assignee: Mallinckrodt, Inc.
    Inventors: Robert A. Nicolotti, Alan R. Ketring, Koon Y. Pak
  • Coupling agents for radiolabeled antibody fragments
    Patent number: 4659839
    Abstract: Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.
    Type: Grant
    Filed: October 10, 1984
    Date of Patent: April 21, 1987
    Assignee: Mallinckrodt, Inc.
    Inventors: Robert A. Nicolotti, Richard T. Dean