Patents by Inventor Robert A. Obar
Robert A. Obar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8846047Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: GrantFiled: October 4, 2010Date of Patent: September 30, 2014Assignee: The Feinstein Institute for Medical ResearchInventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Publication number: 20110217292Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: ApplicationFiled: October 4, 2010Publication date: September 8, 2011Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Patent number: 7632500Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: GrantFiled: September 20, 2007Date of Patent: December 15, 2009Assignee: Cornerstone Therapeutics, Inc.Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Publication number: 20090148453Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: ApplicationFiled: October 15, 2007Publication date: June 11, 2009Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Publication number: 20080113385Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: ApplicationFiled: September 20, 2007Publication date: May 15, 2008Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Patent number: 7288250Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: GrantFiled: September 10, 2004Date of Patent: October 30, 2007Assignee: Critical Therapeutics, Inc.Inventors: Walter Newman, Shixin Qin, Theresa L. O'Keefe, Robert A. Obar
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Publication number: 20050164313Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.Type: ApplicationFiled: May 18, 2004Publication date: July 28, 2005Inventors: Susan Keesee, Robert Obar, Ying-Jye Wu
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Publication number: 20050152903Abstract: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.Type: ApplicationFiled: September 10, 2004Publication date: July 14, 2005Applicant: Critical Therapeutics, Inc.Inventors: Walter Newman, Shixin Qin, Theresa O'Keefe, Robert Obar
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Patent number: 6803189Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.Type: GrantFiled: May 17, 1999Date of Patent: October 12, 2004Assignee: Matritech, Inc.Inventors: Susan K. Keesee, Robert Obar, Ying-Jye Wu
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Publication number: 20030157482Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.Type: ApplicationFiled: May 17, 1999Publication date: August 21, 2003Inventors: SUSAN K. KEESEE, ROBERT OBAR, YING-JYE WU
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Patent number: 6448387Abstract: Arrays of polynucleotide or polypeptide target molecules immobilized on a surface of a substrate where the target molecules are arranged in the array according to intensity of organism expression of cognate probe molecules which hybridize to the target molecules. For instance, target molecules having a higher than average indicia of hybridization, e.g. at least a factor of 2, are segregated at a peripheral region of the substrate and at a lower surface density. Preferred arrays can contain animal, plant or microorganism target molecules including Aspergillus nidulans. Diagnostic arrays can comprise targets from mixed species, e.g. human, mouse and virus; plant breeding arrays can comprise targets from mixed plants, e.g. Arabidopsis thaliana, maize, soy, cotton, wheat, rice, canola and potato.Type: GrantFiled: December 18, 2000Date of Patent: September 10, 2002Assignee: Monsanto Technology, LLCInventors: Caroline Slater, Jeffrey P Cambray, Robert A. Obar
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Patent number: 6218131Abstract: Disclosed are proteins indicative of breast cancer and of other cancers, and methods for their detection. Methods of the invention provide an improvement in cancer detection assays, especially in breast cancer detection assays.Type: GrantFiled: October 6, 1997Date of Patent: April 17, 2001Assignee: Matritech, Inc.Inventors: Susan K. Keesee, Robert Obar, Ying-Jye Wu
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Patent number: 6027905Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.Type: GrantFiled: December 11, 1997Date of Patent: February 22, 2000Assignee: Matritech, Inc.Inventors: Susan K. Keesee, Robert Obar, Ying-Jye Wu
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Patent number: 5914238Abstract: Provided are materials and methods for early diagnosis of breast cancer by detection of breast cancer-associated proteins.Type: GrantFiled: June 5, 1996Date of Patent: June 22, 1999Assignee: Matritech, Inc.Inventors: Susan K. Keesee, Robert Obar, Ying-Jye Wu
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Patent number: 5858683Abstract: The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.Type: GrantFiled: August 30, 1996Date of Patent: January 12, 1999Assignee: Matritech, Inc.Inventors: Susan K. Keesee, Robert Obar, Ying-Jye Wu