Patents by Inventor Robert A. Reamer

Robert A. Reamer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rearrangement process and tricyclic and tetracyclic compounds
    Patent number: 6268510
    Abstract: A rearrangement process for the preparation of a 6,5,5-tricyclic, a 6,6,5-tricyclic and 6,5,5,7-tetracyclic ring system is disclosed.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: July 31, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Lisa F. Frey, Edward J. J. Grabowski, Stephane G. Ouellet, Robert A. Reamer, Richard D. Tillyer
  • Process for synthesis of FK-506 and tricarbonyl intermediates
    Patent number: 5446158
    Abstract: A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: August 29, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Todd K. Jones, Sander G. Mills, David Askin, Robert A. Reamer, Richard Desmond, David M. Tschaen, Ralph P. Volante, Ichiro Shinkai
  • Process for the preparation of imidazolutidine
    Patent number: 5424432
    Abstract: This invention relates to a method for the preparation of a compound of formula I: ##STR1## a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: June 13, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Laura E. Fredenburgh, Robert D. Larsen, Ji Liu, Robert A. Reamer, Chris H. Senanayake, Thomas R. Verhoeven
  • Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis
    Patent number: 5314898
    Abstract: Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: May 24, 1994
    Assignees: Merck & Co., Inc., Merck Frosst Canada Inc.
    Inventors: John Y. L. Chung, Robert A. Reamer, Yves Girard, Pierre Hamel
  • Phosphorylated cyclic lipopeptide
    Patent number: 5198421
    Abstract: There is disclosed a monophosphorylated cyclic lipopeptide compound obtained by biophosphorylating a cyclic lipopeptide related to echinocandins and having a peptide skeleton bearing several hydroxy groups wherein in the phosphorylated cyclic lipopeptide, the phosphate group is attached to the hydroxy group of the 4-hydroxyproline component of the lipopeptide. The compounds are useful for the control of fungi and parasites.
    Type: Grant
    Filed: April 26, 1991
    Date of Patent: March 30, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, David J. Mathre, Brian R. Petuch, Robert A. Reamer
  • Hydroxide mediated FK-506 rearrangement product
    Patent number: 4980466
    Abstract: A process is described involving an alkaline rearrangement of FK-506 producing a new decarbonylated 22-membered macrocycle rearrangement derivative of FK-506, i.e. C.9, nor-keto FK-506.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: December 25, 1990
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Todd K. Jones, Robert A. Reamer, Ralph P. Volante, Ichiro Shinkai
  • Novel hydroxide mediated FK-506 rearrangement process
    Patent number: 4920218
    Abstract: A process is described involving an alkaline rearrangement of FK-506 producing a new decarbonylated 22-membered macrocycle rearrangement derivative of FK-506, i.e. C.9, nor-keto FK-506.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: April 24, 1990
    Assignee: Merck & Co., Inc.
    Inventors: David Askin, Todd K. Jones, Robert A. Reamer, Ralph P. Volante, Ichiro Shinkai
  • Process for unsymmetrical dithioacetals and dithioketals
    Patent number: 4883878
    Abstract: This invention relates to a novel process for preparing unsymmetrical dithioacetals and dithioketals from aryl aldehydes and ketones.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: November 28, 1989
    Assignee: Merck & Co. Inc.
    Inventors: Joseph S. Amato, James M. McNamara, Johnnie L. Leazer, Jr., Paul J. Reider, Robert A. Reamer
  • Antihypercholesterolemic agents
    Patent number: 4719229
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents are represented by the following structural formulae (I) and (II): ##STR1## are disclosed.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: January 12, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Robert A. Reamer, Laszlo R. Treiber
  • Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
    Patent number: 4329481
    Abstract: Disclosed is 2 and a process for its preparation: ##STR1## It is useful in the synthesis of N-formimidoyl thienamycin; R.sup.2 is hydrogen or a protecting group.
    Type: Grant
    Filed: April 17, 1981
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, Robert A. Reamer, Ichiro Shinkai, Meyer Sletzinger
  • Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
    Patent number: 4292436
    Abstract: Disclosed is 2 and a process for its preparation: ##STR1## It is useful in the synthesis of N-formimidoyl thienamycin; R.sup.2 is hydrogen or a protecting group.
    Type: Grant
    Filed: June 25, 1980
    Date of Patent: September 29, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Thomas M. H. Liu, Robert A. Reamer, Ichiro Shinkai, Meyer Sletzinger