Abstract: A universal, self-contained, self-powered, compact, external vacuum source and cytology or cytology and histology collection, storage, preservation and transport system device may be configured to couple to any suitable generic biopsy or interventional device. Embodiments may comprise structures and functionality for the addition of such a portable, compact, self-contained, self-powered, universal vacuum and cytology/histology collection module to biopsy or interventional devices. Embodiments may be portable, disposable or reusable and may be electrically, mechanically and/or manually powered and operated. Embodiments may additionally provide structures and functionality for use with other vacuum and/or cytology or histology collection systems to which this system may itself be attached.

Abstract: Systems and methods for rendering spatial audio in accordance with embodiments of the invention are illustrated. One embodiment includes a spatial audio system, including a primary network connected speaker, including a plurality of sets of drivers, where each set of drivers is oriented in a different direction, a processor system, memory containing an audio player application, wherein the audio player application configures the processor system to obtain an audio source stream from an audio source via the network interface, spatially encode the audio source, decode the spatially encoded audio source to obtain driver inputs for the individual drivers in the plurality of sets of drivers, where the driver inputs cause the drivers to generate directional audio.

Abstract: A turbocharger housing has a valve device. The valve device is formed with at least one first duct section and a second duct section. The two duct sections are arranged with their longitudinal axes parallel to one another and they are formed without any undercuts.

Abstract: A turbocharger housing has a valve device. The valve device is formed with at least one first duct section and a second duct section. The two duct sections are arranged with their longitudinal axes parallel to one another and they are formed without any undercuts.

Abstract: A heat shield, in particular for a turbocharger, has a disk or a pot shape which is stepped once or multiple times. The disc or pot shape has an outer edge, and the outer edge is provided with at least one opening section. The opening section forms a web section with the outer edge, said web section being bent outward in order to form a spring arm. The web section is either designed as closed or as open at one point.

Abstract: A housing of a turbo charger has a turbine housing and a bearing housing. A cooling jacket is formed of at least one or more shell elements that are fixed to the outside of the housing and that form therewith a cavity into which a coolant can be introduced.

Abstract: Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) and use of the same to obtain a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

Abstract: The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

Abstract: Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) and use of the same to obtain a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

Abstract: Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) for a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

Abstract: The invention relates to a process for the inhibition of the DNA synthesis (essential for the proliferation) of human fibroblasts by a single or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipeptidyl peptidase IV (DPIV) expressed by those cells. The DNA synthesis (proliferation) of human fibroblasts is inhibited, in a dose dependent manner, by an administration of inhibitors of APN or/and DPIV. The invention shows that the application of substances inhibiting the above enzymes or of compositions and administration forms thereof are well suitable for a therapy and a prevention of dermatological diseases associated with fibroblast hyperproliferation and changed fibroblast differentiation states.

Abstract: The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.

Abstract: The present invention relates to the use of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specifity (DP IV-analogous enzymatic activity) in combination with inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specifity (APN-analoguos enzymatic activity) for a more than additive to superadditive inhibition of the activation and proliferation (DNA synthesis) of human T lymphocytes and mononuclear cells and of the production of TH2 cytokines for a therapy and prevention of allergic reactions of the type I according to the Gell and Coombs classification and for a more than additive to super-additive inhibition of the activation, proliferation (DNA synthesis) of human epidermal and follicular keratinocytes and of keratinocytes of the transitional zone between the skin and the mucous membranes as well as for a therapy and prevention of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced prolife

Abstract: A vehicle seat mounting mechanism including oppositely disposed pairs of parallel links between a base and a seat carrier, and a first air bag spring operatively connected between the base and the links for absorbing vertical-upward motion induced by road shocks, and a second air bag spring secured between the base and the seat carrier for absorbing vertical-downward motion induced by road shocks. A separate shock absorber mounted between the base and the seat carrier serves to dampen the springing action of the first and second air bag springs.

Abstract: The packaging machine for producing packages from a packaging material web has a feeding chain for feeding the web. The endless feeding chain is mounted on spaced sprocket wheels and has chain links provided with improved clamping members for clamping the web at one of its lateral edges. The clamping members include on each chain link a first clamping member secured on or integral with the associated chain link, a cooperating second clamping member having a guiding shaft guided in a guiding opening of the first clamping member, a flanged sleeve surrounding the guiding shaft with its flange portion adjacent the first clamping member and a pressure spring engaging between the flange portion and an abutment member mounted on one end of the guiding shaft opposed to the second clamping member.