Patents by Inventor Robert Arjen Kramer

Robert Arjen Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED HUMAN VARIABLE DOMAINS
    Publication number: 20220281957
    Abstract: The present invention provides polypeptides comprising modified human, humanized, or chimeric immunoglobulin heavy chain variable domains. Corresponding antibodies, variants, fragments, nucleic acids, vectors, phages, libraries, methods and kits are also provided.
    Type: Application
    Filed: August 4, 2020
    Publication date: September 8, 2022
    Inventors: Peter Brian Silverman, Robert Arjen Kramer, Alexander Berthold Henrik Bakker
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Patent number: 9005624
    Abstract: Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 14, 2015
    Assignee: Crucell Holland B.V.
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Human binding molecules against and
    Patent number: 8628776
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: January 14, 2014
    Assignee: Crucell Holland B.V.
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • HUMAN BINDING MOLECULES HAVING KILLING ACTIVITY AGAINST ENTEROCOCCI AND USES THEREOF
    Publication number: 20120315278
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Application
    Filed: July 16, 2012
    Publication date: December 13, 2012
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Human binding molecules having killing activity against enterococci and uses thereof
    Patent number: 8241631
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: August 14, 2012
    Assignee: Crucell Holland B.V.
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Patent number: 8148497
    Abstract: The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the post-exposure prophylaxis of rabies.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: April 3, 2012
    Assignee: Crucell Holland B.V.
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan de Kruif
  • Human binding molecules having killing activity against enterococci and uses thereof
    Publication number: 20110268739
    Abstract: Described are human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from Enterococcus.
    Type: Application
    Filed: May 19, 2011
    Publication date: November 3, 2011
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Human binding molecules having killing activity against enterococci and uses thereof
    Patent number: 7960518
    Abstract: The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: June 14, 2011
    Assignee: Crucell Holland B.V.
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Publication number: 20100310572
    Abstract: Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
    Type: Application
    Filed: April 8, 2010
    Publication date: December 9, 2010
    Applicant: Crucell Holland B.V.
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Publication number: 20100272724
    Abstract: The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. Preferably, they can be used in the post-exposure prophylaxis of rabies.
    Type: Application
    Filed: July 6, 2009
    Publication date: October 28, 2010
    Applicant: Crucell Holland B.V.
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Patent number: 7740852
    Abstract: Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: June 22, 2010
    Assignee: Crucell Holland B.V.
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Human Binding Molecules Having Killing Activity Against Enterococci and Uses Thereof
    Publication number: 20090169562
    Abstract: The present invention provides human binding molecules specifically binding to enterococci and having killing activity against enterococci, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from Enterococcus.
    Type: Application
    Filed: June 5, 2007
    Publication date: July 2, 2009
    Inventors: Mark Throsby, Robert Arjen Kramer, Cornelis Adriaan De Kruif
  • Binding molecules capable of neutralizing rabies virus and uses thereof
    Publication number: 20080226652
    Abstract: Provided are binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. Further provided are nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from rabies virus. In certain embodiments, they can be used in the post-exposure prophylaxis of rabies.
    Type: Application
    Filed: October 29, 2007
    Publication date: September 18, 2008
    Inventors: Alexander Berthold Hendrik Bakker, Willem Egbert Marissen, Robert Arjen Kramer, Cornelis Adriaan De Kruif