Patents by Inventor Robert B. Nachbar

Robert B. Nachbar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical structure similarity ranking system and computer-implemented method for same
    Patent number: 7219020
    Abstract: A novel extension of the vector space model for computing chemical similarity is described. In one embodiment, a method calculates similarity between molecules and molecular descriptors using the singular value composition (SVD) of a molecule/descriptor matrix and, for example, an identity matrix, to create a low dimensional representation of the original descriptor space. Probe or query molecules then can be projected into the low dimensional representation and compared to the molecules from the original matrix.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: May 15, 2007
    Assignee: Axontologic, Inc.
    Inventors: Richard D. Hull, Eugene M. Fluder, Jr., Suresh B. Singh, Robert P. Sheridan, Robert B. Nachbar, Simon K. Kearsley
  • Macrocycles incorporating quinazolinones
    Patent number: 5292741
    Abstract: Macrocyclic compounds of general Structure I: ##STR1## Wherein M is C or N are angiotensin II receptor (A-II) antagonists useful in the treatment of certain cardiovascular dysfunctions and ocular hypertension.
    Type: Grant
    Filed: August 18, 1992
    Date of Patent: March 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Stephen E. deLaszlo, Tomasz Glinka, Robert B. Nachbar, Eric E. Allen, Kristine Prendergast