Patents by Inventor Robert Berkowitz
Robert Berkowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8263356Abstract: The present invention relates to antibodies, binding portions thereof, or probes that bind specifically to glucosyltransferase enzymes, and uses of these agents for detecting glucosyltransferase enzyme(s) in a sample and for diagnosing predisposition of a human child to early childhood caries. The present invention also relates to a kit for detecting a glucosyltransferase enzyme in an oral sample from an animal.Type: GrantFiled: August 14, 2006Date of Patent: September 11, 2012Assignee: University of RochesterInventors: William H. Bowen, Anne Vacca Smith, Robert Berkowitz
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Patent number: 8236558Abstract: BIV packaging constructs, BIV packaging cell lines, methods of making BIV packaging cells and methods of making BIV producer cells are described.Type: GrantFiled: August 30, 2010Date of Patent: August 7, 2012Assignee: Novartis AGInventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20110123971Abstract: An audible medical information system for a patient or other lay user that is loaded with content by a company or the health care practitioner and can be played at will by the patient and a means for recording information in the audio file. In one embodiment, the system records information in a physical card that the user can have with them without the need for any electronic devices such as a computer or smart phone. Other embodiments may include electronic audio or video files delivered to a computer or smart phone. The audio file can contain up to several minutes of audible information, some of which may be patient specific and some of which may be disease or medication specific. The information may include pre- or post-surgical instructions, information about medications or basic use instructions for medical devices. The file(s), which can play when a card is opened (note card format) or a button is pressed (credit card or digital format), will repeat the information as the user desires.Type: ApplicationFiled: November 21, 2010Publication date: May 26, 2011Applicant: Medivoce, Inc.Inventors: Robert Berkowitz, Karen Drexler, Stephen Dixon Bristow, Robert Lewis Anderson
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Patent number: 7785877Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: GrantFiled: March 8, 2005Date of Patent: August 31, 2010Assignee: Novartis AGInventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20070207546Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: ApplicationFiled: December 14, 2006Publication date: September 6, 2007Applicant: Novartis AGInventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20070065886Abstract: The present invention relates to antibodies, binding portions thereof, or probes that bind specifically to glucosyltransferase enzymes, and uses of these agents for detecting glucosyltransferase enzyme(s) in a sample and for diagnosing predisposition of a human child to early childhood caries. The present invention also relates to a kit for detecting a glucosyltransferase enzyme in an oral sample from an animal.Type: ApplicationFiled: August 14, 2006Publication date: March 22, 2007Applicant: UNIVERSITY OF ROCHESTERInventors: William Bowen, Anne Vacca Smith, Robert Berkowitz
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Publication number: 20060019394Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: ApplicationFiled: March 8, 2005Publication date: January 26, 2006Inventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20050208660Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: ApplicationFiled: March 8, 2005Publication date: September 22, 2005Inventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20050148078Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: ApplicationFiled: March 8, 2005Publication date: July 7, 2005Inventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20050148077Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.Type: ApplicationFiled: March 8, 2005Publication date: July 7, 2005Inventors: Tianci Luo, Robert Berkowitz, Michael Kaleko
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Publication number: 20030215460Abstract: This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.Type: ApplicationFiled: May 7, 2002Publication date: November 20, 2003Inventors: Thomas J. Schall, Zhenhua Miao, Robert Berkowitz, Zheng Wei, Maureen Howard, Brett Premack
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Publication number: 20030108515Abstract: This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies for therapeutic or diagnostic use).Type: ApplicationFiled: October 30, 2001Publication date: June 12, 2003Inventors: Thomas J. Schall, Maureen Howard, Robert Berkowitz, Brett Premack, Dale Talbot