Patents by Inventor Robert C. Doss
Robert C. Doss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210270840Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.Type: ApplicationFiled: December 23, 2020Publication date: September 2, 2021Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
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SYSTEMS AND METHODS OF USING MACHINE LEARNING ANALYSIS TO STRATIFY RISK OF SPONTANEOUS PRETERM BIRTH
Publication number: 20210057039Abstract: The present disclosure relates to systems and methods of using machine learning analysis to stratify the risk of spontaneous preterm birth (SPTB). In some variations, to select informative markers that differentiate SPTB from term deliveries, a processed quantification data of the markers can be subjected to univariate receiver operating characteristic (ROC) curve analysis. A Differential Dependency Network (DDN) can then applied in order to extract co-expression patterns among the markers. In order to assess the complementary values among selected markers and the range of their relevant performance, multivariate linear models can be derived and evaluated using bootstrap resampling.Type: ApplicationFiled: July 31, 2020Publication date: February 25, 2021Inventors: Brian D. BROHMAN, Zhen ZHANG, Robert C. DOSS, Kevin Paul ROSENBLATT -
Publication number: 20210050112Abstract: Disclosed herein are methods and systems for determining risk of preeclampsia. The system can include (a) a computer comprising: (i) a processor; and (II) a memory, coupled to the processor, the memory storing a module comprising: (1) test data for a sample from a subject including values indicating a quantitative measure of one or more markers; (2) a classification rule which, based on values including the measurements, classifies the subject as being at risk of preeclampsia, wherein the classification rule is configured to have a sensitivity of at least 75%, at least 85% or at least 95%; and (3) computer executable instructions for implementing the classification rule on the test data.Type: ApplicationFiled: July 31, 2020Publication date: February 18, 2021Inventors: Kevin P. ROSENBLATT, Thomas F. MCELRATH, Brian D. BROHMAN, Robert C. DOSS
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Patent number: 10877046Abstract: Provided herein are proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, provided are tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.Type: GrantFiled: June 4, 2018Date of Patent: December 29, 2020Assignee: NX PRENATAL INC.Inventors: Brian D. Brohman, Zhen Zhang, Kevin S. Goudy, Robert C. Doss, Alan M. Ezrin, Kevin Paul Rosenblatt
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Publication number: 20190041391Abstract: The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.Type: ApplicationFiled: June 4, 2018Publication date: February 7, 2019Inventors: Brian D. BROHMAN, Zhen ZHANG, Kevin S. GOUDY, Robert C. DOSS, Alan M. EZRIN, Kevin Paul ROSENBLATT
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Patent number: 8658384Abstract: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.Type: GrantFiled: June 25, 2013Date of Patent: February 25, 2014Assignee: Abbott LaboratoriesInventors: Saul A. Datwyler, Jessie W. Shih, Robert C. Doss, Walter J. Keirans, Sudarshan Hebbar
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Publication number: 20130288269Abstract: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Applicant: ABBOTT LABORATORIESInventors: Saul A. Datwyler, Jessie W. Shih, Robert C. Doss, Walter J. Keirans, Sudarshan Hebbar
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Patent number: 8501420Abstract: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.Type: GrantFiled: August 30, 2010Date of Patent: August 6, 2013Assignee: Abbott LaboratoriesInventors: Saul A. Datwyler, Jessie W. Shih, Robert C. Doss, Walter J. Keirans, Sudarshan Hebbar
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Publication number: 20120302458Abstract: Provided herein are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease; for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease; and for determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components useful for performing the methods.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Applicant: ABBOTT LABORATORIESInventors: Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss, Phillip G. Mattingly
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Patent number: 8173382Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: GrantFiled: August 17, 2010Date of Patent: May 8, 2012Assignee: Abbott LaboratoriesInventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss
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Publication number: 20110229921Abstract: A method of prognosticating cadaveric kidney transplant function in a patient; a method of prognosticating cadaveric kidney transplant function in a patient diagnosed with DGF; a method of assessing risk of DGF in a patient, who has been diagnosed with EGF; and a kit comprising at least one component for assaying urine from a patient for NGAL and instructions for assaying the urine for NGAL and assessing cadaveric kidney transplant function or risk of DGF in the patient.Type: ApplicationFiled: June 9, 2010Publication date: September 22, 2011Applicant: ABBOTT LABORATORIESInventors: Robert C. Doss, Sudarshan Hebbar
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Publication number: 20110053179Abstract: The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac event (MACE) in a patient.Type: ApplicationFiled: August 30, 2010Publication date: March 3, 2011Applicant: ABBOTT LABORATORIESInventors: Saul A. Datwyler, Jessie W. Shih, Robert C. Doss, Walter J. Keirans, Sudarshan Hebbar
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Publication number: 20100311079Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: ApplicationFiled: August 17, 2010Publication date: December 9, 2010Applicant: ABBOTT LABORATORIESInventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss
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Patent number: 7776605Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: GrantFiled: October 26, 2006Date of Patent: August 17, 2010Assignee: Abbott LaboratoriesInventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss
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Publication number: 20090162876Abstract: The present invention relates to methods and kits for determining autoantibodies to myeloperoxidase or a myeloperoxidase fragment and myeloperoxidase or a myeloperoxidase fragment in a test sample.Type: ApplicationFiled: August 29, 2008Publication date: June 25, 2009Applicant: ABBOTT LABORATORIESInventors: Maciej Adamczyk, Robert C. Doss, Phillip G. Mattingly
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Publication number: 20090017560Abstract: Provided herein among other things are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed among other things to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease. The method can be employed for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease, but may with time. In one embodiment, the invention also provides a method of determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: ApplicationFiled: August 28, 2008Publication date: January 15, 2009Applicant: ABBOTT LABORATORIESInventors: Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss, Phillip G. Mattingly
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Publication number: 20080305512Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: ApplicationFiled: November 2, 2007Publication date: December 11, 2008Inventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss
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Publication number: 20080102481Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.Type: ApplicationFiled: October 26, 2006Publication date: May 1, 2008Inventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear, Robert C. Doss