Patents by Inventor Robert C. Kain
Robert C. Kain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240141428Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.Type: ApplicationFiled: October 18, 2023Publication date: May 2, 2024Inventors: Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
-
Publication number: 20240118188Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer. A method is providing including obtaining signal data from an array of light detectors; determining a crosstalk function for each of the light detectors of the array of light detectors; and determining characteristics of analytes of interest based on the signal data using the crosstalk functions.Type: ApplicationFiled: December 18, 2023Publication date: April 11, 2024Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi, Tarun Khurana
-
Publication number: 20240120093Abstract: The present invention provides a novel approach for storing, analyzing, and/or accessing biological data in a cloud computing environment. Sequence data generated by a particular sequencing device may be uploaded to the cloud computing environment during a sequencing run, which reduces the on-site storage needs for the sequence data. Analysis of the data may also be performed in the cloud computing environment, and the instructions for such analysis may be set at the originating sequencing device. The sequence data in the cloud computing environment may be shared according to permissions. Further, the sequence data may be modified or annotated by authorized secondary users.Type: ApplicationFiled: December 19, 2023Publication date: April 11, 2024Inventors: Alexander G. Dickinson, Francisco Jose Garcia, Robert C. Kain, Scott D. Kahn, Andrew R. Nelson
-
Patent number: 11898774Abstract: The misting system has, in one embodiment, two seats with misting heads above each seat. A platform supports the seats, a tank, a pump and a power source. A supply line couples the tank-supplied pump and the misters. Removable canopy is mounted above seats by vertical and curvaceous struts and the misters are mounted on the struts. A user actuated UA control on the seat(s) activates pump ON to release mist. Wheels make the module mobile. Battery, solar power, and chiller are options. A countdown timer turns OFF the pump or controllable, inline valves after initial activation of the UA control. A level sensor in the tank alerts the user via a user display. A pressurized system can be used. Multiple modules coupled together are controlled by a master module with master controls.Type: GrantFiled: January 31, 2023Date of Patent: February 13, 2024Assignee: SINKFIELD AND HART ENTERPRISES, L.L.C.Inventors: Joseph Sinkfield, C. Brian Hart, Robert C. Kain, Sr.
-
Patent number: 11894135Abstract: The present invention provides a novel approach for storing, analyzing, and/or accessing biological data in a cloud computing environment. Sequence data generated by a particular sequencing device may be uploaded to the cloud computing environment during a sequencing run, which reduces the on-site storage needs for the sequence data. Analysis of the data may also be performed in the cloud computing environment, and the instructions for such analysis may be set at the originating sequencing device. The sequence data in the cloud computing environment may be shared according to permissions. Further, the sequence data may be modified or annotated by authorized secondary users.Type: GrantFiled: May 10, 2021Date of Patent: February 6, 2024Assignee: Illumina, Inc.Inventors: Alexander G Dickinson, Francisco Jose Garcia, Robert C. Kain, Scott D. Kahn, Andrew R. Nelson
-
Patent number: 11874214Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer. A method is providing including obtaining signal data from an array of light detectors; determining a crosstalk function for each of the light detectors of the array of light detectors; and determining characteristics of analytes of interest based on the signal data using the crosstalk functions.Type: GrantFiled: March 7, 2023Date of Patent: January 16, 2024Assignee: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi, Tarun Khurana
-
Patent number: 11827932Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.Type: GrantFiled: January 20, 2021Date of Patent: November 28, 2023Assignee: Illumina, Inc.Inventors: Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
-
Publication number: 20230326563Abstract: A system and method are disclosed for the collection and aggregation of genomic, medical, and other data of interest for individuals and populations that may be of interest for analysis, research, pharmaceutical development, medical treatment, and so forth. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Third parties interested in the database information may contribute value (e.g., pay) for access and use. Value flows back to the members and to a system administrative entity.Type: ApplicationFiled: February 2, 2023Publication date: October 12, 2023Inventors: Robert C. Kain, Dawn Mary Barry, David Lewis, Kenneth Robert Bloom, Scott Kahn, Bojil Velinov
-
Publication number: 20230252017Abstract: A system and method are disclosed for the collection and aggregation of data from contributing members of a community, such as health-related, personal, genomic, medical, and other data of interest for individuals and populations. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Steps are taken to determine incompleteness and incorrectness of the data, and the data may be improved or completed automatically, based upon interaction with members, additional contributions of data, and so forth.Type: ApplicationFiled: February 2, 2023Publication date: August 10, 2023Inventor: Robert C. Kain
-
Publication number: 20230220444Abstract: A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.Type: ApplicationFiled: March 22, 2023Publication date: July 13, 2023Inventors: Robert C. Kain, Min-Jui Richard Shen, John A. Moon, Helmy A. Eltoukhy
-
Patent number: 11697847Abstract: A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that includes a subset of at least two of the pads; and (c) an activation circuit to apply a force at a first and second pad in the subset, wherein the activation circuit is configured to apply a different force at the first pad compared to the second pad, and wherein the activation circuit has a switch to selectively alter the force at the first pad and the second pad.Type: GrantFiled: April 1, 2020Date of Patent: July 11, 2023Assignee: ILLUMINA, INC.Inventors: Robert C. Kain, Tarun Khurana, Kevin L. Gunderson, Yir-Shyuan Wu
-
Publication number: 20230194109Abstract: The misting system has, in one embodiment, two seats with misting heads above each seat. A platform supports the seats, a tank, a pump and a power source. A supply line couples the tank-supplied pump and the misters. Removable canopy is mounted above seats by vertical and curvaceous struts and the misters are mounted on the struts. A user actuated UA control on the seat(s) activates pump ON to release mist. Wheels make the module mobile. Battery, solar power, and chiller are options. A countdown timer turns OFF the pump or controllable, inline valves after initial activation of the UA control. A level sensor in the tank alerts the user via a user display. A pressurized system can be used. Multiple modules coupled together are controlled by a master module with master controls.Type: ApplicationFiled: January 31, 2023Publication date: June 22, 2023Inventors: Joseph Sinkfield, C. Brian Hart, Robert C. Kain, SR.
-
Patent number: 11634746Abstract: A portable detector is disclosed for detecting certain analytes of interest, such as genetic material (e.g., nucleic acids). The detector includes a reading component for the detection of the analytes, and control circuitry for controlling operation of the reading component. Processing circuitry may be included to perform both primary analysis of acquired data, and where desired, secondary analysis. Where desired, some or all of the computationally intensive tasks may be off-loaded to enhance the portability and speed of the device. The device may incorporate various types of interface, technologies for reading and analysis, positioning system interfaces, and so forth. A number of exemplary use cases and methods are also disclosed.Type: GrantFiled: August 14, 2019Date of Patent: April 25, 2023Assignee: Illumina, Inc.Inventors: Robert C. Kain, Min-Jui Richard Shen, John A. Moon, Helmy A. Eltoukhy
-
Patent number: 11604775Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.Type: GrantFiled: June 25, 2021Date of Patent: March 14, 2023Assignee: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi, Tarun Khurana
-
Publication number: 20230076823Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.Type: ApplicationFiled: October 27, 2022Publication date: March 9, 2023Applicant: Illumina, Inc.Inventors: Robert C. Kain, David L. Heiner, Chanfeng Zhao, Kevin Gunderson
-
Patent number: 11598538Abstract: The misting system has, in one embodiment, two seats with misting heads above each seat. A platform supports the seats, a tank, a pump and a power source. A supply line couples the tank-supplied pump and the misters. Removable canopy is mounted above seats by vertical and curvaceous struts and the misters are mounted on the struts. A user actuated UA control on the seat(s) activates pump ON to release mist. Wheels make the module mobile. Battery, solar power, and chiller are options. A countdown timer turns OFF the pump or controllable, inline valves after initial activation of the UA control. A level sensor in the tank alerts the user via a user display. A pressurized system can be used. Multiple modules coupled together are controlled by a master module with master controls.Type: GrantFiled: December 21, 2021Date of Patent: March 7, 2023Inventors: Joseph Sinkfield, C. Brian Hart, Robert C. Kain, Sr.
-
Patent number: 11580090Abstract: A system and method are disclosed for the collection and aggregation of data from contributing members of a community, such as health-related, personal, genomic, medical, and other data of interest for individuals and populations. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Steps are taken to determine incompleteness and incorrectness of the data, and the data may be improved or completed automatically, based upon interaction with members, additional contributions of data, and so forth.Type: GrantFiled: April 14, 2020Date of Patent: February 14, 2023Assignee: LunaPBCInventor: Robert C. Kain
-
Patent number: 11574712Abstract: A system and method are disclosed for the collection and aggregation of genomic, medical, and other data of interest for individuals and populations that may be of interest for analysis, research, pharmaceutical development, medical treatment, and so forth. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Third parties interested in the database information may contribute value (e.g., pay) for access and use. Value flows back to the members and to a system administrative entity.Type: GrantFiled: April 8, 2019Date of Patent: February 7, 2023Assignee: LunaPBCInventors: Robert C. Kain, Dawn Mary Barry, David Lewis, Kenneth Robert Bloom, Scott Kahn, Bojil Velinov
-
Patent number: 11499191Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.Type: GrantFiled: August 20, 2018Date of Patent: November 15, 2022Assignee: ILLUMINA, INC.Inventors: Robert C. Kain, David L. Heiner, Chanfeng Zhao, Kevin Gunderson
-
Patent number: 11449492Abstract: A system and method are disclosed for the collection and aggregation of data from contributing members of a community, such as health-related, personal, genomic, medical, and other data of interest for individuals and populations. Contributors become members of a community upon creation of an account and providing of data or files. The data is received and processed, such as to analyze, structure, perform quality control, and curate the data. Value or shares in one or more community databases are computed and attributed to each contributing member. The data is controlled to avoid identification or personalization. Steps are taken to determine incompleteness and incorrectness of the data, and the data may be improved or completed automatically, based upon interaction with members, additional contributions of data, and so forth.Type: GrantFiled: April 30, 2019Date of Patent: September 20, 2022Assignee: LunaPBCInventor: Robert C. Kain