Abstract: A computer-implemented system and method performs an iterative process to assess the installation of an upgrade version of a database product for consistency with a baseline version of the database product. To assess the installation, the baseline version and the upgrade version are reconciled by modifying one or both of the baseline and upgrade versions. The modified baseline and upgrade versions are then analyzed to determine whether any remaining inconsistencies exist. Any remaining inconsistencies are then identified and classified, and reconciled. Thereafter, the process is repeated iteratively until the upgrade version is reconciled with the baseline version.

Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.

Abstract: A computer-implemented system and method performs an iterative process to assess the installation of an upgrade version of a database product for consistency with a baseline version of the database product. To assess the installation, the baseline version and the upgrade version are reconciled by modifying one or both of the baseline and upgrade versions. The modified baseline and upgrade versions are then analyzed to determine whether any remaining inconsistencies exist. Any remaining inconsistencies are then identified and classified, and reconciled. Thereafter, the process is repeated iteratively until the upgrade version is reconciled with the baseline version.

Abstract: The present invention relates to compositions that contain a chimeric papillomavirus virus-like particle (VLP) in combination with a DNA molecule encoding a protein or polypeptide epitope. The chimeric papillomavirus VLP is assembled from an L1 protein or polypeptide and a chimeric protein or polypeptide containing at least a portion of the L2 protein and a protein or polypeptide including an immunogenic epitope. The composition is useful for inducing an enhanced immune response against a pathogen or a tumor.

Abstract: A computer-implemented system and method performs an iterative process to assess the installation of an upgrade version of a database product for consistency with a baseline version of the database product. To assess the installation, the baseline version and the upgrade version are reconciled by modifying one or both of the baseline and upgrade versions. The modified baseline and upgrade versions are then analyzed to determine whether any remaining inconsistencies exist. Any remaining inconsistencies are then identified and classified, and reconciled. Thereafter, the process is repeated iteratively until the upgrade version is reconciled with the baseline version.

Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.

Abstract: The disclosure provides a tetravalent Dengue virus vaccine, and methods of inducing a immune response against a Flavivirus such as Dengue virus 1-4 using the vaccine. The disclosure also provides methods of making a vaccine by introducing into a host cell a transgene that encodes a protein comprising Dengue domain III polypeptides, or, by purified dill polypeptides specific for Dengue serotypes 1-4, Yellow Fever Virus, West Nile Virus, Japanese Encephalitis Virus, and Flaviviruses.

Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.

Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.

Abstract: The present invention is directed to a chimeric papillomavirus virus-like particle (VLP) or capsomere including an L1 polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus (RSV) protein or polypeptide fragment thereof comprising a first epitope, where the RSV protein or polypeptide fragment thereof is attached to one or both of the L1 and L2 polypeptides. Chimeric proteins, genetic constructions, and recombinant vectors and host cells suitable for expression of the constructs and making of the chimeric VLPs or capsomeres are also disclosed. Use of the VLPs or capsomeres, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.

Abstract: The present invention relates to a method of detecting immune enhancement of virus infectivity, a method of determining neutralization and immune enhancement of virus infectivity, a method of identifying a virus epitope that displays immune enhancement, a method of identifying a compound that modulates activity of an Fc receptor, and a method of identifying a compound that modulates intracellular signaling of an Fc receptor. DNA constructs, cells, and kits relating to these assays are also disclosed.

Abstract: The present invention relates to compositions that contain a chimeric papillomavirus virus-like particle (VLP) in combination with a DNA molecule encoding a protein or polypeptide epitope. The chimeric papillomavirus VLP is assembled from an L1 protein or polypeptide and a chimeric protein or polypeptide containing at least a portion of the L2 protein and a protein or polypeptide including an immunogenic epitope. The composition is useful for inducing an enhanced immune response against a pathogen or a tumor.

Abstract: A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.

Abstract: The present invention relates to a method of vaccinating a mammal against papillomavirus by administering papillomavirus virus-like particles transdermally to a mammal under conditions effective to induce an immune response to the papillomavirus.

Abstract: A method and system for compressing video data in a computer has video processing that is distributed between preprocessing hardware in a video capture/controller card and a central processing unit of the computer. Frames of video data are passed to a motion estimation unit of the preprocessing hardware. This unit generates motion information describing inter-frame changes in the video data. Next, motion-compensated temporal filtering is performed on the frames of video data using the motion information. A video frame processing unit of the controller card, used for processing video data to the monitor, is reused for the temporal filtering of the input video data. Finally, the temporally-filtered video data is passed to the central processing unit, which performs inter-frame and/or intra-frame compression with reference to the motion information.

Abstract: The Fault Detection and Exclusion (FDE) system for use in navigational systems that rely upon multiple ranging signals, such as GPS satellites, uses an FDE algorithm to detect, as soon as possible, whether a fault exists in a signal associated with one or more of the GPS satellites. The system makes this determination by comparing a computed residual error with a first fault detection threshold. After determining that the computed residual error has exceeded the first, relatively low, fault detection threshold, the system transmits a signal to one or more external systems indicating that one or more signals associated with the various GPS satellites may be faulty. The system then monitors horizontal estimated position error (HUL) until this value has met or exceeded a relatively high fault isolation threshold value. The system then attempts to isolate and exclude the faulty satellite from the current navigational solution.

Abstract: The Fault Detection and Exclusion (FDE) system for use in navigational systems that rely upon multiple ranging signals, such as GPS satellites, uses an FDE algorithm to detect, as soon as possible, whether a fault exists in a signal associated with one or more of the GPS satellites. The system makes this determination by comparing a computed residual error with a first fault detection threshold. After determining that the computed residual error has exceeded the first, relatively low, fault detection threshold, the system transmits a signal to one or more external systems indicating that one or more signals associated with the various GPS satellites may be faulty. The system then monitors horizontal estimated position error (HUL) until this value has met or exceeded a relatively high fault isolation threshold value. The system then attempts to isolate and exclude the faulty satellite from the current navigational solution.

Abstract: The Fault Detection and Exclusion (FDE) system for use in navigational systems that rely upon multiple ranging signals, such as GPS satellites, uses an FDE algorithm to detect, as soon as possible, whether a fault exists in a signal associated with one or more of the GPS satellites. The system makes this determination by comparing a computed residual error with a first fault detection threshold. After determining that the computed residual error has exceeded the first, relatively low, fault detection threshold, the system transmits a signal to one or more external systems indicating that one or more signals associated with the various GPS satellites may be faulty. The system then monitors horizontal estimated position error (HUL) until this value has met or exceeded a relatively high fault isolation threshold value. The system then attempts to isolate and exclude the faulty satellite from the current navigational solution.

Abstract: A method and system for compressing video data in a computer has video processing that is distributed between preprocessing hardware in a video capture/controller card and a central processing unit of the computer. Frames of video data are passed to a motion estimation unit of the preprocessing hardware. This unit generates motion information describing inter-frame changes in the video data. Next, motion-compensated temporal filtering is performed on the frames of video data using the motion information. A video frame processing unit of the controller card, used for processing video data to the monitor, is reused for the temporal filtering of the input video data. Finally, the temporally-filtered video data is passed to the central processing unit, which performs inter-frame and/or intra-frame compression with reference to the motion information.

Abstract: A method and system for compressing video data in a computer has video processing that is distributed between preprocessing hardware in a video capture/controller card and a central processing unit of the computer. Frames of video data are passed to a motion estimation unit of the preprocessing hardware. This unit generates motion information describing inter-frame changes in the video data. Next, motion-compensated temporal filtering is performed on the frames of video data using the motion information. A video frame processing unit of the controller card, used for processing video data to the monitor, is reused for the temporal filtering of the input video data. Finally, the temporally-filtered video data is passed to the central processing unit, which performs inter-frame and/or intra-frame compression with reference to the motion information.