Patents by Inventor Robert Carl Spitale

Robert Carl Spitale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probes of RNA structure and methods for using the same
    Patent number: 9428791
    Abstract: Methods for obtaining structural data from RNA in a sample, and RNA probes for performing the same, are provided. Methods of reversibly modifying RNA is a sample, in vitro or in vivo, and reversible probes for performing the same, are provided. The RNA probes may be SHAPE probes that include aryl or heteroaryl acyl imidazoles. The RNA probes may be reversible probes that include an aryl or heteroaryl ring substituted with a hydroxyl-reactive group and an azido-containing group. Also provided are methods of comparing in vitro and in vivo RNA structural data. Also provided are methods of diagnosing a cellular proliferative disease condition, e.g., by probing HOTAIR RNA. Aspects of the invention further include compositions, e.g., probes and kits, etc., that find use in methods of the invention.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: August 30, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Robert Carl Spitale, Peter Joseph Crisalli, Howard Yuan-Hao Chang, Eric Todd Kool, Jong Hwa Jung
  • PROBES OF RNA STRUCTURE AND METHODS FOR USING THE SAME
    Publication number: 20140154673
    Abstract: Methods for obtaining structural data from RNA in a sample, and RNA probes for performing the same, are provided. Methods of reversibly modifying RNA is a sample, in vitro or in vivo, and reversible probes for performing the same, are provided. The RNA probes may be SHAPE probes that include aryl or heteroaryl acyl imidazoles. The RNA probes may be reversible probes that include an aryl or heteroaryl ring substituted with a hydroxyl-reactive group and an azido-containing group. Also provided are methods of comparing in vitro and in vivo RNA structural data. Also provided are methods of diagnosing a cellular proliferative disease condition, e.g., by probing HOTAIR RNA. Aspects of the invention further include compositions, e.g., probes and kits, etc., that find use in methods of the invention.
    Type: Application
    Filed: August 14, 2013
    Publication date: June 5, 2014
    Inventors: Robert Carl Spitale, Peter Joseph Crisalli, Howard Yuan-Hao Chang, Eric Todd Kool, Jong Hwa Jung