Abstract: Devices, and methods of use thereof, receivable by autosamplers for processing fluids contains suspended solids and solubles in, for example, solid phase extraction, include an inlet chamber in fluid communication with an outlet chamber through an integral fluid pathway. One or more autosampler needle(s) may inject the fluid into the inlet chamber, which contains a separation medium through which the injected fluid flows prior to flowing into the outlet chamber, from which fluid may be withdrawn by the autosampler needle(s). A pressure tight seal may be formed between the needle(s) and inlet chamber, and backflow is preventable from the outlet chamber to the inlet chamber. Numerous embodiments of the device are described, including well plate configurations and structures graspable by autosampler robotic devices and/or which may be held in autosampler trays.

Abstract: A device adapted to hold and compress a granular medium is disclosed. The device includes a body having an opening. A channel is positioned in fluid communication with the opening. A flexible substrate is attached to the body overlying the channel. The substrate and the channel cooperate to form a conduit in fluid communication with the opening. A compression member is mounted on the body. The compression member is engageable with the substrate. Engagement of the substrate by the compression member compresses the granular medium within the conduit. A plug blocks the opening and retains the granular medium within the conduit.