Abstract: The invention relates to a nucleic acid construct for delivery into living cells in vivo for inducing an immune response in a patient to an idiotypic determinant present on a malignant B cell in the patient; the construct directing the expression of a fusion protein, said fusion protein comprising the idiotypic determinant and at least one T helper cell epitope from tetanus toxin. The invention further relates to a method of making the nucleic acid construct, a method of treating a patient, and to a composition comprising the nucleic acid construct.

Abstract: We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.

Abstract: A negative-acting photoimageable composition comprisesA) between about 30 and about 90 wt % of a binder polymer which is soluble in an appropriate developer,B) between about 5 and about 30 wt % of an epoxy resin,C) between about 0 and about 30 wt % of a polyol cross-linking agent for the epoxy resin B), andD) between about 5 and about 15 wt % of a photosensitive composition of the formula: ##STR1## where the Zs are the samne or different and are selected from CX.sub.3, X, and H; the X's are the same or different halogens, and R is any chemical moiety consistant with the photoimageable composition as a whole.

Abstract: We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.

Abstract: A plastic packaging material which, when formed as a package having seams, will provide a predictable line of failure along a seam when the package is opened to prevent the package from tearing down the side. The predictable failure path is provided through a lamination process involving specific resins or blends of resins laminated in three (or more) layers in which an extruded inner layer forms a weak inner bond wholly within that inner layer to create the predictable line of failure and in which the process of forming the material does not inhibit processing speed, efficiency, and economics of materials used to provide this reliable openability.

Abstract: A photoresist composition comprising an alkali soluble resin, an o-naphthoquinone diazide sulfonic acid ester photoactive compound, and a vinyl ether compound. The o-naphthoquinone diazide sulfonic acid ester is replaced in part with the vinyl ether composition to decrease the concentration of the photoactive compound while increasing the photospeed of the composition.

Abstract: The invention provides radiation sensitive compositions that comprise an amphoteric polymer, the polymer comprising at least two distinct carrier groups so that the polymer is positively polarized or negatively polarized upon treatment with an acid or base, respectively, enabling the compositions to be electrodeposited either anaphoretically or cataphoretically. Employing this amphoteric polymer in a radiation sensitive composition also allows the use of either an acid or base solution to image and remove the deposited composition irrespective of whether the composition was applied cataphoretically or anaphoretically. The compositions of the invention are also suitably formulated as liquid coating compositions or used to form dry film resists.

Abstract: The disclosed invention relates to a method of manufacturing hybrid circuit boards which uses the step of electrodeposition of a photoresist composition onto said boards. This step represents improvements in the prior art use of dry film or other types of photoresists which did not conform to all three dimensional surfaces and which were not aqueous developable.

Abstract: This invention provides a means of controlling the composition of electrodepositable photoresists emulsion. The system removes contaminants from the bath which may adversely effect the quality of the deposited coatings and allows for continuous monitoring of the conductivity of the system.

Abstract: A process for manufacturing a 3-dimensional circuit board by electrophoretic deposition whereby (a) providing the board with a conductive surface and (b) applying a photoresist by electrophoretic deposition.

Abstract: A power-actuated fastener tool for the driving of a fastener object into hard material such as concrete or metal, the tool being of a type having a relatively movable barrel and housing components, the barrel carrying a power load chamber body and a relatively movable piston member which in muzzleward movement drives the fastener object, and on breechward movement achieves ejection of the spent power load cartridge; and the housing carries a movable firing pin assembly. The housing is provided with an offset axially-extending wall, and its opposite ends serve as abutments co-opereative with a transverse pin, carried by the piston and extending through a slot in the barrel wall, to achieve various operative features.

Abstract: A patient tracking system is employed to determine when an occupant leaves the confines of a nursing home or similar institution. Each patient has a transmitter strapped to his or her wrist which emits a signal having a distinctive radio frequency. The corridors of the nursing home include a plurality of sharp receiving antenna elements connected together in series by a coaxial cable. A scanning radio receiver is attached to the antenna system. The scanning radio receiver determines when the strength of the signal received by the antenna elements falls below a predetermined level at which point an alarm is sounded. If the alarm sounds, an attendant uses a second, directional receiver to track the patient who may have wandered away before the patient hurts himself or herself.

Abstract: A method for coating a conductive surface with an organic coating where one discrete area of the organic coating is coated onto the surface in an image pattern by conventional means and another discrete area of the organic coating is electrophoretically deposited onto the surface. The process is useful for diverse applications including the fabrication of printed circuit boards.

Abstract: The tool has a reciprocating barrel mounted in a housing and includes a ram mounted in the barrel for driving a fastener into a work surface. The firing mechanism has a firing pin and a firing pin driver which the operator strikes with a hammer to fire a cartridge chambered in the tool. The firing pin driver is biased to a retracted safe position when the tool is not cocked so as to prevent drop fire. A detent pawl is mounted on the ram to provide frictional retention forces for the ram and barrel. The pawl cooperates with a resilient stop mounted on the housing to return the ram from a driven position to a driving position when the barrel is reciprocated in the housing, and the pawl also engages a breechward stop formed in the housing which prevents the ram from contacting a chambered cartridge when the tool is in a breech-closed, ready-to-fire condition. Bellville washer stacks are used to position the firing mechanism. An improved hand grip is also provided.