Patents by Inventor Robert E. London

Robert E. London has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent magnesium indicators
    Patent number: 6706528
    Abstract: The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: March 16, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert E. London, Pieter Otten, Louis A. Levy
  • Fluorescent magnesium indicators
    Publication number: 20020031834
    Abstract: The present invention generally relates to analytical elements and methods for the selective determination of magnesium. In particular, the present invention is further directed to carboxy-quinolizine suitable for use as magnesium indicators, and more particularly, to 4-oxo-4H-quinolizine-3-carboxylic acid derivatives for use as novel fluorescent magnesium indicators.
    Type: Application
    Filed: March 23, 2001
    Publication date: March 14, 2002
    Applicant: The Government of the United States
    Inventors: Robert E. London, Pieter Otten, Louis A. Levy
  • Fluorescent and NMR sensitive pH indicators
    Patent number: 5639906
    Abstract: This invention relates to compositions and methods useful for measuring pH generally, and intracellular pH specifically, and, more particularly, to a new class of fluorescent and fluorinated (NMR sensitive) aromatic compounds having excitation emission wavelengths in the ultraviolet or or visible portions of the electromagnetic spectrum, useful as pH indicators, as well as fluorine containing analogs useful in NMR spectroscopic determinations.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: June 17, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert E. London, Louis A. Levy, Chung K. Rhee
  • Fluorescent intracellular calcium indicators
    Patent number: 5516911
    Abstract: A new class of calcium-specific, NMR-active and/or fluorescent indicators having a high dissociation constant is described. Methods of determining intracellular calcium ion concentration using .sup.19 F NMR spectroscopy or optical methods are also provided.
    Type: Grant
    Filed: December 30, 1993
    Date of Patent: May 14, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Robert E. London, Louis A. Levy, Elizabeth Murphy