Abstract: One aspect is a method of forming a lead for implantation. The method includes forming a distal end assembly, forming a proximal end assembly, and forming a flexible circuit coupling the distal end assembly to the proximal end assembly. The distal end assembly, the proximal end assembly and the flexible circuit are formed over an inner member. An outer member is placed over the combination of the distal end assembly, the proximal end assembly and the flexible circuit. The outer member and circuit are fused adjacent the distal end assembly to the proximal end assembly.

Abstract: The present invention provides for methods, processes and platforms to validate systems genetics networks to define their genetic regulators and to optimize translational applicability to humans for drug development. These systems genetics networks are sets of genes with a common function that demonstrate covariate expression that is genetically modulated by linked function network regulators (LFNRs) which comprise eQTLs in animals and GWAS SNPs in humans. LFNRs represent a new class of targets to identify drugs to prevent, ameliorate, and/or treat human diseases. LFNRs for the cell cycle-mitosis network have potential to be especially useful for anti-cancer therapies. The present invention provides for a drug that targets a specific LFNR for the cell cycle-mitosis network in Caucasian male liver to prevent the development of hepatocellular carcinoma in high risk patient populations.

Abstract: Fish lure includes a flexible body having a forward body having maximum width and weight tapering to an aft body having reduced width and height; and a swimming tail portion flexibly connected to the aft body, wherein the swimming tail is flared, wherein the tail increases in width and height toward a tail tip as compared with the aft body portion, and a central channel groove generally parallel to a long axis of the lure, the long axis being normal to both width and height of the lure, the channel groove extending to the tail tip and maintaining a smaller width dimension as compared to adjacent flared portions of the tail, wherein water flow across the tail is guided through the channel groove and across the flared portions of the tail to provide vertically-balanced water flow across the tail and to produce a uniform horizontal swimming movement of the tail.

Abstract: A wall construction system includes a footer attached to a floor or footer; vertical reinforcing bars attached to the footer; horizontal reinforcing bars attached to vertical reinforcing bars at predetermined heights above the footer; blocks attached onto the footer, each layer including a row of blocks, each block including a pair of flat major surfaces and four contoured minor surfaces, and a plurality of longitudinal grooves parallel to the major surfaces and incorporated into the edges of the minor surfaces; a plurality of joining strips, the strips placed end to end and pressed into each longitudinal groove, with about half their width protruding from the longitudinal grooves; a plurality of lateral clips attached to pairs of joining strips across the top of the blocks, perpendicular to the longitudinal grooves; and a quantity of concrete in horizontal and vertical air gaps between adjacent blocks enveloping horizontal and vertical reinforcing bars.

Abstract: A non-symmetrical half-duplex data communications apparatus and method provides for transmitting and receiving non-symmetrical half-duplex signals over a communications link. The non-symmetrical half-duplex data communications apparatus includes interface circuitry that is connectable to the communications link and modulation circuitry to transmit and receive the non-symmetrical half-duplex signals over the communications link. The modulation circuitry of the non-symmetrical half-duplex data communications apparatus includes the ability to transmit data signals with a transmission time that is different than the transmission time of receive signals. The modulation circuitry of the non-symmetrical half-duplex data communications apparatus also includes the ability to transmit data signals with a transmission data rate different than the transmission data rate of receive signals.

Abstract: An improved system and method for transporting ATM information over a communications channel by enabling a single 4-octet ATM header to be prepended to user data, thus forming a low overhead ATM cell. Furthermore, an alternative embodiment of the invention may be used to simultaneously transport a plurality of 52 octet ATM frames in conjunction with the low overhead cells.

Abstract: Embodiments of the present invention provide communication of Asynchronous Transfer Mode (ATM) data using variable duration ATM frames between a data terminal unit (DTU) at a central office and a remote DTU at a user premises. One embodiment of the present invention can be viewed as a communication device which communicates data in an asynchronous transfer mode (ATM) format, the device comprising at least one buffer configured to receive data from a sending device, and a modulation unit coupled to the buffer and configured to encapsulate a plurality of ATM cells into an ATM frame, the plurality of ATM cells having the received data, so that the ATM frame is communicated onto a subscriber line, such that the communicated ATM frame has a variable transmission duration, the variable transmission duration corresponding to a number of the plurality of ATM cells encapsulated into the ATM frame.

Abstract: Apparatus and method for a central office data communications apparatus allows for combining the voice POTS and high speed modem data processing functions into one device at the central office. The combination of the signals allows for a single high-speed CODEC which samples both a POTS signal and the high-speed modem signals to be utilized. This eliminates the need for external POTS splitters and costly duplicative circuitry.

Abstract: Terminal differentiation is associated with repression in the expression of the P2P subset of hnRNP proteins. The present invention provides a P2P cDNA that encodes proteins with domains for hnRNP association and Rb1 binding. Probes to the P2P cDNA detect a single 8 kb mRNA in multiple murine tissues, in proliferating murine 3T3 cells but not in terminally differentiated 3T3T adipocytes. The interaction of P2P cDNA products and Rb1 may serve to modulate cell proliferation and/or other biological functions associated with tumor suppression by an RNA processing mechanism. Moreover, it was shown that P2P antisense oligonucleotides selectively repressed 30-40 kDa P2P expression.

Abstract: An inflator (10) comprises a housing (20) defining first and second combustion chambers (100, 120). A first inflation fluid source (140) in the first combustion chamber (100) is actuatable to effect flow of inflation fluid. A first initiator (112) in the housing (20), when energized, effects actuation of the first inflation fluid source (140). A second inflation fluid source (150) in the second combustion chamber (120) is actuatable to effect flow of inflation fluid. A second initiator (124) in the housing (20), when energized, effects actuation of the second inflation fluid source (150). The housing (20) deforms due to the pressure of inflation fluid in the housing upon actuation of one or both of the inflation fluid sources (140, 150). The housing (20), after deforming, has a fluid passage (90) for directing flow of inflation fluid out of the housing. The flow area of the fluid passage (90) varies in accordance with the pressure of inflation fluid in the housing (20).

Abstract: Terminal differentiation is associated with repression in the expression of the P2P subset of hnRNP proteins. The 5173 base pair P2P cDNA was cloned and characterized. The cDNA contains a 4214 base pair open reading frame. Probes to the P2P cDNA detect a single 8 kb mRNA in multiple murine tissues, in proliferating murine 3T3T cells but not in terminally differentiated 3T3T adipocytes. Evidence that the P2P cDNA can encode proteins with domains for hnRNP association was established by showing that the C130 monoclonal antibody, produced against a fusion protein derived from the P2P cDNA, selectively detects native P2P hnRNP proteins. In addition, it was shown that P2P antisense oligonucleotides selectively repressed 30-40 kDa P2P expression. Since terminal differentiation is also associated with modulation in Rb1 function, assays were performed which demonstrated that P2P cDNA products interact with Rb1.

Abstract: An inflator (10) comprises a housing (20) defining first and second combustion chambers (100, 120). A first inflation fluid source (140) in the first combustion chamber (100) is actuatable to effect flow of inflation fluid. A first initiator (12) in the housing (20), when energized, effects actuation of the first inflation fluid source (140). A second inflation fluid source (150) in the second combustion chamber (120) is actuatable to effect flow of inflation fluid. A second initiator (124) in the housing (20), when energized, effects actuation of the second inflation fluid source (150). The housing (20) deforms due to the pressure of inflation fluid in the housing upon actuation of one or both of the inflation fluid sources (140, 150). The housing (20), after deforming, has a fluid passage (90) for directing flow of inflation fluid out of the housing. The flow area of the fluid passage (90) varies in accordance with the pressure of inflation fluid in the housing (20).

Abstract: An echo canceler disabling system is associated with a cellular data communications device, such as a modem, which is utilized to communicate digital data over a cellular network for the purpose of enhancing digital data communications over the network. The echo canceler disabling system is configured to disable voice echo cancelers brought on-line during digital data transmission after call startup in order to prevent disruption of digital data communications by the voice echo cancelers. To deactivate the voice echo cancelers, the echo canceler disabling system is configured to transmit a tone at approximately 2100 Hz with 180 degree phase reversals to disable one or more echo cancelers brought on-line after the call startup.

Abstract: A modem apparatus and method to allow a single central site modem with a low processing power DSP to handle numerous DSL lines. More particularly, the modem apparatus and method take advantage of the bursty nature of Internet data traffic to allow the low processing power DSP equipped modem to handle multiple lines simultaneously. The multiple lines can be serviced via a round robin routine or via a quality of service routine, in which the data traffic on the line is analyzed for real time activity, such analysis using UDP transport layer protocol to determine real time activity. The quality of service routine also constantly monitors the data communications lines during periods of data communication to determine if a data line should be entered into the high priority queue.

Abstract: An inflator (10) comprises a housing (20) defining a combustion chamber (144). An inflation fluid source (152) in the combustion chamber (144) in the housing (20) is actuatable to provide inflation fluid under pressure. An initiator (94) is provided in the housing (20) for actuating the inflation fluid source (152). The housing (20) has a fluid passage (150) for directing flow of inflation fluid out of the housing. The housing (20) deforms due to the pressure of inflation fluid in the housing upon actuation of the inflation fluid source (152) by the initiator (94). The flow area of the fluid passage (150) increases due to deformation of the housing (20) and varies in accordance with the pressure of inflation fluid in the housing upon actuation of the inflation fluid source (152).

Abstract: The strength of a local echo signal is used to dynamically adjust the transmit signal level of a modem. In particular, the modem provides a transmit signal to a local loop of a public switched telephone network (PSTN). This local loop couples the modem to, for example, a central office. The amount of reflected energy from the central office, i.e., echo, received by the modem is inversely proportional to the amount of energy actually getting through to the central office. If the magnitude of the local echo signal is small, which indicates that most of the transmit signal energy is reaching the equipment of the central office, then the signal level of the transmit signal is lowered. Conversely, if the magnitude of the local echo signal is large, which indicates that most of the transmit signal energy is being back reflected from the central office, then the signal level of the transmit signal is raised.

Abstract: The specification describes a process for pelletising particles of an alkali metal ferrite with an aqueous binder such as a black liquor derived from pulping wood chips. The particles are ground and fed to a microgranulator in measured quantities together with measured quantities of aqueous binder. The particles are ground such that they have an even size distribution about a mean in the range from 25 to 50 microns. The particles are mixed with the binder in the microgranulator to form microgranules which are fed to a pelletising pan. The temperature of the microgranules on the pelletising pan is controlled by cooling either or both the alkali metal ferrite or aqueous binder prior to measuring them into the microgranulator. A pan temperature of less than 70.degree. C. is disclosed.

Abstract: The specification describes a process for recovering alkali metal hydroxides from an organic liquor such as black liquors derived from pulping wood chips. The organic liquor is burned in a fluidised bed combustion furnace containing fluidised particles of an iron rich mixed oxide of an alkali metal and iron. Particles of alkali metal ferrite are extracted from the furnace and dissolved in a solution of alkali metal hydroxide to form a more concentrated solution of alkali metal hydroxide and a precipitate of the iron rich mixed oxides of alkali metal and iron. A mixed oxide disclosed in the specification generally has the following formula: NaFe.sub.5 O.sub.8.4H.sub.2 O.

Abstract: In transmitting information over a cellular communications channel to an opposite endpoint, a modem's autorating routine is "data-driven." In particular, when the amount of information to transmit to the opposite endpoint is low, the modem's data rate is low e.g., 4800 bps, and the modem's ability to autorate upwards, i.e., fallforward, is disabled. However, when the amount of information to transmit to the opposite endpoint is high the modem's ability to fallforward is enabled so that the modem's data rate can increase to the highest permissible data rate for the cellular channel in order to transmit large blocks of information.