Abstract: Provided herein are methods and compositions for suppressing or preventing an infection in a subject infected by a pathogen or decreasing organ or tumor tissue fibrosis that involve administering to the subject a composition that includes a therapeutically effective amount of a p53 therapy. Also disclosed are methods of suppressing tumor stroma by contacting the tumor stroma with the p53 therapy, wherein the p53 suppresses tumor stroma activities.

Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of an adenoviral vector with a genetically modified fiber incorporating a Lyp-1 peptide motif and at least one CD122/CD132 agonist and/or an immune checkpoint inhibitor.

Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one CD 122/CD 132 agonist, at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to overexpress a tumor suppressor gene and/or an adenoviral death protein. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one oncolytic viral composition and at least one CD122/CD132 agonist and at least one immune checkpoint inhibitor. Also provided herein are methods of enhancing anti-tumor efficacy by administering the agents described above in combination with other cancer therapies. In highly aggressive forms of cancer, known to be generally resistant to immune therapies, these treatments unexpectedly resulted in complete tumor remissions and curative outcomes.

Abstract: The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.

Abstract: The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.

Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a viral composition comprising one or more viruses engineered to comprise an N1L gene deletion, a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of a viral composition comprising two or more viruses engineered to comprise an N1L gene deletion a matrix-degrading protein gene, an adenoviral death protein (ADP) gene, and/or a cytochrome p450 gene. Also provided herein are methods of enhancing antitumor efficacy by administering the agents described above in combination with other cancer therapies.

Abstract: Provided herein are methods and compositions for treating cancer in an individual comprising administering to the individual an effective amount of at least one immune checkpoint inhibitor and a p53 and/or MDA-7 (IL24) gene therapy. Also provided herein are methods of enhancing anti-tumor efficacy by administering an extracellular matrix-degrading protein. Also provided herein are methods of enhancing anti-tumor efficacy by administering metronomic chemotherapy (for agents described above, 5FU+CTX+GM-CSF) in combination with a p53 and/or IL24 gene therapy.

Abstract: The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.

Abstract: The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.

Abstract: Multiple uncompressed digital images, each at a different exposure, may be captured automatically in response to an image capture request. The set of uncompressed digital images may be stored as a single data object and manipulated to produce a final digital image.

Abstract: An electronic image capture device including an image capture array, an optional image stabilization gyro, a processor, and a display is configured to detect the amount shaking of the device either prior to, or during image capture. When the shaking of the device exceeds a threshold required for the capture of quality images, the user of the image capture device is notified through the display that excessive shake has been detected and may be advised on methods to reduce or eliminate the shake.

Abstract: The present invention relates to the identification of p53 biomarker profiles that predict response in patients with hyperproliferative disease such as cancer to a therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy.

Abstract: Reducing or eliminated color-dependent vignetting in a digital camera includes: providing a raw array of data corresponding to an image of a scene for each color that the camera can image; and adjusting the raw arrays such that the array for each color exhibits substantially the same amount of vignetting.

Abstract: Digital imaging systems, articles of manufacture, and digital image processing methods are described. According to one aspect, a digital imaging system includes an imaging system configured to provide image data of an image, the image data comprising digital image data for a plurality of pixel locations and processing circuitry configured to process the image data provided by the imaging system to denoise and sharpen the image data, wherein the processing circuitry, for an individual one of the pixel locations, is configured to identify a respective subset of the image data corresponding to the one pixel location and perform a single processing operation using the image data of the identified subset of the image data to denoise and sharpen the image data of the individual one pixel location.

Abstract: Digital image processing methods, digital image devices and articles of manufacture are described. According to one aspect, a digital image processing method includes providing digital image data of a plurality of colors of an image, wherein the image data comprises a plurality of sets individually comprising mosaic data of one of a plurality of colors at a plurality of pixel locations, analyzing image data of one of the pixel locations with respect to image data of another of the pixel locations, and adjusting the image data of the one pixel location responsive to the analyzing, wherein the adjusting comprises adjusting to one of denoise the image data and sharpen the image data.

Abstract: A digital imaging device detects or tracks a user's direction of gaze. The detected direction of gaze may be used to set one or more functions in the digital imaging device, and the history of the user's direction of gaze may be stored with a captured digital image for later use by an automatic image post-processing apparatus.

Abstract: Reducing or eliminated color-dependent vignetting in a digital camera includes: providing, for each color that said camera can image, a raw array of data corresponding to a desired scene; and changing the raw arrays such that the array for each color exhibits substantially the same amount of vignetting so as to reduce color-dependent vignetting in a composite image based upon each of the changed arrays.

Abstract: Disclosed are systems and methods for providing spatially-varied demosaicing. In one embodiment, a system and method pertain to collecting color information sensed by image sensor pixels, and estimating color information as to a pixel under consideration that is not collected by the pixel by weighting color information collected by adjacent pixels that are positioned in a direction in which color is shifted due to lateral chromatic aberration.

Abstract: A digital camera and method that embodies a preview image that shows what the final image will look like, including depth of field and shutter speed temporal effects (blur). Preview images are displayed as a series of stop-action still images rather than as continuous video. Overlays or picture-in picture can be used to show live action video simultaneously for framing.

Abstract: A method of local contrast mapping that changes the dynamic range of an original image to more closely match the dynamic range of the medium used for the reproduction. The method compresses large contrast differences between different areas of an image while preserving small contrast differences between different areas of an image.