Abstract: A guard for a hypodermic syringe needle which keeps the extremities and particularly the hands well away from the syringe to prevent accidental punctures with contaminated needles. The needle guard is in the form of a cylindrical cap which slides over the needle having a manipulating device to remove and replace the guard while keeping the hands well away from the needle. In one embodiment the manipulating device is in the form of a flexible handle having a resilient clamping flanges which clamp the device around the barrel of the syringe. The extension has a webbed hinge allowing it to easily flex outward away from the syringe needle for removal or replacement of the end cap. Alternately the end cap may be hingedly attached to a collar slideable on the syringe barrel by which the cap can be slid downward to remove the cap and retracted to replace the cap.