Patents by Inventor Robert G. Pergolizzi

Robert G. Pergolizzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analyte detection utilizing polynucleotide sequences, composition, process and kit
    Patent number: 9134302
    Abstract: A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 15, 2015
    Assignee: Enzo Diagnostics, Inc.
    Inventors: Robert G. Pergolizzi, Jannis G. Stavrianopoulos, Elazar Rabbani, Dean L. Engelhardt, Stan Kline, Paula J. Olsiewski
  • Methods for predicting increase sperm ejaculate in a varicocele associated fertility patient
    Patent number: 7413861
    Abstract: The present invention provides a method for predicting whether a patient having varicocele-associated infertility will have an increase in sperm in the ejaculate after varicocele repair surgery. In the method of the present invention, the present or absence of undelete forms of exons 6, 7, 8 and 9 the patient's L-VDCC ?1c transcript is detected. The presence of undeleted forms of the exons indicates that varicocele repair surgery will result in increased ejaculate, and the absence of undeleted forms of the exons indicates that varicocele repair surgery will not result in increased ejaculate.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: August 19, 2008
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Susan Benoff, Ian R. Hurley, Robert G. Pergolizzi, Leslie Goodwin
  • Oligonucleotides for detecting male infertility
    Patent number: 6833244
    Abstract: The present invention provides a method, oligonucleotide probes and primers, and assay kits for diagnosing an individual as having hypospermatogenesis associated infertility that involves demonstrating in the individual the presence or absence of a variant form of a gene in exons 6, 7, 8 or 9 of the L-VDCC &agr;1c transcript.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: December 21, 2004
    Assignee: North Shore - Long Island Jewish Research Institute
    Inventors: Susan Benoff, Ian R. Hurley, Robert G. Pergolizzi, Leslie Goodwin
  • Method and kits for detection of fragile X specific, GC-rich DNA sequences
    Patent number: 6200747
    Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: March 13, 2001
    Assignee: North Shore University Hospital Research Corp.
    Inventors: Robert G. Pergolizzi, Susan H. Erster, W. Ted Brown
  • Method and kits for detection of fragile X specific, GC-rich DNA sequences
    Patent number: 5658764
    Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: North Shore University Hospital Research Corp.
    Inventors: Robert G. Pergolizzi, Susan H. Erster, W. Ted Brown