Patents by Inventor Robert G. Strachan

Robert G. Strachan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic octapeptide analogs of neurotensin
    Patent number: 4439359
    Abstract: There are disclosed cyclic octapeptide analogs of the tridecapeptide, neurotensin.
    Type: Grant
    Filed: July 2, 1982
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Frederick W. Holly, deceased, Marcia E. Christy, Kenneth L. Shepard, Robert G. Strachan, Sandor L. Varga, Daniel F. Veber
  • Metabolically protected analogs of neurotensin
    Patent number: 4425269
    Abstract: There are disclosed metabolically protected linear analogs of the carboxy terminal pentapeptide fragment of the tridecapeptide, neurotensin.
    Type: Grant
    Filed: June 7, 1982
    Date of Patent: January 10, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Marcia E. Christy, Kenneth L. Shepard, Robert G. Strachan, Sandor L. Varga
  • Somatostatin analogs
    Patent number: 4162248
    Abstract: Somatostatin analogs having the structural formula:Cyclo[(X).sub.j -(A).sub.k -(B).sub.1 -Phe-Phe-(D- or L-)Trp-Lys-Thr-Phe-Thr-(C).sub.m ]WhereinX is ##STR1## and n=0 to 4; A is Lys, (.epsilon.-INOC) Lysine;B is Asn, Ala, .alpha.-aminobutyric acid;C is Ser, Gly;J, k, l and m are 0 to 1; with the proviso that j, k, l, and m are not all 1 and not all 0,Wherein the ring formed by the peptide backbone contains 24 to 33 atoms and the pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, decreasing gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert G. Strachan, William J. Paleveda, Daniel F. Veber, Frederick W. Holly
  • Somatostatin analogs
    Patent number: 4161521
    Abstract: Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: July 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Frederick W. Holly, Robert G. Strachan, William J. Paleveda, Ruth F. Nutt, Ralph F. Hirschmann
  • Process for preparing somatostatin analog
    Patent number: 4130554
    Abstract: Somatostatin analog, hereinafter designated des(Ala.sup.1 -Gly.sup.2)desaminocys.sup.3 -somatostatin, having the structure: ##STR1## is prepared by controlled stepwise procedures starting with individual amino acid components. This peptide has the property of lowering blood glucose, inhibiting gastric secretion and inhibiting growth hormone release in humans and animals.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: December 19, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Frederick W. Holly, William J. Paleveda, Robert G. Strachan, Daniel F. Veber
  • Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
    Patent number: 4098777
    Abstract: This invention is directed to the chemical process for the preparation of the polypeptide, pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn and to intermediates in said process. The polypeptide prepared by the present process is useful in the treatment of autoimmune diseases such as Lupus like pathology and specifically for the treatment of Lupus Erythematosus in man. This polypeptide is also useful for selectively stimulating T-cell activity in aging subjects.
    Type: Grant
    Filed: March 14, 1977
    Date of Patent: July 4, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Robert G. Strachan