Patents by Inventor Robert Gale
Robert Gale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220017482Abstract: Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium or treating or preventing a bacterial infection.Type: ApplicationFiled: November 20, 2019Publication date: January 20, 2022Inventors: Eric Brown, Omar M Elhalfawy, Maya Farha, Jakob Magolan, Robert Gale
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Publication number: 20200101134Abstract: Provided herein are methods for treating myeloproliferative neoplasm-associated myelofibrosis in a subject, comprising administering to the subject an ActRIIB signaling inhibitor. Also provided herein are methods for treating myeloproliferative neoplasm-associated myelofibrosis in a subject in need thereof, wherein the method comprises administering to the subject a pharmaceutically effective amount of an ActRIIB signaling inhibitor, and wherein said treating reduces or palliates one or more symptoms of said myeloproliferative neoplasm-associated myelofibrosis in said subject. Also provided herein is a method for treating anemia in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of an ActRIIB signaling inhibitor, wherein the subject has myeloproliferative neoplasm-associated myelofibrosis.Type: ApplicationFiled: June 13, 2018Publication date: April 2, 2020Inventors: Abderrahmane Laadem, Robert Gale
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Patent number: 8915168Abstract: A socket for driving a threaded fastener into a material has teeth spaced around a fastener opening. The teeth cut out a counterbore hole that receives the head of the fastener as the fastener threads into the material.Type: GrantFiled: September 12, 2011Date of Patent: December 23, 2014Inventor: Robert Gale Jeter, Jr.
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Patent number: 8870808Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: GrantFiled: December 23, 2011Date of Patent: October 28, 2014Assignee: E2, LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Patent number: 8579849Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: GrantFiled: February 1, 2012Date of Patent: November 12, 2013Assignee: E2 LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Publication number: 20130061400Abstract: A socket for driving a threaded fastener into a material has teeth spaced around a fastener opening. The teeth cut out a counterbore hole that receives the head of the fastener as the fastener threads into the material.Type: ApplicationFiled: September 12, 2011Publication date: March 14, 2013Inventor: Robert Gale Jeter, JR.
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Publication number: 20130006381Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: ApplicationFiled: December 23, 2011Publication date: January 3, 2013Applicant: E2 LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Publication number: 20120136457Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: ApplicationFiled: February 1, 2012Publication date: May 31, 2012Applicant: E2 LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Patent number: 8182442Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: GrantFiled: April 9, 2009Date of Patent: May 22, 2012Assignee: ElectroCore LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Patent number: 8142385Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: GrantFiled: April 9, 2009Date of Patent: March 27, 2012Assignee: E2 LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Patent number: 8100850Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: GrantFiled: April 9, 2009Date of Patent: January 24, 2012Assignee: E2 LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Publication number: 20090259239Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: ApplicationFiled: April 9, 2009Publication date: October 15, 2009Applicant: Stryker Development LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Publication number: 20090259237Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: ApplicationFiled: April 9, 2009Publication date: October 15, 2009Applicant: Stryker Development LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Publication number: 20090259238Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.Type: ApplicationFiled: April 9, 2009Publication date: October 15, 2009Applicant: Stryker Development LLCInventors: Buket Grau, David Robert Gale, Sam Anne Musgrave, George McGee Perkins, Mark Jeffrey Edhouse, Marc Graham, Christopher Kadamus
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Patent number: 7553296Abstract: A medical safety device is provided and includes a needle hub having a needle supported thereon; and a safety shield operatively mounted on the needle hub. The safety shield includes a pair of spaced legs and a foot member. Each proximal segment includes a camming surface. The safety shield further includes a trigger supported on the foot member. The trigger includes a camming member and is movable to move the camming member into engagement with the camming surfaces of the proximal segments to effect movement of the legs from a first position in which the distal ends of the distal segments shield a distal end of the needle to a second position in which the distal end of the needle is at least partially exposed. The trigger is removably secured to the foot member.Type: GrantFiled: August 22, 2007Date of Patent: June 30, 2009Assignee: Tyco Healthcare Group LPInventors: Anthony Jonathan Bedford, David Robert Gale, Robin Craig Cocker, Adrian Edward Cooper
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Publication number: 20080031933Abstract: A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.Type: ApplicationFiled: August 20, 2007Publication date: February 7, 2008Inventor: Robert Gale
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Publication number: 20080009782Abstract: Electrotransport drug delivery devices, systems and methods for delivery of lofentanil or carfentanil are disclosed. The lofentanil or carfentanil may be provided as a water soluble salt (e.g., lofentanil or carfentanil hydrochloride), such as in a hydrogel formulation. A transdermal, electrotransport delivered dose of lofentanil or carfentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from chronic, acute and/or breakthrough pain.Type: ApplicationFiled: June 26, 2007Publication date: January 10, 2008Applicant: ALZA CorporationInventors: Robert Gale, Rama Padmanabhan, Joseph Phipps
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Publication number: 20070278251Abstract: A dispensing apparatus (1) including a combination of a tube (2), cap (4) and plunger (3). The tube is arranged for carrying a collapsible sausage (6) and includes longitudinally extending ribs (8) projecting inwardly of the tube and defining longitudinal grooves (7) therebetween, the grooves having an annular dimension (A) greater than the distance (B) between adjacent ribs. The cap includes: a coupling portion (20) for mounting the cap to the tube; an outlet (21) through which contents of the collapsible sausage carried within the tube arc dispensed; and a chamber (22) into which the sausage is adapted to be collapsed under action of the plunger within the tube. The plunger itself has a main body (11) with radial fins (10) projecting therefrom for receipt in the grooves of the tube, between adjacent ribs, the fins being dimensioned to engage lateral edges of the ribs, in a point contact manner.Type: ApplicationFiled: December 21, 2001Publication date: December 6, 2007Inventors: Angelo Guerrera, Robert Gale, Mahmound Chemait
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Patent number: 7300423Abstract: A safety device, usable in particular with hypodermic needles, and incorporating a trigger mechanism which when activated primes the device to initiate the unsheathing of the needle in use by flexing one or more needle-surrounding legs away from the needle axis; the initial priming and leg-flexing movement being caused by the interaction of an operative portion of the trigger with the or each said leg or with a member connected operatively thereto; characterised by the feature that, when such movement occurs, the trigger end interacts with the leg or the said, part connected thereto in a manner which positively latches and retains the two in engagement.Type: GrantFiled: November 19, 2003Date of Patent: November 27, 2007Assignee: Tyco Healthcare Group LPInventors: Robin Craig Cocker, Anthony Jonathan Bedford, David Robert Gale
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Publication number: 20070134310Abstract: A system for transdermal delivery of risperidone to an individual. The system has a high risperidone loading with suitable permeation enhancers to effect therapeutic flux rate. Acrylate polymeric reservoir with the high risperidone and permeation enhancers dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.Type: ApplicationFiled: September 22, 2006Publication date: June 14, 2007Inventors: Diane Nedberge, Robert Gale, Nieves Crisologo, Jianye Wen, Delphine Imbert, Allison Luciano, Eric Silverberg, Paul Foreman, Johan Geerke