Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom of the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.

Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom of the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.

Abstract: A filtration device is disclosed for filtering debris from a biofluid sample. In at least one embodiment, the filtration device provides a collection container having a collection chamber defined by a flexible wall, a mouth fluidly communicating with the collection chamber and formed through the collection container at a top end, and a filter device defining a bottom to the collection chamber. A quantitative container has a quantitative chamber in fluid communication with the filter device with the filter device separating the collection chamber from the quantitative chamber. A biofluid sample is introduced into the collection chamber through the mouth, and when the mouth with a collection chamber cap, the flexible wall of the collection container is squeezed to reduce the volume of the collection chamber and force the biofluid sample through the filter device, the filtered biofluid sample thereafter being contained within the quantitative chamber.

Abstract: The present specification discloses filtration devices for processing a biofluid sample, methods of purifying a biofluid sample using the disclosed filtration devices, and systems comprising components of the filtration devices. The filtration device generally includes a collection container, a quantitative container, a filter, and a plunger slidably inserted through a plunger attachment. In a first configuration, the quantitative container is axially slidably inserted within the collection chamber, with fluid communication between the quantitative chamber and the collection chamber provided through the filter. In a second configuration, the filter and the collection container are separated from the quantitative container, the plunger attachment is fitted to the quantitative chamber open end with at least a portion of the plunger positioned within the quantitative chamber.

Abstract: The present specification discloses filtration devices for processing a biofluid sample, methods of purifying a biofluid sample using the disclosed filtration devices, and systems comprising components of the filtration devices.

Abstract: According to the present invention, a fluid and/or aqueous additive delivery system is provided. According to the present invention, a modular fluid container is described for consumption of liquids. Fluid containers according to the present invention include any combination of four distinct modular components; (1) an end-point filter purification module for removal of impurities from water, (2) a UV purification module for emitting ultraviolet (UV) light in a germicidal spectrum for disinfection, (3) a tablet storage and dispensing module to emit ultraviolet (UV) light in a germicidal spectrum for disinfection of a volume of drink liquid held in the container, (4) a flow meter module for quantitatively monitoring hydration in real time. The user can personalize the bottle with any or all modules that are required.

Abstract: The present specification discloses filtration devices for processing a biofluid sample, methods of purifying a biofluid sample using the disclosed filtration devices, and systems comprising components of the filtration devices.

Abstract: According to the present invention, a fluid and/or aqueous additive delivery system is provided. According to the present invention, a modular fluid container is described for consumption of liquids. Fluid containers according to the present invention include any combination of four distinct modular components; (1) an end-point filter purification module for removal of impurities from water, (2) a UV purification module for emitting ultraviolet (UV) light in a germicidal spectrum for disinfection, (3) a tablet storage and dispensing module to emit ultraviolet (UV) light in a germicidal spectrum for disinfection of a volume of drink liquid held in the container, (4) a flow meter module for quantitatively monitoring hydration in real time. The user can personalize the bottle with any or all modules that are required.

Abstract: Embodiments of the present invention are directed to sensitive, specific, and commercially feasible assays for transferase activity. Various embodiments of the present invention include artificial, multifunctional substrates specific for particular transferases that are chemically altered by the transferases to produce easily detectable, modified, multifunctional substrates. In one class of embodiments, the artificial, multifunctional substrate comprises a small-molecule-substrate component, or small-molecule-substrate-analog component, linked by a linking component to a biopolymer-substrate-mimetic or biopolymer-substrate-analog component. At least two, generally well-separated reporter moieties are included in the artificial, multifunctional substrate.

Abstract: Methods and compositions for high-throughput identification of protein/nucleic acid binding pairs are provided. In the subject methods, a nucleic acid probe array, e.g., a molecular beacon probe array, is contacted with a target nucleic acid population to produce a hybridized array. The resultant hybridized array is then contacted with a population of proteins to produce a protein bound array. Any resultant array surface bound target nucleic acid/protein complexes are then detected to identify protein/nucleic acid binding pairs. In certain embodiments, the protein and/or nucleic acid members of the identified protein/nucleic acid binding pairs are further characterized. Also provided are systems and kits for use in practicing the subject methods. The subject invention finds use in a variety of different applications.

Abstract: Methods and compositions for high-throughput identification of protein/nucleic acid binding pairs are provided. In the subject methods, a nucleic acid probe array, e.g., a molecular beacon probe array, is contacted with a target nucleic acid population to produce a hybridized array. The resultant hybridized array is then contacted with a population of proteins to produce a protein bound array. Any resultant array surface bound target nucleic acid/protein complexes are then detected to identify protein/nucleic acid binding pairs. In certain embodiments, the protein and/or nucleic acid members of the identified protein/nucleic acid binding pairs are further characterized. Also provided are systems and kits for use in practicing the subject methods. The subject invention finds use in a variety of different applications.

Abstract: Methods and compositions for high-throughput identification of protein/nucleic acid binding pairs are provided. In the subject methods, a nucleic acid probe array, e.g., a molecular beacon probe array, is contacted with a target nucleic acid population to produce a hybridized array. The resultant hybridized array is then contacted with a population of proteins to produce a protein bound array. Any resultant array surface bound target nucleic acid/protein complexes are then detected to identify protein/nucleic acid binding pairs. In certain embodiments, the protein and/or nucleic acid members of the identified protein/nucleic acid binding pairs are further characterized. Also provided are systems and kits for use in practicing the subject methods. The subject invention finds use in a variety of different applications.

Abstract: A method and system for signal generation and signal amplification from an array containing bound, unlabeled target molecules. Following exposure of the array to a sample solution containing unlabaled target RNA molecules, blunt ends are generated on each probe/target double-stranded hybrid labeled primer oligonucleotide linker is then bound to the blunt ends. Next, in an iterative, inner process, additional layers of labeled oligonucleotide, linkers are added, shell-by-shell, to form a dendrimer-like molecular complex bound through the oligonucleotide linker to the probe/target hybrid.