Abstract: An apparatus includes a first compressor, a first load, a second compressor, a second load, and a heat exchanger. The first compressor compresses a first refrigerant. The first load uses the first refrigerant to remove heat from a space proximate the first load. The first load sends the first refrigerant to the first compressor. The second compressor compresses a second refrigerant. The second load uses the second refrigerant to remove heat from a space proximate the second load. The second load sends the second refrigerant to the second compressor. The heat exchanger receives the first refrigerant from the first compressor and receives the second refrigerant from the second compressor. The heat exchanger transfers heat from the first refrigerant to the second refrigerant. The heat exchanger discharges the first refrigerant to the first load and discharges the second refrigerant to the second compressor.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Abstract: The present application provides a refrigeration system. The refrigeration system may include a suction header, a compressor, a suction header oil return line in communication with the suction header and the compressor, and an oil line control system. The oil line control system may include a sensor and a valve to open and shut the suction header oil return line in response to the sensor.

Abstract: An apparatus includes a first compressor, a first load, a second compressor, a second load, a first heat exchanger, and a second heat exchanger. The first compressor compresses a first refrigerant. The first load uses the first refrigerant to remove heat from a space proximate the first load. The first load sends the first refrigerant to the first compressor. The second compressor compresses a second refrigerant. The second load uses the second refrigerant to remove heat from a space proximate the second load. The second load sends the second refrigerant to the second compressor. The first heat exchanger receives the first refrigerant from the first compressor. The first heat exchanger transfers heat from the first refrigerant to a fluid. The second heat exchanger receives the second refrigerant from the second compressor. The second heat exchanger transfers heat from the fluid to the second refrigerant.

Abstract: Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

Abstract: An apparatus includes a compressor, a load, a heat exchanger, and a heater. The compressor compresses a refrigerant. The load uses the refrigerant to remove heat from a space proximate the load. The load sends the refrigerant to the compressor. The heat exchanger receives the refrigerant from the compressor. The heat exchanger transfers heat from a fluid to the refrigerant. The heat exchanger discharges the refrigerant to the compressor. The heater adds heat to the fluid.

Abstract: Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Abstract: An apparatus includes a compressor, a load, a heat exchanger, and a heater. The compressor compresses a refrigerant. The load uses the refrigerant to remove heat from a space proximate the load. The load sends the refrigerant to the compressor. The heat exchanger receives the refrigerant from the compressor. The heat exchanger transfers heat from a fluid to the refrigerant. The heat exchanger discharges the refrigerant to the compressor. The heater adds heat to the fluid.

Abstract: An apparatus includes a first compressor, a first load, a second compressor, a second load, and a heat exchanger. The first compressor compresses a first refrigerant. The first load uses the first refrigerant to remove heat from a space proximate the first load. The first load sends the first refrigerant to the first compressor. The second compressor compresses a second refrigerant. The second load uses the second refrigerant to remove heat from a space proximate the second load. The second load sends the second refrigerant to the second compressor. The heat exchanger receives the first refrigerant from the first compressor and receives the second refrigerant from the second compressor. The heat exchanger transfers heat from the first refrigerant to the second refrigerant. The heat exchanger discharges the first refrigerant to the first load and discharges the second refrigerant to the second compressor.

Abstract: An apparatus includes a first compressor, a first load, a second compressor, a second load, a first heat exchanger, and a second heat exchanger. The first compressor compresses a first refrigerant. The first load uses the first refrigerant to remove heat from a space proximate the first load. The first load sends the first refrigerant to the first compressor. The second compressor compresses a second refrigerant. The second load uses the second refrigerant to remove heat from a space proximate the second load. The second load sends the second refrigerant to the second compressor. The first heat exchanger receives the first refrigerant from the first compressor. The first heat exchanger transfers heat from the first refrigerant to a fluid. The second heat exchanger receives the second refrigerant from the second compressor. The second heat exchanger transfers heat from the fluid to the second refrigerant.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Abstract: Described herein are microfluidic devices and methods that can greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

Abstract: A fluidic chip includes at least one nanochannel array, the nanochannel array including a surface having a nanofluidic area formed in the material of the surface; a microfluidic area on said surface; a gradient interface area having a gradual elevation of height linking the microfluidic area and the nanofluidic area; and a sample reservoir capable of receiving a fluid in fluid communication with the microfluidic area. In another embodiment, a fluidic chip includes at least one nanochannel array, the nanochannel array includes a surface having a nanofluidic area formed in the material of the surface; a microfluidic area on said surface; and a gradient interface area linking the microfluidic area and the nanofluidic area, where the gradient interface area comprises a plurality of gradient structures, and the lateral spacing distance between said gradient structures decreases towards said nanofluidic area; and a sample reservoir capable of receiving a fluid in fluid communication with the microfluidic area.

Abstract: Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.

Abstract: The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.

Abstract: Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Abstract: Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.