Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: Improved processes for the synthesis of 2'-O-substituted pyrimidine nucleosides are provided. The processes feature alkylation of a 2,2'-anhydropyrimidine nucleoside or a 2S,2'-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Abstract: A multi-purpose hexagonal building module constructed of identically configured panels connected together at lap joints, with each panel having a large flat rectangular section and an integral smoothly curved section. When the panels are interconnected to form a hexagonal module, the relatively large rectangular flat sections collectively constitute the module's six planar walls and the relatively small smoothly curved panel sections function as rounded module corners. The module can be disposed with its central symmetrical axis vertical or horizontal, and can be used as a housing unit or as a container for product storage. The module, whether used for storage or as a living unit, and whether disposed horizontally or vertically, can be permanently mounted at a single site or made mobile by mounting on a vehicle or ship for transport across land or water.

Abstract: A xenon metal halide lamp having an improved electrode structure that is particularly suited for automotive applications is disclosed. The electrode is comprises of a tip portion that is located at one end of a shank with the shank having a filament coiled therearound. The tip and shank portions are designed to allow for high initial current during starting and low current during operation. The coil filament is situated in opposite neck portions of an envelope forming the light source so as to; (1) cause the electrodes to be axially aligned within the light source; (2) keep the shank of the electrode from intimate contact with the envelope thereby preventing the condensation of the mercury and allowing for substantial vaporization of the metal halide ingredients at the neck portion; and (3) prevent the thermal expansion of the electrode from cracking the envelope.

Abstract: A high intensity metal halide discharge lamp has a fill comprising mercury, sodium iodide and scandium triiodide plus an inert starting gas. Cadmium or zinc may be added in a molar ratio relative to ScI.sub.3 within the range of 0.04 to 1.0 to achieve a lowering in color temperature of several hundred degrees Kelvin at the cost of a minor decrease in lumens which is offset by an improvement in maintenance.

Abstract: 2-Substituted-s-triazolo[1,5a]pyrimidines are disclosed which are useful as inhibitors of phosphodiesterase enzymes or intermediates in the production process. Such compounds are of the following structure: ##STR1## wherein X, R, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter.

Abstract: Compounds of the following structure are disclosed which are effective inhibitors of the enzyme xanthine oxidase: ##STR1## R is an aromatic or substituted aromatic nucleus such as phenyl, R.sub.1 is H, an alkali metal or ammonium, and R.sub.2 is H or OR.sub.1.