Patents by Inventor Robert J. Boock
Robert J. Boock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108258Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.Type: ApplicationFiled: October 11, 2023Publication date: April 4, 2024Inventors: James H. Brauker, Peter C. Simpson, Robert J. Boock, Monica Rixman Swinney, Mark C. Brister
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Patent number: 11937927Abstract: A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.Type: GrantFiled: April 23, 2020Date of Patent: March 26, 2024Assignee: DexCom, Inc.Inventors: Peter C. Simpson, Robert J. Boock, Sebastian Bohm, James H. Brauker, Paul V. Neale
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Patent number: 11918354Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.Type: GrantFiled: December 31, 2019Date of Patent: March 5, 2024Assignee: DEXCOM, INC.Inventors: Peter C. Simpson, Robert J. Boock, Matthew Wightlin, Mark C. Shults
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Publication number: 20240041356Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the devices include a membrane that has an interference domain designed to reduce the permeation of one or more interferents.Type: ApplicationFiled: July 7, 2023Publication date: February 8, 2024Applicant: DexCom, Inc.Inventors: Jonathan Hughes, Robert J. Boock, Chris W. Dring
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Patent number: 11892426Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.Type: GrantFiled: January 29, 2021Date of Patent: February 6, 2024Assignee: Dexcom, Inc.Inventors: Michael J. Estes, Jennifer Blackwell, Sebastian Bohm, Robert J. Boock, Jack Pryor, Peter C. Simpson, Matthew D. Wightlin
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Patent number: 11864891Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.Type: GrantFiled: August 5, 2021Date of Patent: January 9, 2024Assignee: DEXCOM, INC.Inventors: Robert J. Boock, Chris W. Dring
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Patent number: 11737692Abstract: Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition.Type: GrantFiled: May 22, 2020Date of Patent: August 29, 2023Assignee: Dexcom, Inc.Inventors: Naresh C. Bhavaraju, Sebastian Bohm, Robert J. Boock, Daiting Rong, Peter C. Simpson
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Publication number: 20230248273Abstract: Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.Type: ApplicationFiled: March 27, 2023Publication date: August 10, 2023Inventors: Phil MAYOU, Hari HAMPAPURAM, David A. PRICE, Keri J. LEONE, Kostyantyn SNISARENKO, Michael Robert MENSINGER, Leif N. BOWMAN, Robert J. BOOCK, Apurv Ullas KAMATH, Eli REIHMAN, Peter C. SIMPSON
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Patent number: 11642049Abstract: Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.Type: GrantFiled: January 10, 2020Date of Patent: May 9, 2023Assignee: Dexcom, Inc.Inventors: Phil Mayou, Hari Hampapuram, David Price, Keri Leone, Kostantyn Snisarenko, Michael Robert Mensinger, Leif N. Bowman, Robert J. Boock, Apurv Ullas Kamath, Eli Reihman, Peter C. Simpson
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Publication number: 20230138407Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.Type: ApplicationFiled: December 30, 2022Publication date: May 4, 2023Applicant: DexCom, Inc.Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
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Publication number: 20230139158Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.Type: ApplicationFiled: December 27, 2022Publication date: May 4, 2023Applicant: DexCom, Inc.Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
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Publication number: 20230129853Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods.Type: ApplicationFiled: December 22, 2022Publication date: April 27, 2023Inventors: Peter C. SIMPSON, Robert J. BOOCK, Apurv Ullas KAMATH, JR., Matthew D. WIGHTLIN, Michael J. ESTES
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Patent number: 11559229Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods.Type: GrantFiled: August 9, 2019Date of Patent: January 24, 2023Assignee: Dexcom, Inc.Inventors: Peter C. Simpson, Robert J. Boock, Apurv Ullas Kamath, Matthew D. Wightlin, Michael J. Estes
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Publication number: 20220384007Abstract: A method of monitoring compliance with an insulin regimen prescribed for a diabetic patient includes receiving continuous glucose monitoring (CGM) data for the patient over a period of time; determining a degree of variability in the CGM data obtained over the period of time; evaluating compliance with the prescribed insulin regimen based at least in part on the degree of variability in the CGM data that is determined; and responsive to the evaluating, causing at least one action to be performed to facilitate a change in patient behavior that increases compliance with the prescribed insulin regimen when compliance is determined to be less than required to optimize therapeutic treatment of diabetes in the diabetic patient.Type: ApplicationFiled: August 10, 2022Publication date: December 1, 2022Inventors: Peter C. Simpson, Robert J. Boock, David DeRenzy, Laura J. Dunn, Matthew Lawrence Johnson, Katherine Yerre Koehler, Apurv Ullas Kamath, Andrew Attila Pal, David Price, Eli Reihman, Mark Wu
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Publication number: 20220214300Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.Type: ApplicationFiled: December 23, 2021Publication date: July 7, 2022Applicant: DEXCOM, INC.Inventors: Shanger Wang, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Jiong Zou
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Publication number: 20220071530Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.Type: ApplicationFiled: October 18, 2021Publication date: March 10, 2022Inventors: Robert J. Boock, Monica A. Rixman, Huashi Zhang, Michael J. Estes, Kristina Lawrence
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Publication number: 20220068452Abstract: Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.Type: ApplicationFiled: November 11, 2021Publication date: March 3, 2022Inventors: Peter C. Simpson, Robert J. Boock, David DeRenzy, Laura J. Dunn, Matthew Lawrence Johnson, Katherine Yerre Koehler, Apurv Ullas Kamath, Andrew Attila Pal, David Price, Eli Reihman, Mark Wu
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Patent number: 11262326Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.Type: GrantFiled: December 30, 2016Date of Patent: March 1, 2022Assignee: DEXCOM, INC.Inventors: Shanger Wang, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A Tapsak, Huashi Zhang, Jiong Zou
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Publication number: 20210361205Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.Type: ApplicationFiled: August 5, 2021Publication date: November 25, 2021Inventors: Robert J. Boock, Chris W. Dring
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Patent number: 11179079Abstract: Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.Type: GrantFiled: December 19, 2019Date of Patent: November 23, 2021Assignee: DexCom, Inc.Inventors: Robert J. Boock, Chris W. Dring