Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: An apparatus for connecting collar components to an elongate member is disclosed. The apparatus includes a frame structure having a central opening that is configured to receive an elongate member and that includes at least a first gripping station and a second gripping station. Each gripping station includes a reference surface and a clamp device that is configured to force a collar component against the reference surface. The first and second gripping stations are configured to control relative spatial location of a first collar component held by the first gripping station relative to a second collar component gripped by the second gripping station, prior to connecting the first and second collar components to the elongate member.

Abstract: A golf club head having a metal portion adhered to a non-metal portion to define a closed internal volume therebetween, and an elongated channel extending across a portion of the sole. The channel may be recessed from adjacent surfaces of the sole, wherein the channel comprises a center portion extending across a center of the sole, a heel portion extending from a heel end of the center portion toward the heel, and a toe portion extending from a toe end of the center portion toward the toe, wherein the width of the center portion of the channel is substantially constant, and wherein the width of the channel increases from the heel end of the center portion to the heel and from the toe end of the center portion to the toe.

Abstract: Mining apparatus is disclosed in which a cutting wheel supporting a plurality of roller-cutters rotates about a horizontal axis and is supported on a slewing boom for cutting a tunnel with a flat floor and roof and elliptical walls as it slews across a mining face. The slewing boom is supported on a main beam assembly, the front end of which rests on powered crawler tracks and the rear end of which passes through a gripper assembly which may be clamped between the floor and roof of the tunnel, and against which the main beam assembly may be urged forward for engaging the roller-cutters with the mining face. A preload crawler is urged against the roof of the tunnel above the powered crawler tracks to locate the main beam assembly rigidly relative to the tunnel such that the roller-cutters may cut the rock in the mining face with minimal loss of cutting force due to vibration.

Abstract: A mobile mining machine for cutting a tunnel in rock has a wheel-like cutterhead assembly supported by a pitch boom assembly that causes movement of the cutterhead assembly in the vertical plane. A swing boom assembly supports the pitch boom assembly and is supported by the main frame of the mobile mining machine. In one embodiment the swing boom assembly has a pivot axis that is tilted from vertical and swings the cutterhead and the pitch boom during mining to cut a tunnel having a wide, flat floor. During mining, a gripper assembly having a floor gripper shoe and a roof gripper shoe brace the mobile mining machine in the tunnel. Thrust is provided by thrust cylinders located between the gripper shoes and the main beam. Extension of the thrust cylinders moves the cutterhead assembly, main beam, and rear portion of the mobile mining machine forward relative to the gripper assembly due to slidable engagement of the main beam and gripper assembly.

Abstract: Mining apparatus in which a cutting wheel supporting a plurality of roller-cutters rotates about a horizontal axis and is supported on a slewing boom for cutting a tunnel with a flat floor and roof and elliptical walls as it slews across a mining face. The slewing boom is supported on a main beam assembly, the front end of which rests on powered crawler tracks and the rear end of which passes through a gripper assembly which may be clamped between the floor and roof of the tunnel, and against which the main beam assembly may be urged forward for engaging the roller-cutters with the mining face. A preload crawler is urged against the roof of the tunnel above the powered crawler tracks to locate the main beam assembly rigidly relative to the tunnel such that the roller-cutters may cut the rock in the mining face with minimal loss of cutting force due to vibration.

Abstract: The invention is concerned with a tobacco substitute which is made by subjecting a strand of viscose fibres to a controlled pyrolysis until the organic residue contains at least 90% carbon by weight, and loading the carbon strand with ingredients for smoking.