Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: A method of sterilizing compositions prepared from amniotic membrane tissues may include harvesting placental tissue, separation of amniotic membrane tissue, and treatment of the amniotic membrane tissue with a supercritical fluid such as carbon dioxide. Treatment with supercritical fluid may subject the amniotic membrane tissue to conditions sufficient to sterilize the tissue yet maintain at least some biological function of the sterilized composition. Compositions described herein may be used as tissue grafts, wound dressings, cell culture substrates, or other substrates for use in tissue engineering.

Abstract: Compositions and methods for creating a laminar construct for tissue-engineered dermal equivalent are provided. One composition provided herein comprises a hydrogel matrix comprising two or more hydrogels layers and a population of stem cells. Associated methods are also provided.

Abstract: The present invention provides methods and compositions for detecting an improvement in the performance of a physical or athletic activity and/or in a cognitive activity in a subject upon administration to the subject of a performance enhancing material and/or upon contact of the subject with a performance enhancing material and/or upon implementation of a performance enhancing activity by the subject by detecting in the subject a change in a biomarker associated with physical or athletic activity and/or cognitive activity.

Abstract: Compositions and methods for detection of estrogen receptor-&bgr; in human tissues are provided. The compositions are monoclonal antibodies specific for estrogen receptor-&bgr; binding. The method provided is a prognostic method and/or a predictive assay for cancer, including breast cancer. The assay provided uses a estrogen receptor-&bgr; antibody that has both high affinity and specificity and can be used in archival tissue sections.