Patents by Inventor Robert J. Cregge

Robert J. Cregge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE
    Patent number: 5529995
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: June 25, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum
  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5488048
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: March 1, 1995
    Date of Patent: January 30, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum
  • Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace
    Patent number: 5424425
    Abstract: The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: June 13, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Robert J. Cregge, Thomas L. Fevig, Shyam Sunder, Patrick W. Shum
  • 2,3-dihydro- 1-(8-methyl-1,2,4-triazolo[4,3-B]-pyridazin-6-yl)-4(1H)-pyridinone
    Patent number: 5374632
    Abstract: 2,3-Dihydro-1-(8-methyl-1,2,4-triazolo [4,3-b]pyridazin-6-yl)-4(1H)-pyridinone has been prepared in substantially pure form and has been found to be useful for alleviating bronchial spasms in mammals. Synthesis of this material through phenylselenyl intermediates is described.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: December 20, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Robert J. Cregge
  • 4-hydroxy-4-(substituted alkenyl)cyclohexanecarboxylic acids
    Patent number: 4748274
    Abstract: The present invention relates to compounds which are 4-hydroxy-4-alkenylcyclohexanecarboxylic acid derivatives possessing leukotriene antagonist activity. The compounds are useful in the treatment of allergic diseases, particularly in the treatment of human asthma. They are prepared by the reaction of an appropriate oxaspiro compound with a mercaptoalkanoic acid derivative.
    Type: Grant
    Filed: November 7, 1986
    Date of Patent: May 31, 1988
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Cregge, Nelsen L. Lentz
  • Cyclohexanealkanoic acids
    Patent number: 4622422
    Abstract: The present invention is directed to 2-hydroxy-4-alkylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention. These compounds are useful in the treatment of bronchial asthma and they are obtained by the reaction of an appropriate 2,3-epoxy-4-alkylidenecyclohexanealkanoate with a mercapto alkanoic acid ester in the presence of a tertiary amine. The indicated process gives the esters of the present invention which can be hydrolyzed to the corresponding free acids by standard procedures. The compounds described can be subjected to other known reactions to give the other compounds of the present invention.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: November 11, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Cregge, Jeffrey S. Sabol
  • 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
    Patent number: 4578464
    Abstract: 8-Methyl-1,2,4-triazolo[4,3-b]pyridazines having a hydroxyalkylamino substituent at the 6-position are described herein. The compounds involved are useful as bronchodilator agents and they are prepared by the reaction of 6-chloro-8-methyl-1,2,4-triazolo[4,3-b]-pyridazine with an appropriate amino alcohol.
    Type: Grant
    Filed: November 22, 1983
    Date of Patent: March 25, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Robert J. Cregge, John E. Coutant
  • 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators
    Patent number: 4391807
    Abstract: Substituted tetrahydroimidazo[2,1-a]phthalazine compounds such as 6-methylamino-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine are prepared by reacting a 6-halo-7,8,9,10-tetrahydroimidazo[1,2-a]phthalazine with an appropriate amine. The compounds are useful as bronchodilators.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: July 5, 1983
    Assignee: The Dow Chemical Company
    Inventors: Catherine A. Alexander, Robert J. Cregge, Norton P. Peet
  • Substituted tetrahydropyridazino-(1,6-A)benzimidazoles and use as bronchodilators
    Patent number: 4391806
    Abstract: Substituted tetrahydropyridazino[1,6-a]benzimidazole compounds such as 2-methylamino-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole are prepared by reacting a 2-halo-6,7,8,9-tetrahydropyridazino[1,6-a]benzimidazole with an appropriate amine. The compounds are useful as bronchodilators.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: July 5, 1983
    Assignee: The Dow Chemical Company
    Inventors: Catherine A. Alexander, Robert J. Cregge, Norton P. Peet