Patents by Inventor Robert J. Genco
Robert J. Genco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7767226Abstract: The present invention provides a method for facilitating repair of an area of bone by providing hemihydrate calcium sulfate particles, mixing the particles with an aqueous solution to obtain a paste, applying the paste to an area of bone in need of repair, and allowing the paste to set.Type: GrantFiled: January 30, 2008Date of Patent: August 3, 2010Assignee: The Research Foundation of State University of New YorkInventors: YoungBum Park, Rosemary Dziak, Robert J. Genco, Mark Swihart, Hiran Perinpanayagam
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Publication number: 20080213359Abstract: The present invention provides a method for facilitating repair of an area of bone by providing hemihydrate calcium sulfate particles, mixing the particles with an aqueous solution to obtain a paste, applying the paste to an area of bone in need of repair, and allowing the paste to set.Type: ApplicationFiled: January 30, 2008Publication date: September 4, 2008Inventors: YoungBum Park, Rosemary Dziak, Robert J. Genco, Mark Swihart, Hiran Perinpanayagam
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Patent number: 6407288Abstract: The present invention discloses novel naphthylsalicylanilides of the general formula wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more —H with —OH, alkyl, O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more —H atoms with CN, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.Type: GrantFiled: October 2, 2001Date of Patent: June 18, 2002Assignee: The Research Foundation of State University of New YorkInventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco
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Publication number: 20020065322Abstract: The present invention discloses novel naphthylsalicylanilides of the general formula 1Type: ApplicationFiled: October 2, 2001Publication date: May 30, 2002Inventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco
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Patent number: 6117859Abstract: A method of treating chronic inflammation in a mammal is disclosed which comprises contacting the affected area with an amount sufficient to ameliorate the inflammatory condition, of a compound of the following formula: ##STR1## wherein Z is a substituted phenyl ring, R is an alkylsulfonyl group of 1-20 carbon atoms, and X is selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl and lower haloalkyl.Type: GrantFiled: September 28, 1999Date of Patent: September 12, 2000Assignee: The Research Foundation of State University of New YorkInventors: Richard T. Evans, Robert A. Coburn, Robert J. Genco, Joseph A. Dunn
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Patent number: 5536497Abstract: Polypeptides related to fimbriae of Porphyromonas gingivalis are described and claimed which exhibit inhibition of bacterial adhesion to saliva-coated surfaces. The polypeptides are selected from the group consisting of fimbriae, fimbrillin, and fimbrial-related. peptides derived therefrom. The polypeptides are used as active ingredients in various oral formulations designed to prevent adhesion of P. gingivalis to host mucosal surfaces and thus interfering with the development of periodontitis. The polypeptides are also used in subunit vaccine formulations for use against pathogenic, fimbriated P. gingivalis in the prophylactic treatment of periodontitis. Use of the polypeptides for inducing protective immunity in serum and gingival crevicular fluid may prevent primary infection with P. gingivalis as well as the spread of the organism between intraoral reservoirs.Type: GrantFiled: December 21, 1992Date of Patent: July 16, 1996Assignee: The Research Foundation of State University of New YorkInventors: Richard T. Evans, Gurrinder S. Bedi, Robert J. Genco, Hakimuddin T. Sojar
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Patent number: 5455041Abstract: A method for inducing periodontal regeneration including soft tissue, cementum, and bone regeneration, resulting in a type of healing characteristic of the anatomy and architecture of the undiseased tissue, comprising treating the surface of the damaged root with a demineralizing agent, and then applying a growth factor directly to the treated bone surface.Type: GrantFiled: September 13, 1993Date of Patent: October 3, 1995Assignee: Research Foundation of State University of New York at BuffaloInventors: Robert J. Genco, Moon-Il Cho
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Patent number: 5432055Abstract: The present invention relates to novel compositions comprising P. gingivalis specific oligonucleotides which are useful as primers to amplify particular regions of the genome of P. gingivalis during enzymatic nucleic acid amplification. The invention also provides a method for the detection of P. gingivalis, which may be present in a clinical specimen, using the P. gingivalis-specific primers and enzymatic nucleic acid amplification. The present invention also relates to P. gingivalis-specific oligonucleotides which are useful as probes to facilitate detection of the amplified regions of P. gingivalis DNA.Type: GrantFiled: June 2, 1993Date of Patent: July 11, 1995Inventors: Mary J. Evans, Richard T. Evans, Robert J. Genco, Steven J. Greenberg, Howard K. Kuramitsu
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Patent number: 4997830Abstract: A pharmaceutical combination of Metronidazole and Amoxicillin for the treatment of periodontitis. Conventional therapeutic doses of both the Metronidazole and Amoxicillin given as a combination therapy has been unexpectedly found to effectively treat periodontitis.Type: GrantFiled: February 7, 1990Date of Patent: March 5, 1991Assignee: The Research Foundation of State University of New YorkInventors: Arie J. van Winkelhoff, Edwin G. Winkel, Ronald J. Goene, Lars A. Christersson, Joseph J. Zambon, Robert J. Genco
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Patent number: 4939132Abstract: This invention relates to new 5-alkylsulfonylsalicylanilides and methods for their use. More particularly, the invention relates to compounds of the formula: ##STR1## Wherein Z is a substituted or unsubstituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkylsulfonyl group of from 1 to 20 carbon atoms including substitutents; and X is a radical selected from the group consisting of --CN, --NO.sub.2, --H, halogen, lower alkyl or lower haloalkyl.The above compounds and compositions containing them are effective antiseptics against a wide range of microorganisms, especially bacteria, and are surprisingly highly effective against microorganisms, particularly S. mutans, prevalent in dental plaque.Type: GrantFiled: April 15, 1985Date of Patent: July 3, 1990Assignee: The Research Foundation of State University of New YorkInventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco, Michael T. Clark
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Patent number: 4741999Abstract: Actinobacillus actinomycetemcomitans has frequently been implicated in juvenile periodontitis. The present monoclonal antibodies are specific to Actinobacillus actinomycetemcomitans. The present monoclonal antibodies are typically employed as reagents which include an inert carrier, preferably a liquid, such as buffered saline solution and a preservative. The carrier compositions are suitably selected to provide for the proper dispersal of bacteria, and to preserve the integrity of antigens and supplemental structures. The selection of the proper carrier is especially important in the detection in mixtures which include bacteria which produce large amounts of autolyltic enzymes such as B. gingivalis. The monoclonal antibodies of the present invention are useful in clinical testing and differentiating antigens in the gingival or subgingival sera.Type: GrantFiled: February 26, 1986Date of Patent: May 3, 1988Assignee: The Research Foundation of State University of New YorkInventors: Robert J. Genco, Joseph J. Zambon, Lars A. Christersson, Mirdza E. Neiders
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Patent number: 4702734Abstract: This invention relates to a method for promoting periodontal regeneration in humans, the method comprising(a) application of an agent which demineralizes enamel and dentin, and subsequently(b) application of an agent which stimulates the formulation of endothelial cells.Type: GrantFiled: May 8, 1986Date of Patent: October 27, 1987Assignee: Meloy Laboratories, Inc.Inventors: Victor P. Terranova, Ulf M. E. Wikesjo, Robert J. Genco, Susanne Hic, Raymond M. Lyall
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Patent number: 4358443Abstract: The composition comprises certain 5-alkylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, and R is a substituted or unsubstituted n-alkyl or phenyl group of from 4 to 30 carbon atoms including substituents.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting a microorganism affected by the above composition with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.Type: GrantFiled: August 8, 1980Date of Patent: November 9, 1982Assignee: The Research Foundation of State University of New YorkInventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco, Armando Batista
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Patent number: 4287191Abstract: The composition comprises certain 5-acylsalicylanilides and more particularly comprises the compounds encompassed by the following generic formula: ##STR1## Where Z is a substituted phenyl ring of from 6 to 30 carbon atoms including substituents, R is a substituted or unsubstituted alkyl or phenyl group of from 2 to 30 carbon atoms including substituents and M is a radical selected from the group consisting of --C.dbd.N,--F,--NO.sub.2,--H, lower alkyl or lower haloalkyl.The preferred compositions of the invention have a partition coefficient greater than 4 and the substituted moieties in the phenyl ring of the Z group have a combined overall electron withdrawing effect on the phenyl ring of the Z group.The method of the invention comprises contacting the microorganism with a sufficient concentration of the above composition for a sufficient time to inhibit the growth of the microorganism.Type: GrantFiled: April 14, 1980Date of Patent: September 1, 1981Assignee: The Research Foundation of State University of New YorkInventors: Robert A. Coburn, Richard T. Evans, Robert J. Genco, Armando Batista