Patents by Inventor Robert James Citorik

Robert James Citorik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CFTR-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240093186
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.
    Type: Application
    Filed: September 20, 2023
    Publication date: March 21, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Aamir Mir, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, Robert James Citorik, William Edward Salomon, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240084333
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 14, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • PAH-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240082429
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.
    Type: Application
    Filed: October 26, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • SERPINA-MODULATING COMPOSITIONS AND METHODS
    Publication number: 20240084334
    Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 14, 2024
    Inventors: Robert Charles Altshuler, Anne Helen Bothmer, Daniel Raymond Chee, Cecilia Giovanna Silvia Cotta-Ramusino, Kyusik Kim, Randi Michelle Kotlar, Gregory David McAllister, Ananya Ray, Nathaniel Roquet, Carlos Sanchez, Barrett Ethan Steinberg, William Edward Salomon, Robert James Citorik, William Querbes, Luciano Henrique Apponi, Zhan Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240076698
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 7, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • TISSUE-SPECIFIC METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240042058
    Abstract: The invention provides, inter alia, systems and associated methods, for modifying DNA, such as the genome of a cell. The systems, in certain embodiments, encompass one or more tissue-specific expression-control sequences, such as promoters and microRNA binding sites in addition to a transposase (or a nucleic acid encoding the same) and a template nucleic acid comprising a sequence to be inserted into the genome of a cell, tissue, or subject.
    Type: Application
    Filed: February 25, 2022
    Publication date: February 8, 2024
    Inventors: Robert James Citorik, Jacob Rosenblum Rubens, William Edward Salomon, Zi Jun Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240035049
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: July 19, 2023
    Publication date: February 1, 2024
    Inventors: Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, William Edward Salomon, Jacob Rosenblum Rubens, Robert James Citorik, Zi Jun Wang, Kyusik Kim, Randi Michelle Kotlar, Ananya Ray, Robert Charles Altshuler, Sandeep Kumar, Nathaniel Roquet, Barrett Ethan Steinberg
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240018551
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 2, 2022
    Publication date: January 18, 2024
    Inventors: Stephen CLEAVER, Barrett Ethan STEINBERG, Jacob Rosenblum RUBENS, Robert James CITORIK, William Edward SALOMON, Zi Jun WANG
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230348939
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: November 22, 2022
    Publication date: November 2, 2023
    Inventors: Anne Helen BOTHMER, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG, Kyusik KIM, Randi Michelle KOTLAR, Ananya RAY, Robert Charles ALTSHULER, Sandeep KUMAR, Nathaniel ROQUET, Barrett Ethan STEINBERG
  • TEMPLATE GUIDE RNA MOLECULES
    Publication number: 20230332184
    Abstract: The disclosure is directed, in part, to improved systems and nucleic acids for modifying target DNA.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 19, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Anne Helen BOTHMER, Aamir MIR, John Frederick BRIONES, William Edward SALOMON
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230272430
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 1, 2022
    Publication date: August 31, 2023
    Inventors: Anne Helen BOTHMER, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG, Kyusik KIM, Randi Michelle KOTLAR, Ananya RAY, Robert Charles ALTSHULER, Sandeep KUMAR, Nathaniel ROQUET, Barrett Ethan STEINBERG
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230242899
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 1, 2022
    Publication date: August 3, 2023
    Inventors: Barrett Ethan STEINBERG, Anne Helen BOTHMER, William Edward SALOMON, Inna SHCHERBAKOVA, Cecilia Giovanna Silvia COTTA-RAMUSINO, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG
  • HOST DEFENSE SUPPRESSING METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230235358
    Abstract: The disclosure provides, e.g., compositions and methods for modulating a host response to a Gene Writer system. In some embodiments, modulation of the host response results in increased integration of a heterologous nucleic acid sequence of interest into a target genome. In some embodiments, modulation of the host response results in an increased stability, e.g., maintenance of an insertion or expression thereof. In some embodiments, modulation of the host response results in decreased cytotoxicity.
    Type: Application
    Filed: August 31, 2022
    Publication date: July 27, 2023
    Inventors: Robert James CITORIK, Jacob Rosenblum RUBENS, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Zi Jun WANG
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20230131847
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: May 20, 2022
    Publication date: April 27, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Stephen Hoyt CLEAVER, Cecilia Giovanna Silvia COTTA-RAMUSINO, Yanfang FU
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20220396813
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: January 18, 2022
    Publication date: December 15, 2022
    Inventors: Jacob Feala, Yanfang Fu, Jacob Rosenblum Rubens, Robert James Citorik, Michael Travis Mee, Molly Krisann Gibson
  • FUNCTIONALIZATION OF ENDOGENOUS BACTERIA
    Publication number: 20220033830
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Application
    Filed: March 1, 2021
    Publication date: February 3, 2022
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • Functionalization of endogenous bacteria
    Patent number: 10968454
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 6, 2021
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • TUNING MICROBIAL POPULATIONS WITH PROGRAMMABLE NUCLEASES
    Publication number: 20210071159
    Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
    Type: Application
    Filed: July 23, 2020
    Publication date: March 11, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, Mark K. Mimee
  • Tuning microbial populations with programmable nucleases
    Patent number: 10760065
    Abstract: Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: September 1, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, Mark Kyle Mimee
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20200109398
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 9, 2020
    Inventors: Jacob Rosenblum Rubens, Geoffrey A. von Maltzahn, Robert James Citorik, Barrett Ethan Steinberg, Donghui Li