Abstract: The invention enables digital music content to be downloaded to and used on a portable wireless computing device. An application running on the wireless device has been automatically adapted to parameters associated with the wireless device without end-user input (e.g. the application has been configured in dependence on the device OS and firmware, related bugs, screen size, pixel number, security models, connection handling, memory etc. This application enables an end-user to browse and search music content on a remote server using a wireless network; to download music content from that remote server using the wireless network and to playback and manage that downloaded music content. The application also includes a digital rights management system that enables unlimited legal downloads of different music tracks to the device and also enables any of those tracks stored on the device to be played so long as a subscription service has not terminated.

Abstract: A piece of equipment for on-demand food preparation, for instance on an assembly line, that can use an end-of-arm tool to retrieve and deposit food items on a horizontal surface, such as the surface of a conveyor. The end-of-arm tool may include a peel, in which the peel can be translated from a retracted position to an extended position to transfer food items. The piece of equipment may translate the peel quickly into the extended position to facilitate the retrieval of food items from the horizontal surface. The piece of equipment may be rotated to position the robotic appendage and the peel in a desired direction. The peel may include a push bar that may be movable between a withdrawn position and a push position to selectively push items off of the peel.

Abstract: The invention relates generally to illuminated signs (100) having multiple point light sources such as light emitting diode arrays as the illumination source for legend-bearing face panels and particularly to diffuser structure mountable in relation to such an array for facilitating an even distribution of light within such a sign to improve illumination of the typically translucent legend disposed on such a face panel. In particular, the invention employs a clear diffuser holder (120) that is secured to the inside surface of el the face panel thereby providing a means of removeably attaching a diffuser (130). The invention permits interchangeably employing diffusers of different colors while providing resistance to vandalism.

Abstract: A method of identifying one or more dominant asymmetry modes relating to asymmetry in an alignment mark, the method includes obtaining alignment data relating to measurement of alignment marks on at least one substrate using a plurality of alignment conditions; identifying one or more dominant orthogonal components of the alignment data, the one or more dominant orthogonal components including a number of orthogonal components which together sufficiently describes variance in the alignment data; and determining an asymmetry mode as dominant if it corresponds to an expected asymmetry mode shape which best matches one of the one or more dominant orthogonal components. Alternatively, the method includes, for each known asymmetric mode: determining a sensitivity metric; and determining an asymmetry mode as dominant if the sensitivity metric is above a sensitivity threshold.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Described herein are crystalline forms of (M)-3-chloro-4-((3,5-difluoropyridin-2-yl)methoxy-d2)-3?-fluoro-2?-(3-(2-hydroxypropan-2-yl)-1H-pyrazol-1-yl)-5?,6-dimethyl-2H-[1,4?-bipyridin]-2-one (compound 1), or a pharmaceutically acceptable salt or solvate thereof.

Abstract: A manifold with a supply passage for supplying one or more materials. The manifold has a return passage for recirculating the one or more materials. The manifold includes one or more injection valves for filling one or more corresponding mold cavities. The supply passage and the return passage are in fluid communication with the one or more injection valves.

Abstract: Systems and methods relating to dynamic spargers for generating fine bubbles within reactors such as biological and chemical reactors. A sparger system is positioned within a reactor and comprises a support plate, multiple annular shrouds engaged with the support plate, and spargers positioned within the annular shrouds defining a gap between an interior surface of the annular shroud and an exterior surface of the corresponding sparger. Liquid flows through the defined gap between an interior surface of the annular shroud and an exterior surface of the sparger. Acceleration of the liquid through the gap shears bubbles at the exterior surface of the sparger creating bubbles or fine bubbles.

Abstract: The present invention relates to a simple-to-use, phototherapy dose delivery system. More particularly, a two-component irradiator having a first component being antimicrobial light source and the second being an expendable, hollow, beam sleeve. The beam sleeve being constructed to slide partially over a bezel end of the light source thereby capturing and transforming the source light into a contained, homogeneous treatment spot of calibrated treatment intensity. The calibrated intensity enables protocols and dose times to become universally the same for all irradiators once paired with a fitting beam sleeve, regardless of spot size or spectra. In practice the beam sleeve defines the treatment spot diameter, gauges the working distance, sets the dose rate, all while blocking stray light from disrupting vision.

Abstract: The invention provides Tie-2 antibodies and fragments thereof and conjugates and methods of using the same.

Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Abstract: Helmets for applying a magnetic field to the head of a subject, comprising: a housing comprising a concave surface configured to receive a portion of the head of the subject; a motor coupled to one or more of: a first permanent magnet via a first axle along a first axis of rotation, wherein the first axle drives movement of the first magnet; a second magnet via a second axle along a second axis of rotation wherein the second axle drives movement of the second magnet; and a third magnet via a third axle along the third axis of rotation wherein the third axle drives movement of the third magnet, wherein the axes are parallel; and a fit mechanism comprising a adjuster coupled to the first magnet, wherein movement of the adjustor moves the first magnet independently of the second or the third magnet.

Abstract: A fertiliser pellet comprising: a first region of a nitrogen-providing fertiliser composition; and a second region adhered to the exterior of the first region, the second region comprising a fertiliser composition capable of providing (a) two or more alkali metal and/or alkaline earth metal nutrients and (b) sulphur.

Abstract: Disclosed herein are methods and systems for producing and processing transportation and shipping documents. Embodiments thereof effectively utilize a combination of accurate data collection of vehicle loaded packaging/parts departing a location at, e.g., an exit portal of dock, creation of an electronic BOL populated with that accurate data and other shipping information, which can launch an efficient over the road capability from initial journey to destination with enhanced visibility throughout.

Abstract: An electronic cigarette has a mouthpiece portion and a power supply portion. The mouthpiece portion has an atomizer seating to receive an atomizer. An atomizer lock is located in the atomizer seating and is moveable between an open position and a locked position. An ejection mechanism with a biased ejection surface is moveable within the atomizer seating and is biased toward an extended position. The ejection mechanism is moved to a retracted position when an atomizer is introduced to the atomizer seating; the atomizer lock grips the atomizer to hold it in a fixed position. The atomizer is ejected from the atomizer seat when the atomizer lock is opened.

Abstract: The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to interleukin-33 (IL-33). The invention provides an IL-33-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-33-binding agent to treat a disorder in a mammal that is responsive to IL-33 inhibition.

Abstract: Disclosed are methods of determining the suitability of a variable-length spectrophotometer using Patent Blue dye or AMG Blue dye. Also disclosed herein are methods of determining the suitability of a fixed path length spectrophotometer for determining protein concentration of a protein sample. AMG Blue dye may also be used to determine the suitability of fixed path length spectrophotometers.

Abstract: The present disclosure generally relates to uroflowmeters and methods for processing data generated therefrom. In one aspect, the uroflowmeter is a handheld device. The uroflowmeter includes a handle, a flow chamber coupled to the handle, and a sensor associated with the flow chamber that detects a parameter of urine received in the flow chamber. The uroflowmeter may include both reusable and disposable components. As a uroflowmeter it can identify and record data corresponding to the rate of flow over the measured duration of a void of urine, but may also timestamp the voiding act and communicate the data to an external data collection center for additional analysis and incorporation into a comprehensive voiding report or voiding diary.