Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

Abstract: Various aspects of the disclosure relate to monitoring a physical location to determine and/or predict anomalous activities. One or more machine learning algorithms may be used to analyze inputs from one or more sensors, cameras, audio recording equipment, and/or any other types of sensors to detect anomalous measurements/patterns. Notifications may be sent one or more devices in a network based on the detection.

Abstract: The invention provides an associative polymer, a powder, and a process for making a powder including, networking one or more associative polymers and one or more optional surfactants to form a wet gel, and forming a powder from the wet gel, wherein the associative polymer(s) have a weight average molecular weight of from about 10 kDa to about 2,000 kDa.

Abstract: Methods of embedding a heating circuit in an article fabricated by additive manufacturing. The methods describe techniques such as co-extruding a wire, capable of being heated, along with print material in additive manufacturing of the article, and placing a pre-shaped wire capable of being heated between adjacent layers of the article. A third method includes dispensing a wire, capable of being heated, during the additive manufacturing of the article, and compacting the wire into the printed material. An apparatus for embedding a heating circuit in an article fabricated by additive manufacturing. The apparatus contains a wire dispenser, a cutter to control the length of the wire dispensed, and a compactor capable of embedding the wire capable of being heated into the printed material. An article made by additive manufacturing is disclosed. The article contains at least one heating element embedded in the article during the additive manufacturing process.

Abstract: Dynamically generating data tests includes: receiving test templates and metadata for a plurality of data objects and, on a trigger condition: based on at least the metadata and the test templates, determining a current set of templated data tests, wherein determining the current set of templated data tests comprises: determining at least one templated data test, from a prior set of templated data tests, to cease using; determining at least one templated data test to add to the current set of templated data tests; and determining, within the current set of templated data tests, at least one templated data tests to regenerate; generating the at least one templated data test to add to the current set of templated data tests; regenerating the least one templated data test to regenerate; and executing templated data tests, within the set of current templated data tests, on the plurality of data objects.

Abstract: A control system may include a processor, a power source, optionally an antenna, optionally a communication device, optionally one or more cameras, one or more motion sensors, and optionally one or more electromechanical latches. The one or more motion sensors are configured to create signals indicative of one or both of: a presence of a target animal, or a direction of travel of an animal, wherein the processor is configured to process the signals indicative of one or both of: a presence of the target animal, or the direction of travel of an animal, and wherein the system is configured to output an actuation signal to actuate closure of one or more containments of a remote trap structure based on one or both of: the determined presence of the animal, or the determined direction of travel of the animal.

Abstract: The present disclosure provides vent nibs for use with (e.g., incorporation into) a woodwind instrument, such as a bassoon.

Abstract: A trap for large animals. The system utilizes multi-containment areas for improved efficiency in herd animal trapping. The outer containment zone of the system is designed in such a way to promote animals further into the inner containment zone. The improved efficiency lowers overall cost of trap operation in terms of time, consumable bait replenishment and number of attempts on target animal groups. The system allows for independent and remote actuation of containment zone gates. Data is transmitted to a remote user and remote actuation of attracting or deterring audio can be done during trapping process. The architecture of the trap dissuades animals capable of jumping from doing so over the containment walls.

Abstract: The present disclosure provides improved octave key systems for use with (e.g., incorporation into) an instrument in the bassoon family.

Abstract: The invention relates generally to chimeric viral fusion proteins comprising the ectodomain and optionally the transmembrane domain of a first viral fusion protein (e.g., a spike protein of a coronavirus) and the cytoplasmic domain of a second viral fusion protein (e.g. RSV), immunogenic compositions comprising such chimeric proteins, and methods of use of same.

Abstract: Embodiments of the present disclosure relate to mount apparatuses for digital micromirror devices of digital lithography systems and methods of mounting the digital micromirror devices. The mount apparatuses described herein retain spatial light modulators, such as DMDs. The mount apparatus enables the flattening of the DMD by providing a force such that the pair of contact pads contact the DMD. The DMD is positioned in a mounting frame of the mount apparatus. Contact pads of the mounting frame are operable to apply pressure to the DMD.

Abstract: Embodiments disclosed herein include electronic packages. In an embodiment, an electronic package comprises a substrate with a first surface and a second surface, where the substrate comprises glass. In an embodiment, the electronic package further comprises a via opening through the substrate, where sidewalls of the via opening have a root mean squared (RMS) surface roughness that is approximately 100nm or greater. In an embodiment, the electronic package further comprises a liner over the sidewalls of the via opening, where an RMS surface roughness of the liner is approximately 50nm or smaller. An electronic package may further comprise a via through the via opening.

Abstract: A content processing system for an amusement park attraction includes a processor configured to receive a data stream including one or more control instructions for output of amusement content. The processor is also configured to identify one or more operational characteristics of an accessory. The processor is also configured to, based on the one or more operational characteristics, effectuate modification of the data stream to generate a modified data stream including one or more updated control instructions for output of adjusted amusement content to be presented to a user via the accessory. The processor is also configured to transmit the modified data stream to the accessory.

Abstract: A washing machine includes a power source, a drum, and a transmission. The transmission is configured to deliver power from the power source to the drum. The transmission includes a housing, a shaft, and a bushing. The housing defines a cavity. The shaft is disposed within the cavity and is configured to receive power from the power source. The bushing is disposed about the shaft. The bushing defines grooves that establish fluid communication between the cavity and a space that is defined between an inner diameter of the bushing and an outer diameter of the input shaft.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: A washing machine includes a power source, a drum, and a transmission. The transmission is configured to deliver power from the power source to the drum. The transmission includes a housing, a shaft, and a bushing. The housing defines a cavity. The shaft is disposed within the cavity and is configured to receive power from the power source. The bushing is disposed about the shaft. The bushing defines grooves that establish fluid communication between the cavity and a space that is defined between an inner diameter of the bushing and an outer diameter of the input shaft.

Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

Abstract: Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I. wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.

Abstract: The present disclosure provides improved octave key systems for use with (e.g., incorporation into) an instrument in the bassoon family.

Abstract: Use of a subcutaneously administered dose of between about 1.25 mg and 1.75 mg of bremelanotide or a pharmaceutically acceptable salt of bremelanotide for the treatment of female sexual dysfunction in women while reducing or minimizing undesirable side effects.