Abstract: A detection system includes a planar plasmonic element for analyzing an analyte, the plasmonic element having dielectric and metallic regions, the plasmonic element emitting light that carries detected information; and a planar two-dimensional image sensor positioned in non-parallel angled relationship with respect to a plane of the plasmonic element to enhance a spatial image resolution for the light that carries detected information with respect to at least a portion of the light.

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

Abstract: A spectroscopic device, which may be a handheld spectroscopic light source, which uses ambient light as a primary broadband light source, but which may be supplemented with an auxiliary light source to supplement band regions which may be deficient in the broad band source. The spectroscopic device makes use of a number of parallel control channels to monitor for sufficient light and to compensate for variations in the input light levels.

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

Abstract: A spectroscopic measurement system, which may utilize multiple plasmonic filters associated with a cuvette to monitor different wavelengths of light. The spectroscopic measurement system may measure absorbance and or fluorescence, and may have built-in low cost CMOS image sensor(s). Reagents and samples may be introduced to the cuvette from a fluidics manifold. Multiple sets of combined cuvettes, image sensors and plasmonic filters may utilize a single fluidics manifold for reagent and sample distribution.

Abstract: A spectroscopic device, which may be a handheld spectroscopic light source, which uses ambient light as a primary broadband light source, but which may be supplemented with an auxiliary light source to supplement band regions which may be deficient in the broad band source. The spectroscopic device makes use of a number of parallel control channels to monitor for sufficient light and to compensate for variations in the input light levels.

Abstract: A spatial filter is made by forming a structure comprising a focusing element and an opaque surface, the opaque surface being disposed remotely from the focusing element in substantially the same plane as a focal plane of the focusing element; and by forming a pinhole in the opaque surface at or adjacent to a focal point of the focusing element by transmitting a substantially collimated laser beam through the focusing element so that a point optimally corresponding to the focal point is identified on the opaque surface and imperfection of the focusing element, if any, is reflected on the shape and position of the pinhole so formed.

Abstract: A detection system includes a planar plasmonic element for analyzing an analyte, the plasmonic element having dielectric and metallic regions, the plasmonic element emitting light that carries detected information; and a planar two-dimensional image sensor positioned in non-parallel angled relationship with respect to a plane of the plasmonic element to enhance a spatial image resolution for the light that carries detected information with respect to at least a portion of the light.

Abstract: A device for detecting an analyte includes a light source emitting substantially monochromatic light; a two-dimensional diffraction element that interacts with the light from the light source, the diffraction element having one or more features that can generate plasmon waves upon receipt of the light from the light source, at least some of the features being configured to interact with the analyte; and a two-dimensional image sensor facing the diffraction element to receive diffracted light from the diffraction element so as to detect a diffraction pattern projected thereto and to measure a two-dimensional spatial change in the diffraction pattern that occurs as a result of the analyte interacting with the feature of the diffraction element.

Abstract: A spectroscopic measurement system, which may utilize multiple plasmonic filters associated with a cuvette to monitor different wavelengths of light. The spectroscopic measurement system may measure absorbance and or fluorescence, and may have built-in low cost CMOS image sensor(s). Reagents and samples may be introduced to the cuvette from a fluidics manifold. Multiple sets of combined cuvettes, image sensors and plasmonic filters may utilize a single fluidics manifold for reagent and sample distribution.

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.

Abstract: An integrated plasmonic sensing device is monolithically integrated and provides marker-free detection (eliminating the need to use fluorescent or absorbing markers) and in-situ monitoring of conditions at each detection region. The integrated plasmonic sensing device includes a plasmonic backplane disposed on a monolithically integrated image sensor. One or more plasmonic scattering regions and one or more plasmonic via regions laterally offset from the plasmonic scattering regions are provided in the plasmonic sensing device. Guided plasmonic modes mediate power transfer through the plasmonic backplane to one or more underlying image sensor pixels.