Patents by Inventor Robert K. Dinello
Robert K. Dinello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9052314Abstract: In some aspects, provided are methods relating to the use of bacterial N-methyl-2 superfamily proteins as a biomarker for the presence of bacteria in a sample. The invention also relates to novel methods of diagnosis of the presence of bacteria in a liquid or solid sample, detection of bacterial infections in humans or animals, and use of antibodies or other specific binding molecules capable of binding to N-methyl-2 superfamily proteins.Type: GrantFiled: March 14, 2013Date of Patent: June 9, 2015Assignee: SILVER LAKE RESEARCH CORPORATIONInventors: Robert K. DiNello, Mark Geisberg
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Publication number: 20140273022Abstract: In some aspects, provided are methods relating to the use of bacterial N-methyl-2 superfamily proteins as a biomarker for the presence of bacteria in a sample. The invention also relates to novel methods of diagnosis of the presence of bacteria in a liquid or solid sample, detection of bacterial infections in humans or animals, and use of antibodies or other specific binding molecules capable of binding to N-methyl-2 superfamily proteins.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Inventors: Robert K. DiNello, Mark Geisberg
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Publication number: 20130137189Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: ApplicationFiled: January 18, 2013Publication date: May 30, 2013Applicant: Relia Diagnostic Systems, Inc.Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 8354270Abstract: An embodiment of the present invention provides a-method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: October 8, 2007Date of Patent: January 15, 2013Assignee: Relia Diagnostic SystemsInventors: Alan J. Polito, Richard M. Thayer, Robert K. Dinello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Publication number: 20120064637Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: June 3, 2011Publication date: March 15, 2012Applicant: Relia Diagnostic Systems, Inc.Inventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Patent number: 7955791Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: April 20, 2009Date of Patent: June 7, 2011Assignee: Relia Diagnostic SystemsInventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Publication number: 20110076781Abstract: The present invention provides a test strip with an expanded dynamic range for performing an assay to determine the presence of, or measure the quantity of, an analyte in a sample. It also provides methods for determining the presence of, or measuring the quantity of, an analyte in a sample, and for detecting a prozone sample.Type: ApplicationFiled: April 14, 2010Publication date: March 31, 2011Applicant: RELIA DIAGNOSTIC SYSTEMS, INC.Inventors: Hongjian Liu, Robert K. DiNello, Jimmy Z. Zhang, George H. Sierra, Zhihai Ye, Xiaohong He, Zhibo Wu
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Publication number: 20090257915Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: April 20, 2009Publication date: October 15, 2009Applicant: RELIA DIAGNOSTIC SYSTEMS, INC.Inventors: Robert K. Dinello, Alan J. Polito, Stella S. Quan
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Patent number: 7521196Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: June 7, 2007Date of Patent: April 21, 2009Assignee: ReLia Diagnostic Systems, LLCInventors: Robert K. Dinello, Alan J. Polito, Stella Quan
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Patent number: 7309611Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: June 14, 2004Date of Patent: December 18, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 7297529Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: August 4, 2003Date of Patent: November 20, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 7229839Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: GrantFiled: January 17, 2003Date of Patent: June 12, 2007Assignee: Relia Diagnostic Systems, LLCInventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Publication number: 20040241882Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: June 14, 2004Publication date: December 2, 2004Applicant: PRAXSYS BIOSYSTEMS, LLC.Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 6767710Abstract: A test strip and method for detecting an analyte present in a sample.Type: GrantFiled: March 30, 2001Date of Patent: July 27, 2004Assignee: PraxSys BioSystems, LLCInventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Publication number: 20040018637Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: ApplicationFiled: March 19, 2003Publication date: January 29, 2004Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Publication number: 20030157729Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: ApplicationFiled: January 17, 2003Publication date: August 21, 2003Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Patent number: 6528323Abstract: A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.Type: GrantFiled: June 14, 1999Date of Patent: March 4, 2003Assignee: Praxsys Biosystems, Inc.Inventors: Richard M. Thayer, Alan J. Polito, Robert K. Dinello, George H. Sierra, Henry J. Wieck
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Publication number: 20020173050Abstract: A test strip and method for detecting an analyte present in a sample.Type: ApplicationFiled: March 30, 2001Publication date: November 21, 2002Inventors: Robert K. DiNello, Alan J. Polito, Stella S. Quan
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Patent number: 6136610Abstract: An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.Type: GrantFiled: November 23, 1998Date of Patent: October 24, 2000Assignee: PraxSys BioSystems, Inc.Inventors: Alan J. Polito, Richard M. Thayer, Robert K. DiNello, George H. Sierra, Dennis Nixon, Alan Phillips, Stuart Neubarth
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Patent number: 4687735Abstract: Improved sensitive immunoassays are provided involving channeling involving one, usually two enzymes, where the enzymes are related by the product of one enzyme being the substrate of the other enzyme. A dispersed aggregation is formed in the assay medium of (1) the analyte, (2) one of the enzymes bound to a second binding member ("SBM") (enzyme - SBM conjugate) which conjugate is non-covalently bound to a first binding member ("FBM"), and (3) a multiplied amount of the other enzyme bound in the complex. The large amount of enzyme or reactant in the complex is achieved by having a multiplicity of linkages binding the enzyme or reactant directly or indirectly to FBMs. The enzyme channeling provides for a detectable signal which can be related to the amount of analyte in the medium.Type: GrantFiled: March 14, 1983Date of Patent: August 18, 1987Assignee: Syntex (U.S.A.) Inc.Inventors: Robert K. DiNello, Ian Gibbons, Edwin F. Ullman