Abstract: An alert system has a first device configured to be secured to a first person, a second device associated with a second person, and a computing system. The computing system is configured to determine when the first device has breached a first geofence associated with the second device and, upon determining the first device has breached the first geofence, alert the first device, the second device, and a third device. The first device is configured to, upon receiving an alert indicating the first geofence has been breached, emit an alert signal on the first device. The second device is configured to, upon receiving an alert indicating the first geofence has been breached, emit an alert signal on the second device.

Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

Abstract: A slidable storage system adapted for use in a pickup truck bed includes a substantially planar, slidable base. The base has a cab-side edge, at least first and second opposing substantially parallel side edges and a rear-access edge opposite and substantially in parallel to the cab-side edge. A base cab wall, at least first and second substantially opposing base sidewalls and a base rear access wall extend substantially perpendicularly up from the cab-side edge, the first and second opposing substantially parallel side edges and the rear-access edge, respectively, for a fixed height (H) forming a storage volume. Positioning the slidable storage system on the pickup truck bed, with the rear tailgate wall in an “up” position, the base will not slide past the rear tailgate wall and with the rear tailgate wall in a “down” position, the base slides out past the rear tailgate wall, enabling ready access.

Abstract: Provided herein are aminoglycoside compounds, such as compounds of formula (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), or (VIIb) or pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers of any of the foregoing, useful as therapeutic or prophylactic agents. Also provided herein are methods for their preparation. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection.

Abstract: Systems, methods, and non-transitory media are provided for a collaborative smart screen for patient consultations. An example method can include presenting, at a display device, a suggested consultation action during a patient consultation at the medical care site, the suggested consultation action being based on patient data associated with a patient; presenting, at the display device and during the patient consultation, a portion of patient data contextually relevant to the suggested consultation action, the patient consultation, and the patient; and based on one or more measurements generated from the suggested consultation action, updating the portion of patient data presented at the display device.

Abstract: A slidable storage system adapted for use in a pickup truck bed includes a substantially planar, slidable base. The base has a cab-side edge, at least first and second opposing substantially parallel side edges and a rear-access edge opposite and substantially in parallel to the cab-side edge. A base cab wall, at least first and second substantially opposing, base sidewalls and a base rear access wall extend substantially perpendicularly up from the cab-side edge, the first and second opposing substantially parallel side edges and the rear-access edge, respectively, for a fixed height (H) forming a storage volume. Positioning the slidable storage system on the pickup truck bed, with the rear tailgate wall in an “up” position, the base will not slide past the rear tailgate wall and with the rear tailgate wall in a “down” position, the base slides out past the rear tailgate wall, enabling ready access.

Abstract: An improved Plasma Enhanced Atomic Layer Deposition (PEALD) system and related operating methods are disclosed. A vacuum reaction chamber includes a vacuum system that separates a first outflow from the reaction chamber, comprising unreacted first precursor, from a second outflow from the reaction chamber, comprising second precursor and any reaction by products from the reaction of the second precursor with the coating surfaces. A trap, including trap material surfaces, is provided to remove first precursor from the first outflow when the first precursor reacts with the trap material surfaces. When the second precursor includes a plasma generated material, the second precursor is not passed through the trap. An alternate second precursor source injects a suitable second precursor into the trap to complete a material deposition layer onto the trap surfaces thereby preparing the trap material surfaces to react with the first precursor on the next material deposition cycle.

Abstract: An improved Plasma Enhanced Atomic Layer Deposition (PEALD) system and related operating methods are disclosed. A vacuum reaction chamber includes a vacuum system that separates a first outflow from the reaction chamber, comprising unreacted first precursor, from a second outflow from the reaction chamber, comprising second precursor and any reaction by products from the reaction of the second precursor with the coating surfaces. A trap, including trap material surfaces, is provided to remove first precursor from the first outflow when the first precursor reacts with the trap material surfaces. When the second precursor includes a plasma generated material, the second precursor is not passed through the trap. An alternate second precursor source injects a suitable second precursor into the trap to complete a material deposition layer onto the trap surfaces thereby preparing the trap material surfaces to react with the first precursor on the next material deposition cycle.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Abstract: An embodiment of a device for automatically executing a process of generating an emulsion containing nucleic acids, amplifying the nucleic acids in the emulsion, breaking the emulsion, and separating and purifying said amplified nucleic acids, is described that comprises an emulsion generation unit for sealing beads to which nucleic acids are bound in a water-in-oil type emulsion; a nucleic acid amplification unit provided with a reaction vessel for amplifying said nucleic acids and a heating and cooling part for heating and cooling the reaction vessel; an emulsion breaking unit for breaking the emulsion after nucleic acid amplification; and a nucleic acid purification unit for recovering said amplified nucleic acids from said emulsion breaking unit.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Abstract: An improved Plasma Enhanced Atomic Layer Deposition (PEALD) system and related operating methods are disclosed. A vacuum reaction chamber includes a vacuum system that separates a first outflow from the reaction chamber, comprising unreacted first precursor, from a second outflow from the reaction chamber, comprising second precursor and any reaction by products from the reaction of the second precursor with the coating surfaces. A trap, including trap material surfaces, is provided to remove first precursor from the first outflow when the first precursor reacts with the trap material surfaces. When the second precursor includes a plasma generated material, the second precursor is not passed through the trap. An alternate second precursor source injects a suitable second precursor into the trap to complete a material deposition layer onto the trap surfaces thereby preparing the trap material surfaces to react with the first precursor on the next material deposition cycle.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Abstract: Antibacterial compounds of formula (I) are provided: as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.