Abstract: This disclosure relates to SARS-CoV-2 antibodies disclosed herein and specific binding fragments thereof, therapeutic and diagnostic uses, and compositions related thereto. In certain embodiments, this disclosure relates to antibodies disclosed herein and specific binding fragments thereof wherein the antibody or fragment specifically binds to an epitope expressed on a SARS-CoV-2 particle such as the spike protein or receptor binding domain. In certain embodiments, this disclosure relates to treating or preventing a SARS-CoV-2 or related coronavirus infection comprising administering an effective amount of an antibody disclosed herein or specific binding fragments thereof to a subject in need thereof.

Abstract: This disclosure relates to coronavirus assays, diagnostic methods, treatment methods, and compositions related thereto. In certain embodiments, this disclosure relates to ACE2 receptor binding domain peptides and uses in serological assays and vaccination methods.

Abstract: A vent for mobile living quarters has a base and a cover coupled to the base. The cover is connected to the base and pivots about a hinge by a mechanism that is coupled to a moving bar. The moving bar is attached to the cover by fasteners on one end and an alignment tab on the opposite end. The cover is user-replaceable from the top side without having to move or disconnect the mechanism. To replace the cover, fasteners are removed and the cover is pivoted away from the moving bar, where the alignment tab disengages from the cover. The cover is then slidable along the hinge to completely remove the cover from the base. A new replacement cover is slid along the hinge and the alignment tab is engaged with the replacement cover. The cover is pivoted down to a closed position and the fasteners are reinstalled.

Abstract: A vent for mobile living quarters has a base and a cover coupled to the base. The cover is connected to the base and pivots about a hinge by a mechanism that is coupled to a moving bar. The moving bar is attached to the cover by fasteners on one end and an alignment tab on the opposite end. The cover is user-replaceable from the top side without having to move or disconnect the mechanism. To replace the cover, fasteners are removed and the cover is pivoted away from the moving bar, where the alignment tab disengages from the cover. The cover is then slidable along the hinge to completely remove the cover from the base. A new replacement cover is slid along the hinge and the alignment tab is engaged with the replacement cover. The cover is pivoted down to a closed position and the fasteners are reinstalled.

Abstract: Provided herein, in some embodiments, are methods and compositions for treatment of subjects with ?-thalassemia and subjects with severe sickle cell disease using autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells.

Abstract: Examples disclosed herein relate to one or more wrench devices. An apparatus may include a drive gear assembly configured to be coupled to a power source. The drive gear assembly may include a plurality of drive gears. The apparatus may include a cam assembly coupled to the drive gear assembly. The cam assembly may include a first cam and a second cam. Further, the first cam and the second cam may be configured to interact with each other to move a part.

Abstract: A device and method for measuring the quality of a vehicle oil change and the condition of oil obtained during an oil change is provided which includes an oil measurement compartment and at least one coolant sensor. The oil measurement compartment includes a conductivity sensor including a pair of horizontal parallel wires and a pair of vertical parallel wires which are capable of measuring the quantity, temperature, and conductivity of the drained oil. The coolant sensor is comprised of a hydrophilic material in contact with a permanent surface comprised of two spaced apart metal wires or traces. The coolant sensor measures the viscosity, coolant concentration, and overall condition of the oil.

Abstract: A device and method for measuring the quality of a vehicle oil change and the condition of oil obtained during an oil change is provided which includes an oil measurement compartment and at least one coolant sensor. The oil measurement compartment includes a conductivity sensor including a pair of horizontal parallel wires and a pair of vertical parallel wires which are capable of measuring the quantity, temperature, and conductivity of the drained oil. The coolant sensor is comprised of a hydrophilic material in contact with a permanent surface comprised of two spaced apart metal wires or traces. The coolant sensor measures the viscosity, coolant concentration, and overall condition of the oil.

Abstract: The present invention relates to methods and compositions for treating RA in subjects in need thereof. The invention also relates to kits and pharmaceutical packs comprising compositions and dosage forms.

Abstract: A system for measuring light absorption levels includes a light source providing a light beam and a container for a liquid. The container includes an opening to provide access to the liquid. A prism is disposed over the opening and is operable to direct at least a first portion of the light beam toward the opening to the liquid such that the at least a portion of the first portion of the light beam is reflected back from the liquid forming an attenuated beam. A detector is operable to measure at least one of a portion of the attenuated beam and a second portion of the light beam. The detector is operable to produce at least one of a liquid measurement signal and a reference signal. A device is operable to compute a ratio of the liquid measurement signal to the reference signal to determine a signal ratio.

Abstract: A system for measuring light absorption levels for a liquid for use in a printing system includes a light source adapted to provide a divergent beam of light, a liquid container with a hole that acts as a focusing lens, and a prism disposed over the hole to split the divergent beam of light into a reference beam and a measurement beam. The systems include a measurement detector to measure the intensity of the focused beam to produce a liquid measurement signal. A reference detector measures the intensity of the reference beam for compensating the effects of temperature and light source variations on the system signals. A device calculates signal ratios and stores the ratios so that the signal ratios of subsequent colored liquids can be converted into colorant concentrations from a look-up table or through calculations using a signal ratio/colorant concentration.

Abstract: The present invention relates to therapeutic combinations comprising VX-497, ribavirin, and interferon. The present invention also relates to methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.