Abstract: A client device encodes at least two datasets using one or more encoding functions to generate encoded data portions that are encrypted using a first key according to an approximate Fully Homomorphic Encryption (FHE) scheme to generate encrypted data portions that are sent to a plurality of servers. Encrypted results are received from at least a subset of servers of the plurality of servers. Each encrypted result is calculated by a respective server using at least two encrypted data portions received by the server. The encrypted results are decrypted using a secret key according to the approximate FHE scheme to derive decrypted encoded results that are decoded using an approximate decoding function. In one aspect, an encrypted result is calculated by each server by evaluating a multivariate function using the at least two encrypted data portions received by the server.

Abstract: Intelligent subscriber identity module (SIM) switching for user equipment (UE) devices is disclosed. The UE may have multiple SIMs for multiple carrier networks (i.e., mobile network operators (MNOs) that provide wireless network infrastructure, such as radio access networks (RANs)) or a universal SIM. It may be desirable to switch between SIMs for various reasons, such as based on network quality criteria, subscription criteria, agreement criteria between MNOs, etc. These criteria may inform a policy for determining which SIM to use.

Abstract: A method for fabricating a semiconductor device includes forming air gaps within respective dielectric layer portions to reduce thermal cross-talk between adjacent bits. Each of the dielectric portions is formed on a substrate each adjacent to sidewall liners formed on sidewalls of a phase change memory (PCM) layer. The method further includes forming a pillar including the sidewall liners and the PCM layer, and forming a selector layer on the pillar and the dielectric portions.

Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: A hairstyling apparatus is described. It includes a barrel with a hairstyling surface and a central axis, the barrel has a first end and a second end. A heating element heats the hairstyling surface. An arm having a comb feature and a toggle is attached near the barrel first end and wherein the arm is repositionable with respect to the hairstyling surface. Adjustment of the arm changes an amount of contact between the comb feature and the hairstyling surface of the barrel.

Abstract: A wearable cardioverter defibrillator system includes a support structure that a patient can wear. The system also includes electrodes that contact the patient, and define two or more channels from which ECG signals are sensed. A processor may evaluate the channels by analyzing their respective ECG signals, to determine which contains less noise than the other(s). The analysis can be by extracting statistics from the ECG signals, optionally after first processing them, and then by comparing these statistics. These statistics may include tall peak counts, amplitudes of peaks compared to historical peak amplitudes, signal baseline shift, dwell time near a baseline, narrow peak counts, zero crossings counts, determined heart rates, and so on. Once the less noisy signal is identified, its channel can be followed preferentially or to the exclusion of other channels, for continuing monitoring and/or determining whether to shock the patient.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: A wearable medical includes a walking detector module with a motion sensor that is configured to detect when the patient is walking or running. In embodiments, a parameter (referred to herein as a “Bouncy” parameter) is determined from Y-axis acceleration measurements. In some embodiments, the Bouncy parameter is a measurement of the AC component of the Y-axis accelerometer signal. This detection can be used by the medical device to determine how and/or whether to provide treatment to the patient wearing the medical device. For example, when used in a WCD, the walking detector can prevent “false alarms” because a walking patient is generally conscious and not in need of a shock.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: A device may include image processing circuitry that generates image data corresponding to an image to be displayed during a first image frame and a second image frame. However, the image data is not regenerated for the second image frame. The device may also include an electronic display having a frame buffer that receives and stores the image data from the image processing circuitry. The electronic display may also include a display panel that displays the image during the first image frame based on a first read of the image data from the frame buffer in response to a first emission sync signal and displays the image during the second image frame based on a second read of the image data from the frame buffer in response to a second emission sync signal.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: An optical construction includes optical stacks arranged across the construction and spaced apart from each other. Each of the optical stacks has a transmittance of at least 60% for at least one visible wavelength and includes one or more electrically conductive layers. The optical stacks are co-extensive with first and second antennas. Each of the electrically conductive layers defines a through opening aligned with at least one of the first and second antennas. For each of an s-polarized first incident signal incident on the optical construction in a first incident plane and a p-polarized second incident signal incident on the optical construction in a second incident plane orthogonal to the first incident plane, for at least one frequency in a range from 0.5 GHz to 10 GHz, and for incident angles of up to 40 degrees, the optical construction has a transmission coefficient of between 0 dB and ?10 dB.

Abstract: Described herein is a polyamide composition (P) including specific flat glass fibres (B) with elongated shape having a non-circular cross-sectional area. The polyamide composition (P) is advantageously used for the production of molded parts. Also described herein is a method of using molded parts obtainable by molding of the polyamide composition (P) to produce mechanical parts. The molded parts are characterized by having improved fatigue resistance properties. Also described herein is a polyamide composition (P) including PA 6.6 as polyamide (A) and flat glass fibres (B).

Abstract: Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

Abstract: Improvements in distributed ledger technology for capturing, maintaining and updating data for asset-backed securitizations are described. The invention provides a distributed ledger platform which automates the capture of specified data regarding the underlying financial assets, including owners, trustees, servicers and other parties associated with asset-backed securitizations, and stores and maintains the data in a blockchain to provide users with a secure, reliable, immutable and distributed ledger of the data and to generate custom data reports of information stored in the ledger. An offchain database may be maintained in synchrony with the blockchain to allow for reduced computational load. The invention also provides a mechanism for managing changes in the data using a smart contract based consensus mechanism, for example, to record securitization party replacements in an automated manner.