Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.

Abstract: A hose includes a fluorothermoplastic or thermoplastic polyester elastomer tube layer, a nitrile rubber friction layer disposed over the tube layer, a reinforcement layer disposed over the friction layer, the reinforcement layer comprising braided steel wire, and a cover layer disposed over the reinforcing layer, where the cover layer may comprise chlorinated polyethylene. The tube layer defines a lumen in the hose, and a vapor return line is disposed within the lumen of the hose, where the vapor return line may be based upon thermoplastic polyester elastomer. Hose embodiments of the disclosure may be useful in fueling applications for vehicles using fuels such as gasoline, gasohol, diesel, biodiesel, avgas or jet fuel.

Abstract: The present disclosure relates to one or more modified avian-virus based agents, therapies, treatments, and methods of use of the modified avian-virus based agents and/or therapies and/or treatments for cancer. The disclosure also provides for methods of generating modified avian-virus based agents.

Abstract: A hose includes an inner tube defining a central longitudinal axis there through, and is formed of a vulcanized rubber and a plurality of rod shaped particles orientated substantially parallel with the central longitudinal axis, along with other typical materials. The inner tube has a tube wall thickness (t) of between about 0.5 mm to about 1.5 mm, and the plurality of rod shaped particles is incorporated in an amount of 10% or less by weight. The hose further includes a tie layer directly surrounding the inner tube, a first reinforcement layer surrounding the tie layer, and at least a second reinforcement layer surrounding the first reinforcement layer. An interlayer is interposed between the first and the second reinforcement layer, and the interlayer bonds the first reinforcement layer to the second reinforcement layer. An outside cover surrounds the second reinforcement layer, as well as any additional layers.

Abstract: A hose includes an inner tube, a cover, and at least three reinforcement layers applied between the inner tube and the cover, where two immediately adjacent reinforcement layers of the at least three reinforcement layers are applied in same spiral directions (+) (+), and where another reinforcement layer of the at least three reinforcement layers is applied in an opposing spiral direction (?). The inner tube may have a tube wall thickness (t) of between about 0.5 mm to about 1.5 mm, and the hose may have a wall thickness (T), where the tube wall thickness (t) may be less than about 25% of the hose wall thickness. Optional tie layers may be disposed between the at least three reinforcement layers. The inner tube may include rod shaped particles orientated substantially parallel with the central longitudinal axis of the hose.

Abstract: A hose includes an inner tube defining a central longitudinal axis there through, and is formed of a vulcanized rubber and a plurality of rod shaped particles orientated substantially parallel with the central longitudinal axis, along with other typical materials. The inner tube has a tube wall thickness (t) of between about 0.5 mm to about 1.5 mm, and the plurality of rod shaped particles is incorporated in an amount of 10% or less by weight. The hose further includes a tie layer directly surrounding the inner tube, a first reinforcement layer surrounding the tie layer, and at least a second reinforcement layer surrounding the first reinforcement layer. An interlayer is interposed between the first and the second reinforcement layer, and the interlayer bonds the first reinforcement layer to the second reinforcement layer. An outside cover surrounds the second reinforcement layer, as well as any additional layers.

Abstract: A hose includes a fluorothermoplastic tube layer, a nitrile rubber friction layer disposed over the tube layer, a reinforcement layer disposed over the friction layer, the reinforcement layer comprising braided steel wire, and a cover layer disposed over the reinforcing layer, where the cover layer may comprise chlorinated polyethylene. The tube layer defines a lumen in the hose, and a vapor return line may further be disposed within the lumen of the hose. Hose embodiments of the disclosure may be useful in fueling applications for vehicles using fuels such as gasoline, gasohol, diesel, biodiesel, avgas or jet fuel.

Abstract: A hose comprising a core layer, an elastomeric friction layer overlaying the core layer, at least one reinforcement layer overlaying the friction layer, and a cover layer overlaying the at least one reinforcement layer, wherein the core layer is comprised of a blend of two different non-plasticized polyamides.

Abstract: A battery powered electronic counter with an electronic accumulator (12), a switch (22) for resetting the accumulator (12) and disconnecting the battery (20), and an accumulator indexing circuit with a first pair of switch input terminals (28) having separate high and low impedance connections to the battery (2) for minimizing battery drain and reducing input signal noise sensitivity, a second pair of AC/DC input terminals (30) for receiving an input pulse of up to 250 volts and a transistor circuit with a transistor (74) and a resistor (76) for limiting the current through an optical isolator (68) for the AC/DC terminals (30).