Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: An apparatus and method for gravel packing an interval of a wellbore comprises an outer tubular (110), which forms a first annulus with the wellbore, and an inner tubular (114) disposed within the outer tubular (110) forming a second annulus therebetween. Within the second annulus is an axially extending production pathway (190) and an axially extending slurry passageway (194), which is defined between a channel (170) and the inner tubular (114). The outer tubular (110) has outlets (128) that are substantially aligned with outlets (178) of the channel (170). The portions of both the outer and inner tubulars (110, 114) adjacent the production pathway (190) have openings (122, 146). When a fluid slurry containing gravel is injected through the slurry passageway (194), the fluid slurry exits through the outlets (178, 128) leaving gravel in the first annulus, thereby gravel packing the interval.

Abstract: An apparatus and method for gravel packing an interval of a wellbore comprises an outer tubular (110), which forms a first annulus with the wellbore, and an inner tubular (114) disposed within the outer tubular (110) forming a second annulus therebetween. Within the second annulus is an axially extending production pathway (190) and an axially extending slurry passageway (194), which is defined between a channel (170) and the inner tubular (114). The outer tubular (110) has outlets (128) that are substantially aligned with outlets (178) of the channel (170). The portions of both the outer and inner tubulars (110, 114) adjacent the production pathway (190) have openings (122, 146). When a fluid slurry containing gravel is injected through the slurry passageway (194), the fluid slurry exits through the outlets (178, 128) leaving gravel in the first annulus, thereby gravel packing the interval.