Patents by Inventor Robert L. Fahrner

Robert L. Fahrner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyelectrolyte precipitation and purification of proteins
    Patent number: 7947813
    Abstract: Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: May 24, 2011
    Assignee: Genentech, Inc.
    Inventors: Robert L. Fahrner, Jayme Franklin, Paul McDonald, Thanmaya Peram, Vikram Sisodiya, Corazon Victa
  • Reducing protein A leaching during protein A affinity chromatography
    Patent number: 7807799
    Abstract: A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: October 5, 2010
    Assignee: Genentech, Inc.
    Inventors: Robert L. Fahrner, Amy Laverdiere, Paul J. McDonald, Rhona M. O'Leary
  • REDUCING PROTEIN A LEACHING DURING PROTEIN A AFFINITY CHROMATOGRAPHY
    Publication number: 20090099344
    Abstract: A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
    Type: Application
    Filed: November 12, 2008
    Publication date: April 16, 2009
    Inventors: Robert L. Fahrner, Amy Laverdiere, Paul J. McDonald, Rhona M. O'Leary
  • Reducing protein A leaching during protein A affinity chromatography
    Patent number: 7485704
    Abstract: A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: February 3, 2009
    Assignee: Genentech, Inc.
    Inventors: Robert L. Fahrner, Amy Laverdiere, Paul J. McDonald, Rhona M. O'Leary
  • POLYELECTROLYTE PRECIPITATION AND PURIFICATION OF PROTEINS
    Publication number: 20080193981
    Abstract: Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte.
    Type: Application
    Filed: January 10, 2008
    Publication date: August 14, 2008
    Inventors: Robert L. Fahrner, Jayme Franklin, Paul McDonald, Thanmaya Peram, Vikram Sisodiya, Corazon Victa
  • Protein purification
    Patent number: 6870034
    Abstract: A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: March 22, 2005
    Assignee: Genentech, Inc.
    Inventors: Timothy N. Breece, Robert L. Fahrner, Jeffrey R. Gorrell, Kathlyn Pham Lazzareschi, Philip M. Lester, David Peng
  • Protein purification
    Publication number: 20030153735
    Abstract: A method for purifying proteins by Protein A chromatography is described which comprises removing contaminants by washing the solid phase with various intermediate wash buffers.
    Type: Application
    Filed: February 3, 2003
    Publication date: August 14, 2003
    Applicant: GENENTECH, INC.
    Inventors: Timothy N. Breece, Robert L. Fahrner, Jeffrey R. Gorrell, Kathlyn Pham Lazzareschi, Philip M. Lester, David Peng